Results 11 to 20 of about 153,606 (275)

ReLA v2.0

open access: yes, 2012
Durante el desarrollo de este proyecto final de carrera se aborda la creación e implementación del protocolo ReLA bajo un lenguaje de programación concreto y unificado en un único ejecutable.
González Rosado, Santiago
core   +3 more sources

Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA

open access: yesGenomics Data, 2016
The molecular mechanisms responsible for opposing oncogenic and tumor-suppressor activities of NF-kB are obscure. Semi-quantitative immunohistochemistry of primary breast tumors using antibodies to RelA, the pleiotropic NF-kB factor, and Ki67 revealed a ...
Bose S. Kochupurakkal, J. Dirk Iglehart
doaj   +2 more sources

Update on the Pathology of Pediatric Liver Tumors: A Pictorial Review

open access: yesDiagnostics, 2023
Liver tumors in children are uncommon and show remarkable morphologic heterogeneity. Pediatric tumors may arise from either the epithelial or mesenchymal component of the liver and rarely may also show both lines of differentiation.
Priyanka Bhagat   +8 more
doaj   +1 more source

A missense variant in NCF1 is associated with susceptibility to unexplained recurrent spontaneous abortion

open access: yesOpen Life Sciences, 2022
Unexplained recurrent spontaneous abortion (URSA) is a major concern in reproductive medicine. Neutrophil cytosolic factor 1 (NCF1) polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases.
Du Mengxuan   +9 more
doaj   +1 more source

Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA

open access: yesRSC Chemical Biology, 2022
Discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to generate stable high molecular weight complexes. SpiD7 inhibits TNFα-induced nuclear translocation of RELA resulting in the blockade of NF-kB gene transcription, through a previously unexplored modality.
Smit Kour   +8 more
openaire   +3 more sources

Role of alarmone (p)ppGpp in the regulation of indole formation depending on glucose content in Escherichia coli

open access: yesActa Biomedica Scientifica, 2022
Signaling molecules such as indole (product of tryptophan catabolism) and (p)ppGpp (stringent response regulator) are involved in regulation of physiological processes in bacterial cells aimed to adapt to antibiotics and stresses.
N. M. Kashevarova   +3 more
doaj   +1 more source

Salmonella Bacteremia Causing Mycotic Pseudoaneurysm of Right Common Iliac Artery Complicated by Septic Caval Thrombosis

open access: yesIndian Journal of Radiology and Imaging, 2022
Mycotic pseudoaneurysm (MPA) is a blind, saccular outpouching of the arterial lumen of infective origin. MPA is a rare life-threatening condition and if not treated early, has a 67% mortality rate due to sepsis and hemorrhage.
Sinduja Sivaramalingam   +5 more
doaj   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

open access: yesHepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie   +17 more
wiley   +1 more source

COVID-19: Poor outcomes in patients with zinc deficiency

open access: yesInternational Journal of Infectious Diseases, 2020
Background: Zinc is a trace element with potent immunoregulatory and antiviral properties, and is utilized in the treatment of coronavirus disease 2019 (COVID-19).
Dinesh Jothimani   +10 more
doaj   +1 more source

Purification and crystallization of RelA Mutants

open access: yes, 2017
The bacterial stringent response is the mechanism that bacteria have to respond to stress conditions such as limiting amino acids, limiting phosphate or fatty acids, carbon limitation or heat shock. When this happens, the stringent response is activated by the small alarmone (p)ppGpp.
Amagat Molas, Jordi
openaire   +2 more sources

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