Results 71 to 80 of about 1,855,106 (245)

Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA -Dependent and relA -Independent Tolerance to β-Lactams

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACT The nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance, and virulence. During amino acid starvation, the Escherichia coli (p)ppGpp synthetase RelA is activated by deacylated tRNA in the ribosomal A-site.
Kudrin, Pavel, Varik, Vallo, Oliveira, Sofia Raquel Alves, Beljantseva, Jelena, Del Peso Santos, Teresa, Dzhygyr, Ievgen, Rejman, Dominik, Cava, Felipe, Tenson, Tanel, Hauryliuk, Vasili   +9 more
openaire   +3 more sources

Myeloid RelA regulates pulmonary host defense networks [PDF]

European Respiratory Journal, 2009
The pulmonary innate immune system in the respiratory tract eliminates inhaled pathogens. Several cell types contribute to host defense within a complex network. The aim of this study was to evaluate the role of macrophages during pneumonia and in the regulation of the epithelial response to microorganisms.We performed lung infection models in mice ...
C, Hess, C, Herr, C, Beisswenger, T, Zakharkina, R M, Schmid, R, Bals   +5 more
openaire   +2 more sources

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, EarlyView.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

GeoQoE-Vanet: QoE-Aware Geographic Routing Protocol for Video Streaming over Vehicular Ad-hoc Networks

Computers, 2020
Video streaming is one of the challenging issues in vehicular ad-hoc networks (VANETs) due to their highly dynamic topology and frequent connectivity disruptions.
Abdelkader Benmir, Ahmed Korichi, Abdelhabib Bourouis, Mohammed Alreshoodi, Laith Al-Jobouri   +4 more
doaj   +1 more source

The Impact of Rhythmic Distortions in Speech on Personality Assessment [PDF]

, 2014
The perennial question as to how perceived otherness in speech projects into listener assessment of one’s personality has been systematically investigated within the field of foreign accentedness, vocal communication of affective states and vocal ...
Boersma, Boersma, Gluszek, Gluszek, Gluszek, Gluszek, Jan Volín, Jenkins, Jenkins, Kehrein, Kehrein, Keysar, Keysar, Kristýna Poesová, McCrae, McCrae, Mohammadi, Mohammadi, Munro, Munro, Radek Skarnitzl, Scherer, Scherer, Teshigawara, Teshigawara, Trouvain, Trouvain, Volín, Volín, Volín, Volín, Volín, Volín, Volínová, Volínová, Walker, Walker, Zuckerman, Zuckerman   +38 more
core   +1 more source

Intratumoral Fusobacterium nucleatum Drives Cancer‐Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Fusobacterium nucleatum contributes to the progression of ESCC by inducing NF‐κB–mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, F.
Takashi Ofuchi, Qingjiang Hu, Kazuki Omachi, Kosuke Kanemitsu, Hajime Otsu, Yusuke Yonemura, Taro Tobo, Yoshifumi Baba, Masaaki Iwatsuki, Koshi Mimori   +9 more
wiley   +1 more source

Replication of plasmids derived from Shiga toxinconverting bacteriophages in starved Escherichia coli [PDF]

, 2011
The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that replication of the
Nadratowska-Wesołowska, Beata, Nejman, Bożena, Szalewska-Pałasz, Agnieszka, Węgrzyn, Alicja, Węgrzyn, Grzegorz   +4 more
core  

Stop Release in Polish English — Implications for Prosodic Constituency [PDF]

, 2014
Although there is little consensus on the relevance of non-contrastive allophonic processes in L2 speech acquisition, EFL pronunciation textbooks cover the suppression of stop release in coda position.
Anna Balas, Arkadiusz Rojczyk, Arsenault, Arsenault, Bergier, Bergier, Best, Best, Best, Best, Boersma, Boersma, Bogacka, Bogacka, Cook, Cook, Cruttenden, Cruttenden, Dukiewicz, Dukiewicz, Flege, Flege, Geoffrey Schwartz, Jenkins, Jenkins, Kahn, Kahn, Kang, Kang, Kang, Kang, Lindblom, Lindblom, Rojczyk, Rojczyk, Schwartz, Schwartz, Steriade, Steriade, Wright, Wright   +40 more
core   +2 more sources

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

The Interaction of Yer Deletion and Nasal Assimilation in Optimality Theory1 [PDF]

, 2015
The problem of opacity presents a challenge for generative phonology. This paper examines the process of Nasal Assimilation in Polish rendered opaque by the process of Vowel Deletion in Optimality Theory (Prince & Smolensky, 1993), which currently is a ...
Iwan, Karolina
core   +1 more source