Results 41 to 50 of about 1,855,106 (245)

On how Happy Polish Advanced EFL Learners Are with Happy-Tensing [PDF]

, 2015
This paper aims at investigating the production of happY vowel by advanced Polish learners of English. Although happY tensing has become a regular feature of mainstream RP, it is not explicitly taught at English philologies in Poland.
Olender, Adam, Sypiańska, Jolanta
core   +1 more source

Inclusion, Contrast and Polysemy in Dictionaries: The Relationship between Theory, Language Use and Lexicographic Practice [PDF]

, 2014
This paper explores the lexicographic representation of a type of polysemy that arises when the meaning of one lexical item can either include or contrast with the meaning of another, as in the case of dog/bitch, shoe/boot, finger/thumb and animal/bird ...
Adrienne, Adrienne, Adrienne, Adrienne, Anu Koskela, Becker, Becker, Bloomsbury, Bloomsbury, Boston, Boston, Bybee, Bybee, Church, Church, Collins, Collins, Collins COBUILD, Collins COBUILD, Croft, Croft, Cruse, Cruse, Davies, Davies, Davies, Davies, Geeraerts, Geeraerts, Geeraerts, Geeraerts, Grice, Grice, Haspelmath, Haspelmath, Hearst, Hearst, Horn, Horn, Huang, Huang, Ide, Ide, Jones, Jones, Justeson, Justeson, Kempson, Kempson, Langacker, Langacker, Longman, Longman, Lyons, Lyons, Manning, Manning, Mettinger, Mettinger, Mititelu, Mititelu, Murphy, Murphy, Oxford, Oxford, Oxford, Oxford, Oxford, Oxford, Quine, Quine, Rohdenburg, Rohdenburg, Rohdenburg, Rohdenburg, Traugott, Traugott, Tuggy, Tuggy, Zgusta, Zgusta, Zwicky, Zwicky   +82 more
core   +2 more sources

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

The NF-κB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: The transcription factor NF-κB consisting of the subunits RelA/p65 and p50 is known to be quickly activated after partial hepatectomy (PH), the functional relevance of which is still a matter of debate.
Marc Ringelhan, Roland M Schmid, Fabian Geisler   +2 more
doaj   +1 more source

Discourse Markers and Modal Expressions in Speakers with and without Asperger Syndrome: A Pragmatic-Perceptive Approach [PDF]

, 2014
From a theoretical point of view, this paper offers a new framework for the analysis of discourse markers: a pragmatic-perceptive model that emphasizes the point of the communication process in which such particles become more relevant. Furthermore, this
Muñoz, Francisco J. Rodríguez
core   +1 more source

C11orf95-RELA Reprograms 3D Epigenome in Supratentorial Ependymoma [PDF]

Acta Neuropathologica, 2020
Supratentorial ependymoma (ST-EPN) is a type of malignant brain tumor mainly seen in children. Since 2014, it has been known that an intrachromosomal fusionC11orf95-RELAis an oncogenic driver in ST-EPN1but the molecular mechanisms of oncogenesis are unclear.
Jacqueline Jufen Zhu, Nathaniel Jillette, Xiao-Nan Li, Albert Wu Cheng, Ching C Lau   +4 more
openaire   +3 more sources

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Case report: Novel variants in RELA associated with familial Behcet’s-like disease

Frontiers in Immunology, 2023
RELA haploinsufficiency is a recently described autoinflammatory condition presenting with intermittent fevers and mucocutaneous ulcerations. The RELA gene encodes the p65 protein, one of five NF-κB family transcription factors.
Jason W. An, Jason W. An, Pallavi Pimpale-Chavan, Deborah L. Stone, Marcia Bandeira, Fatma Dedeoglu, Jeffrey Lo, John Bohnsack, Sofia Rosenzweig, Oskar Schnappauf, Dilan Dissanayake, Linda T. Hiraki, Daniel L. Kastner, Christina Pelajo, Ronald M. Laxer, Ronald M. Laxer, Ivona Aksentijevich   +16 more
doaj   +1 more source

Effect of Energy Metabolism on NF-kB activity in Ovarian Cancer [PDF]

, 2018
NF-kB is a transcription factor involved in cancer cell growth and survival. The activation of NF-kB can be assessed by monitoring phosphorylation of RelA p65 at Ser-536, which is a surrogate of the NF-kB transcription factor activation. The objective of
Bagri, Simren K
core   +1 more source

The Use of Lexical Cohesion Elements in the Writing of ESL Learners [PDF]

, 2016
This study investigated the use of lexical elements of cohesion in the essay writing of students of English as a Second Language. Two hundred essays of final year students of the University of Nigeria, Nsukka were collated and analyzed by the researchers
Beaugrande, Beaugrande, Cajetan Ikechukwu Egbe, Crystal, Crystal, December, December, Fatimah, Fatimah, Goodluck C. Kadiri, Gutwinski, Gutwinski, Halliday, Halliday, Halliday, Halliday, Hung, Hung, Kadiri, Kadiri, Murphy, Murphy, Otagburuagu, Otagburuagu, Uche Lebechi Igbokwe, Udodirim Ngozi Okebalama, Widdowson, Widdowson   +27 more
core   +1 more source