Results 61 to 70 of about 1,855,106 (245)

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

A real-space, rela-time method for the dielectric function

, 2000
We present an algorithm to calculate the linear response of periodic systems in the time-dependent density functional thoery, using a real-space representation of the electron wave functions and calculating the dynamics in real time.
Angel Rubio, F. Kootstra, G. F. Bertsch, G. Ortiz, H. Bross, H. Flocard, I. Vasiliev, J. Chelikowsky, J. Perdew, J.-I. Iwata, J.F. Dobson, K. Yabana, K. Yabana, K. Yabana, L. Kleinman, M.S. Hybertsen, N. Troullier, R. Resta, R. Resta, R.W. Godby, V.I. Gavrilenko, X. Gonze   +21 more
core   +1 more source

Measuring Syntactic Complexity in Spoken and Written Learner Language: Comparing the Incomparable? [PDF]

, 2014
Spoken and written language are two modes of language. When learners aim at higher skill levels, the expected outcome of successful second language learning is usually to become a fluent speaker and writer who can produce accurate and complex language in
Bardovi, Bardovi, Baron, Baron, Beaman, Beaman, Bergman, Bergman, Bourdin, Bourdin, Brown, Brown, Bulté, Bulté, Cambridge, Cambridge, Cleland, Cleland, Conrad, Conrad, Ellis, Ellis, Ellis, Ellis, Foster, Foster, Gaies, Gaies, Gilabert, Gilabert, Halleck, Halleck, Halliday, Halliday, Halliday, Halliday, Housen, Housen, Housen, Housen, Housen, Housen, Hunt, Hunt, Ishikawa, Ishikawa, Ishikawa, Ishikawa, Iwashita, Iwashita, Kuiken, Kuiken, Larsen, Larsen, Larsen, Larsen, Larson, Larson, Leech, Leech, Mari Mäkilä, Norris, Norris, Norwood, Norwood, Ortega, Ortega, Ortega, Ortega, Pallotti, Pallotti, Pekka Lintunen, Pica, Pica, Pietilä, Pietilä, Robinson, Robinson, Robinson, Robinson, Scarborough, Scarborough, Sharma, Sharma, Silva, Silva, Silva, Silva, Skehan, Skehan, Skehan, Skehan, Storch, Storch, Szmrecsányi, Szmrecsányi, Tanskanen, Tanskanen, Tavakoli, Tavakoli, Tonkyn, Tonkyn, Towell, Towell, Vyatkina, Vyatkina, Wolfe, Wolfe, Zhang, Zhang   +109 more
core   +1 more source

RelA Inhibits Bacillus subtilis Motility and Chaining [PDF]

Journal of Bacteriology, 2015
ABSTRACT The nucleotide second messengers pppGpp and ppGpp [(p)ppGpp] are responsible for the global downregulation of transcription, translation, DNA replication, and growth rate that occurs during the stringent response. More recent studies suggest that (p)ppGpp is also an important effector in many nonstringent processes ...
Qutaiba O, Ababneh, Jennifer K, Herman
openaire   +2 more sources

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

The 1α,25(OH)2D3 Analogs ZK159222 and ZK191784 Show Anti-Inflammatory Properties in Macrophage-Induced Preadipocytes via Modulating the NF-κB and MAPK Signaling

Diabetes, Metabolic Syndrome and Obesity, 2020
Jingjing Zhu,1,2 John PH Wilding2,3 1Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Institute of Ageing and Chronic Disease, University of Liverpool ...
Zhu J, Wilding JPH
doaj  

Vat. copt. 57: A Codicological, Literary, and Paratextual Analysis [PDF]

, 2018
MS Vatican City, Biblioteca Apostolica Vaticana Vat. copt. 57, a collection of homi- lies attributed to John Chrysostom in Bohairic Coptic, poses a number of challenges to scholars.
Berno, Francesco, Buzi, Paola, Soldati, AGOSTINO GIORGIO FRANCESCO, Valerio, Francesco   +3 more
core   +1 more source

Characterization of RelA inAcinetobacter baumannii

Journal of Bacteriology, 2020
ABSTRACTIn response to nutrient depletion, the RelA and SpoT proteins generate the signaling molecule (p)ppGpp, which then controls a number of downstream effectors to modulate cell physiology. InAcinetobacter baumanniistrain AB5075, arelAortholog (ABUW_3302) was identified by a transposon insertion that conferred an unusual colony phenotype.
María, Pérez-Varela, Aimee R P, Tierney, Ju-Sim, Kim, Andrés, Vázquez-Torres, Philip, Rather   +4 more
openaire   +3 more sources

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Fluctuations in Learners’ Willingness to Communicate During Communicative Task Performance: Conditions and Tendencies [PDF]

, 2014
A person’s willingness to communicate (WTC), believed to stem from a combination of proximal and distal variables comprising psychological, linguistic, educational and communicative dimensions of language, appears to be a significant predictor of success
Anna Mystkowska-Wiertelak, Asker, Asker, Baker, Baker, Burgoon, Burgoon, Cao, Cao, Chan, Chan, Clément, Clément, Clément, Clément, Clément, Clément, Dörnyei, Dörnyei, Dörnyei, Dörnyei, Gardner, Gardner, Gass, Gass, Gottingen, Gottingen, Gregersen, Gregersen, Hashimoto, Hashimoto, Horwitz, Horwitz, Kang, Kang, Kuhl, Kuhl, Kuhl, Kuhl, Lantolf, Lantolf, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, MacIntyre, McCroskey, McCroskey, McCroskey, McCroskey, McCroskey, McCroskey, Mirosław Pawlak, Munezane, Munezane, Newbury Park, Newbury Park, Noels, Noels, Noels, Noels, Pawlak, Pawlak, Peng, Peng, Peng, Peng, Peng, Peng, Peng, Peng, Ritchie, Ritchie, Ryan, Ryan, Swain, Swain, Swain, Swain, Ushioda, Ushioda, Vygotsky, Vygotsky, Williams, Williams, Yashima, Yashima, Yashima, Yashima, Yashima, Yashima   +105 more
core   +1 more source