Results 61 to 70 of about 153,606 (275)
Antimicrobial Agents and Chemotherapy, 2017 ABSTRACT The nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance, and virulence. During amino acid starvation, the Escherichia coli (p)ppGpp synthetase RelA is activated by deacylated tRNA in the ribosomal A-site.
Kudrin, Pavel +9 more
openaire +3 more sources
Characterization of aLegionella pneumophila relAInsertion Mutant and Roles of RelA and RpoS in Virulence Gene Expression [PDF]
Journal of Bacteriology, 2002 ABSTRACTTo investigate the involvement of RelA in the regulation ofLegionella pneumophilavirulence, a deletion substitution was constructed in therelAgene. TherelAknockout resulted in an undetectable level of ppGpp in the cells during the stationary phase, but the original level was restored when therelAgene product was supplied on a plasmid.
Tal, Zusman, Ohad, Gal-Mor, Gil, Segal
openaire +2 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg +9 more
wiley +1 more source
Computers, 2020 Video streaming is one of the challenging issues in vehicular ad-hoc networks (VANETs) due to their highly dynamic topology and frequent connectivity disruptions.
Abdelkader Benmir +4 more
doaj +1 more source
Talking to histone: methylated RelA serves as a messenger [PDF]
Cell Research, 2011 The mammalian NF-κB family of transcription factors functions as a major regulator of innate and adaptive immunity and inflammatory responses, plays critical roles in controlling cell proliferation, differentiation and apoptosis by regulating a wide range of genes that govern these various processes 1.
Xiao-Dong, Yang, Lin-Feng, Chen
openaire +2 more sources
BMEMat, EarlyView.TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing +6 more
wiley +1 more source
Assessment of airway distribution of transnasal solutions in mice by PET/CT imaging. [PDF]
, 2009 PURPOSE: Transnasal administration is one of the most common routes for allergen challenge in mouse models of airway diseases. Although this technique is widely used, neither the amount of allergen that reaches the lung nor its airway distribution has ...
Zubeldia, José Manuel +27 more
core +1 more source
p47 Participates in Activation of RelA in Endothelial Cells [PDF]
Journal of Biological Chemistry, 2003 Activation of endothelial cell NF-kappaB by interleukin (IL)-1 constitutes an event critical to the progression of the innate immune response. In this context, oxidants have been associated with NF-kappaB activation, although the molecular source and mechanism of targeting have remained obscure. We found that RelA, essential for NF-kappaB activation by
Ying, Gu +6 more
openaire +2 more sources
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT Green bonds play a central role in sustainable finance, yet concerns about greenwashing raise questions about the credibility of issuers' sustainability disclosures. Using dictionary‐based methods and domain‐specific BERT transformer models, this paper proposes two greenwashing alert metrics and investigates their performance by analyzing ...
Andrea Nicolodi +4 more
wiley +1 more source
, 2013 The homodimerization of RelA has been analysed by bimolecular fluorescence complementation in living plant protoplasts. The EYFP emission was recorded in 40 cells and normalized to ECFP-emission. Mean average ± S.E. is shown.
Markus Sauer (16847) +9 more
core +1 more source