Results 91 to 100 of about 9,939 (212)

Monte-Carlo Simulation of Heavy Ion Track Structure Calculation of Local Dose and 3D Time Evolution of Radiolytic Species [PDF]

, 2010
Heavy ions have gained considerable importance in radiotherapy due to their advantageous dose distribution profile and high Relative Biological Effectiveness (RBE).
Cucinotta, Francis A., Plante, Ianik
core   +1 more source

Targeting DNA-dependent protein kinase sensitizes hepatocellular carcinoma cells to proton beam irradiation through apoptosis induction.

PLoS ONE, 2019
Recent studies have highlighted the implications of genetic variations in the relative biological effectiveness (RBE) of proton beam irradiation over conventional X-ray irradiation.
Changhoon Choi, Arang Son, Ga-Haeng Lee, Sung-Won Shin, Sohee Park, Sang Hee Ahn, Yoonsun Chung, Jeong Il Yu, Hee Chul Park   +8 more
doaj   +1 more source

MCHIT - Monte Carlo model for proton and heavy-ion therapy

, 2007
We study the propagation of nucleons and nuclei in tissue-like media within a Monte Carlo Model for Heavy-ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.2).
Greiner, Walter, Mishustin, Igor, Pshenichnov, Igor   +2 more
core   +1 more source

Predicting Cell Death and Mutation Frequency for a Wide Spectrum of LET by Assuming DNA Break Clustering Inside Repair Domains [PDF]

Cosmic radiation, which is composed of high charged and energy (HZE) particles, is responsible for cell death and mutation, which may be involved in cancer induction. Mutations are consequences of mis-repaired DNA breaks especially double-strand breaks (
Blattnig, Steve R., Costes, Sylvain V., Evain, Trevor, Pariset, Eloise, Plante, Ianik, Ponomarev, Artem L., Viger, Louise   +6 more
core   +1 more source

ABSTRACTS

Precision Radiation Oncology, EarlyView.
wiley   +1 more source

Variable Relative Biological Effectiveness of Protons in the Rat Spinal Cord: Measurements and Comparison With Model Calculations

Advances in Radiation Oncology
Purpose: To determine the relative biological effectiveness (RBE) in the rat spinal cord after 6 fractions of protons as a function of linear energy transfer (LET) and dose.
Christin Glowa, PhD, Maria Saager, PhD, Lisa Hintz, MSc, Rosemarie Euler-Lange, BSc, Peter Peschke, PhD, Stephan Brons, PhD, Kaya Hilt, MSc, Thomas Friedrich, PhD, Michael Scholz, PhD, Hans Liew, PhD, Andrea Mairani, PhD, Christian P. Karger, PhD   +11 more
doaj   +1 more source

Evaluation of relative biological effectiveness of 225Ac and its decay daughters with Monte Carlo track structure simulations

EJNMMI Physics
Background 225Ac is a radionuclide that can be utilized in targeted alpha therapy (TAT). To accurately assess the absorbed dose and radiation effects in TAT, it is necessary to calculate the relative biological effectiveness (RBE).
Ziyi Hu, Shuiyin Qu, Hongming Liu, Yunhao Zhang, Shuchang Yan, Ankang Hu, Rui Qiu, Zhen Wu, Hui Zhang, Junli Li   +9 more
doaj   +1 more source

Deviations from the inverse relationship between tumor and normal tissue dose and RBE in fast neutron data are compatible with the presence of hypoxia, with possible applications to hypo-fractionated proton therapy

Frontiers in Oncology
Aim of studyFast neutron data from Hammersmith (UK) showed that the inverse relationship between dose and RBE (Relative Biological Effectiveness) is not maintained in many in vivo situations, originally attributed to hypoxic effects.
Bleddyn Jones, Bleddyn Jones
doaj   +1 more source

Reproducing the NIRS-QST Clinical Dose Calculations for Carbon Ion Radiotherapy Using Microdosimetric Probability Density Distributions

Radiation
Ion radiotherapy requires accurate relative biological effectiveness (RBE) calculations to account for the markedly different biological effects of ions compared to photons.
Alessio Parisi, Keith M. Furutani, Shannon Hartzell, Chris J. Beltran   +3 more
doaj   +1 more source

Cataract production in mice by heavy charged particles [PDF]

The cataractogenic effects of heavy charged particles are evaluated in mice in relation to dose and ionization density. The relative biological effectiveness in relation to linear energy transfer for various particles is considered.
Ainsworth, E. J., Barker, M. E., Jose, U., Yang, V. V.   +3 more
core   +1 more source