Results 31 to 40 of about 153,606 (275)
, 2022 Se desarrolla una alternativa mediante la cual los jóvenes puedan aprender sobre el café colombiano, dando a conocer las diferentes variables del producto y sus preparaciones, por medio de herramientas para explorar los sabores del café. ; An alternative is developed through which young people can learn about Colombian coffee, making known the ...
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RelA: a tale of a stitch in time [PDF]
Journal of Clinical Investigation, 2016 Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer in which NF-κB pathways promote biological aggressiveness. In this issue of the JCI, Lesina et al. investigated the role of RelA, the p65 partner of p50 that together form the most common NF-κB complex, in the early stages of pancreatic malignant transformation and in established PDAC.
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RelA Life and Death Decisions [PDF]
Molecular Cell, 2004 RelA is generally regarded as an activator of prosurvival gene transcription. However, in this issue of Molecular Cell, demonstrate that anticancer drugs turn RelA into an accomplice of apoptosis by instructing it to dominantly repress survival gene transcription.
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Dissection of the Mechanism for the Stringent Factor RelA [PDF]
Molecular Cell, 2002 During conditions of nutrient deprivation, ribosomes are blocked by uncharged tRNA at the A site. The stringent factor RelA binds to blocked ribosomes and catalyzes synthesis of (p)ppGpp, a secondary messenger that induces the stringent response. We demonstrate that binding of RelA and (p)ppGpp synthesis are inversely coupled, i.e., (p)ppGpp synthesis ...
Wendrich, T. +4 more
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SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]
, 2008 RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan +3 more
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EnABLing Cathepsin-Driven Melanoma Metastasis
Molecular & Cellular Oncology, 2018 Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases.
Rakshamani Tripathi, Rina Plattner
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A cascading policy learning framework for enhancing power grid resilience [PDF]
PeerJ Computer SciencePower grids, as critical cyber-physical systems, face increasing threats from adversarial attacks that can compromise their operational integrity. This article introduces a novel cascading policy learning framework that leverages a sequential application
Assem Sohaib Bensalah +3 more
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Characterization of RelA inAcinetobacter baumannii
Journal of Bacteriology, 2020 ABSTRACTIn response to nutrient depletion, the RelA and SpoT proteins generate the signaling molecule (p)ppGpp, which then controls a number of downstream effectors to modulate cell physiology. InAcinetobacter baumanniistrain AB5075, arelAortholog (ABUW_3302) was identified by a transposon insertion that conferred an unusual colony phenotype.
María, Pérez-Varela +4 more
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RelA/p65 Regulation of IκBβ [PDF]
Molecular and Cellular Biology, 2005 IκB inhibitor proteins are the primary regulators of NF-κB. In contrast to the defined regulatory interplay between NF-κB and IκBα, much less is known regarding the regulation of IκBβ by NF-κB. Here, we describe in detail the regulation of IκBβ by RelA/p65.
Erin Hertlein +4 more
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