Results 31 to 40 of about 125,603 (234)

RelA/p65 Regulation of IκBβ [PDF]

Molecular and Cellular Biology, 2005
IκB inhibitor proteins are the primary regulators of NF-κB. In contrast to the defined regulatory interplay between NF-κB and IκBα, much less is known regarding the regulation of IκBβ by NF-κB. Here, we describe in detail the regulation of IκBβ by RelA/p65.
Erin Hertlein, Jingxin Wang, Katherine J. Ladner, Nadine Bakkar, Denis C. Guttridge   +4 more
openaire   +1 more source

A cascading policy learning framework for enhancing power grid resilience [PDF]

PeerJ Computer Science
Power grids, as critical cyber-physical systems, face increasing threats from adversarial attacks that can compromise their operational integrity. This article introduces a novel cascading policy learning framework that leverages a sequential application
Assem Sohaib Bensalah, Toufik Marir, Reda Yaich, Mohamed Sedik Chebout   +3 more
doaj   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Anterior chondral buttress plating for complex coronal shear fractures of the distal humerus. A retrospective case series

JSES International
Background: Internal fixation of complex coronal shear distal humerus fractures is challenged by the absence of metaphyseal osseous extension often limiting fixation strategies to intra-articular screws or wires alone.
Ashok S. Gavaskar, MS Orth, FRCS, Parthasarathy Srinivasan, DNB Orth, Prakash Ayyadurai, MS Orth, Bejoy P. George, MS Orth, Abraham M. Antony, MS Orth, K.N. Jotheesvar, MS Orth   +5 more
doaj   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Technical feasibility and short-term outcomes of single-incision endoscopic breast-conserving surgery with sentinel lymph node biopsy: initial Indian experience

BMC Surgery
Background Endoscopic breast-conserving surgery (EBCS) aims to offer improved cosmetic outcomes while maintaining oncologic safety. Although well established in East Asian programs¹⁻³, its use remains uncommon in India⁴.
Pon Jeeva Mathan, Keshavarajan Gandhirajan, Jagadesh Chandra Bose   +2 more
doaj   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

The NF-κB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: The transcription factor NF-κB consisting of the subunits RelA/p65 and p50 is known to be quickly activated after partial hepatectomy (PH), the functional relevance of which is still a matter of debate.
Marc Ringelhan, Roland M Schmid, Fabian Geisler   +2 more
doaj   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source