Results 51 to 60 of about 125,603 (234)

Characterization of aLegionella pneumophila relAInsertion Mutant and Roles of RelA and RpoS in Virulence Gene Expression [PDF]

Journal of Bacteriology, 2002
ABSTRACTTo investigate the involvement of RelA in the regulation ofLegionella pneumophilavirulence, a deletion substitution was constructed in therelAgene. TherelAknockout resulted in an undetectable level of ppGpp in the cells during the stationary phase, but the original level was restored when therelAgene product was supplied on a plasmid.
Tal, Zusman, Ohad, Gal-Mor, Gil, Segal
openaire   +2 more sources

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Talking to histone: methylated RelA serves as a messenger [PDF]

Cell Research, 2011
The mammalian NF-κB family of transcription factors functions as a major regulator of innate and adaptive immunity and inflammatory responses, plays critical roles in controlling cell proliferation, differentiation and apoptosis by regulating a wide range of genes that govern these various processes 1.
Xiao-Dong, Yang, Lin-Feng, Chen
openaire   +2 more sources

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

p47 Participates in Activation of RelA in Endothelial Cells [PDF]

Journal of Biological Chemistry, 2003
Activation of endothelial cell NF-kappaB by interleukin (IL)-1 constitutes an event critical to the progression of the innate immune response. In this context, oxidants have been associated with NF-kappaB activation, although the molecular source and mechanism of targeting have remained obscure. We found that RelA, essential for NF-kappaB activation by
Ying, Gu, You Cheng, Xu, Ru Feng, Wu, Fiemu E, Nwariaku, Rhonda F, Souza, Sonia C, Flores, Lance S, Terada   +6 more
openaire   +2 more sources

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

GeoQoE-Vanet: QoE-Aware Geographic Routing Protocol for Video Streaming over Vehicular Ad-hoc Networks

Computers, 2020
Video streaming is one of the challenging issues in vehicular ad-hoc networks (VANETs) due to their highly dynamic topology and frequent connectivity disruptions.
Abdelkader Benmir, Ahmed Korichi, Abdelhabib Bourouis, Mohammed Alreshoodi, Laith Al-Jobouri   +4 more
doaj   +1 more source

RelA Inhibits Bacillus subtilis Motility and Chaining [PDF]

Journal of Bacteriology, 2015
ABSTRACT The nucleotide second messengers pppGpp and ppGpp [(p)ppGpp] are responsible for the global downregulation of transcription, translation, DNA replication, and growth rate that occurs during the stringent response. More recent studies suggest that (p)ppGpp is also an important effector in many nonstringent processes ...
Qutaiba O, Ababneh, Jennifer K, Herman
openaire   +2 more sources

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

Age‐Associated B Cells Contribute to Inflammation Via Antibody‐Independent Mechanisms in Takayasu Arteritis

Arthritis &Rheumatology, EarlyView.
Objective Although Takayasu arteritis (TAK) is not a prototypical autoantibody‐mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B cell activation and its contributions to TAK pathogenesis. Methods Histologic analysis of paravascular lymph nodes and affected arteries was conducted
Chenglong Fang, Xiaoxi Yang, Xiaochuan Sun, Shangyi Jin, Lihong Du, Jinwei Gao, Jing Li, Zhen Chen, Yuexin Chen, Mengtao Li, Xinping Tian   +10 more
wiley   +1 more source