Results 11 to 20 of about 125,603 (234)
Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA
RSC Chemical Biology, 2022 Discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to generate stable high molecular weight complexes. SpiD7 inhibits TNFα-induced nuclear translocation of RELA resulting in the blockade of NF-kB gene transcription, through a previously unexplored modality.
Smit Kour +8 more
openaire +3 more sources
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription [PDF]
Open Biology, 2016 The NF-κB signalling module controls transcription through a network of protein kinases such as the IKKs, as well as inhibitory proteins (IκBs) and transcription factors including RelA/p65.
Francesco Lanucara +10 more
doaj +1 more source
Acta Biomedica Scientifica, 2022 Signaling molecules such as indole (product of tryptophan catabolism) and (p)ppGpp (stringent response regulator) are involved in regulation of physiological processes in bacterial cells aimed to adapt to antibiotics and stresses.
N. M. Kashevarova +3 more
doaj +1 more source
Indian Journal of Radiology and Imaging, 2022 Mycotic pseudoaneurysm (MPA) is a blind, saccular outpouching of the arterial lumen of infective origin. MPA is a rare life-threatening condition and if not treated early, has a 67% mortality rate due to sepsis and hemorrhage.
Sinduja Sivaramalingam +5 more
doaj +1 more source
COVID-19: Poor outcomes in patients with zinc deficiency
International Journal of Infectious Diseases, 2020 Background: Zinc is a trace element with potent immunoregulatory and antiviral properties, and is utilized in the treatment of coronavirus disease 2019 (COVID-19).
Dinesh Jothimani +10 more
doaj +1 more source
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
Pharmaceutics, 2020 Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of cancer metastasis.
Hisako Ibaraki +5 more
doaj +1 more source
Biliary atresia: pathology, etiology and pathogenesis
Future Science OA, 2020 Biliary atresia is a progressive fibrosing obstructive cholangiopathy of the intrahepatic and extrahepatic biliary system, resulting in obstruction of bile flow and neonatal jaundice.
Mukul Vij, Mohamed Rela
doaj +1 more source
Transcription of ribosomal component genes and lac in a relA+/relA pair of Escherichia coli strains [PDF]
Journal of Bacteriology, 1984 To determine the stringent response, a repression of gene activity during amino acid starvation assumed to be mediated by the effector necleotide guanosine tetraphosphate (ppGpp), of metabolically regulated constitutive genes, we measured the transcription of ribosomal protein genes, the constitutive lac operon, and stable RNA genes in a variety of ...
R, Little, H, Bremer
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Influence of the relA gene on ribosome frameshifting [PDF]
Molecular Genetics and Genomics, 2002 We have examined the influence of genotype at the relA locus on the kinetics of leftward (or -1) frameshifting at a variety of codons calling for a limiting aminoacyl-tRNA species. We used lacZ left-frameshift reporter constructs carrying the sequenceU UUC XYZ, whereXYZ was each of three triplets coding for three different amino acids; we slowed the ...
Masucci, J. +3 more
openaire +2 more sources