Results 41 to 50 of about 153,606 (275)

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

RelA-DsRedxp E2F1-Venus BAC stables FCS molecular fluoresence Data

, 2016
Molecular fluorescence counts in single cells of RelA-DsRedxp E2F1-Venus BAC stables and correlation ...
Jones, Nicholas A., Harper, Claire V., Paszek, Pawel, James Boyd (3263352), Ankers, John M., White, Micheal R.H., Raheela Awais (3263343), Dean A. Jackson (191301), John M. Ankers (3263358), Claire V. Harper (224916), Bridge, Lloyd, Jackson, Dean A., Ryan, Sheila, Sée, Violaine, Lloyd Bridge (3263361), David G. Spiller (135239), Anotony D. Adamson (3263364), Micheal R.H. White (3263385), Nicholas A. Jones (3263346), Pawel Paszek (39848), Adamson, Anotony D., Awais, Raheela, Boyd, James, Spiller, David G., Violaine Sée (3263349), Sheila Ryan (1794853)   +25 more
core   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

RelA-DsRedxp E2F1-Venus BAC stables Representitive cell traces

, 2016
RelA-DsRedexpress and E2F1-Venus BAC stables Representative cell traces separated into cell cycle phases by virtual ...
Jones, Nicholas A., Harper, Claire V., Paszek, Pawel, James Boyd (3263352), Ankers, John M., White, Micheal R.H., Raheela Awais (3263343), Dean A. Jackson (191301), John M. Ankers (3263358), Claire V. Harper (224916), Bridge, Lloyd, Jackson, Dean A., Ryan, Sheila, Sée, Violaine, Lloyd Bridge (3263361), David G. Spiller (135239), Anotony D. Adamson (3263364), Micheal R.H. White (3263385), Nicholas A. Jones (3263346), Pawel Paszek (39848), Adamson, Anotony D., Awais, Raheela, Boyd, James, Spiller, David G., Violaine Sée (3263349), Sheila Ryan (1794853)   +25 more
core   +1 more source

The NF-κB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: The transcription factor NF-κB consisting of the subunits RelA/p65 and p50 is known to be quickly activated after partial hepatectomy (PH), the functional relevance of which is still a matter of debate.
Marc Ringelhan, Roland M Schmid, Fabian Geisler   +2 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

MOESM9 of TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development

, 2019
Additional file 9: Figure S5. The interaction between RelA and BS-2 probe is identified by EMSA.
Hongbin Fan (7440380), Xuebin Qu (7440377), Fang Hua (261296), Xingqi Wang (5064455), Ruiqin Yao (7440383), Jingjing Han (3071379), Ying Zhang (40767)   +6 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

MOESM8 of TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development

, 2019
Additional file 8: Figure S4. Gel electropherogram of ChIP-PCR products at three predicted RelA binding sites (BS-1, BS-2 and BS-3).
Hongbin Fan (7440380), Xuebin Qu (7440377), Fang Hua (261296), Xingqi Wang (5064455), Ruiqin Yao (7440383), Jingjing Han (3071379), Ying Zhang (40767)   +6 more
core   +1 more source