Results 51 to 60 of about 153,606 (275)

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

MOESM5 of TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development

, 2019
Additional file 5: Figure S1. Pattern diagram showing the sequences and locations of primers for ChIP-PCR. The sequences in yellow show the predicted RelA binding sites (BS-1, BS-2 and BS-3)
Hongbin Fan (7440380), Xuebin Qu (7440377), Fang Hua (261296), Xingqi Wang (5064455), Ruiqin Yao (7440383), Jingjing Han (3071379), Ying Zhang (40767)   +6 more
core   +1 more source

The 1α,25(OH)2D3 Analogs ZK159222 and ZK191784 Show Anti-Inflammatory Properties in Macrophage-Induced Preadipocytes via Modulating the NF-κB and MAPK Signaling

Diabetes, Metabolic Syndrome and Obesity, 2020
Jingjing Zhu,1,2 John PH Wilding2,3 1Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Institute of Ageing and Chronic Disease, University of Liverpool ...
Zhu J, Wilding JPH
doaj  

NF-κB repression by PIAS3 mediated RelA SUMOylation. [PDF]

PLoS ONE, 2012
Negative regulation of the NF-κB transcription factor is essential for tissue homeostasis in response to stress and inflammation. NF-κB activity is regulated by a variety of biochemical mechanisms including phosphorylation, acetylation, and ...
Yuangang Liu, Rebecca Bridges, Aaron Wortham, Molly Kulesz-Martin   +3 more
doaj   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

Overexpression of the relA gene in Escherichia coli

Journal of Biological Chemistry, 1991
Intracellular levels of guanosine 3',5'-bispyrophosphate (ppGpp) governed by the relA gene are normally regulated by aminoacyl-tRNA availability for protein synthesis. An experimental system is described in which cellular levels of ppGpp are controlled instead by induction of plasmid pKK223-3 derivatives with the relA structural gene, or portions ...
G, Schreiber, S, Metzger, E, Aizenman, S, Roza, M, Cashel, G, Glaser   +5 more
openaire   +2 more sources

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

RelA-DsRedxp E2F1-Venus BAC stables FCS Autocorrolation and cross-corrolation data

, 2016
RelA-DsRedxp E2F1-Venus BAC stables FCS autocorrolation and cross-corrolation ...
Jones, Nicholas A., Harper, Claire V., Paszek, Pawel, James Boyd (3263352), Ankers, John M., White, Micheal R.H., Raheela Awais (3263343), Dean A. Jackson (191301), John M. Ankers (3263358), Claire V. Harper (224916), Bridge, Lloyd, Jackson, Dean A., Ryan, Sheila, Sée, Violaine, Lloyd Bridge (3263361), David G. Spiller (135239), Anotony D. Adamson (3263364), Micheal R.H. White (3263385), Nicholas A. Jones (3263346), Pawel Paszek (39848), Adamson, Anotony D., Awais, Raheela, Boyd, James, Spiller, David G., Violaine Sée (3263349), Sheila Ryan (1794853)   +25 more
core   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source