Results 1 to 10 of about 21,165 (234)
Neurobiology of Disease, 2018 Remyelination is an endogenous regenerative process of myelin repair in the central nervous system (CNS) with limited efficacy in demyelinating disorders.
Gemma Llufriu-Dabén +12 more
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EEF1A1 deacetylation enables transcriptional activation of remyelination
Nature Communications, 2020 The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and ...
Mert Duman +14 more
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Effect of glial cells on remyelination after spinal cord injury
Neural Regeneration Research, 2017 Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated,
Hai-feng Wang +12 more
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Nature Communications, 2020 Impaired oligodendrocyte (OL) differentiation and remyelination after myelin damage in multiple sclerosis is associated with neurodegeneration. The authors show that Gsta4 is expressed during adult OL differentiation and identify it as a regulator of OL ...
Karl E. Carlström +8 more
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Regulatory B Cells Normalize CNS Myeloid Cell Content in a Mouse Model of Multiple Sclerosis and Promote Oligodendrogenesis and Remyelination [PDF]
, 2020 Andrea Pennati +3 more
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CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents
Nature CommunicationsIn Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore fast saltatory conduction and neuroprotection but is inefficient in MS especially ...
Laura J. Wagstaff +6 more
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Systemic TLR2 tolerance enhances central nervous system remyelination
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko +9 more
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In vivo analysis of demyelination and remyelination in an animal model of multiple sclerosis [PDF]
, 2020 Aleksandra Mężydło
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Dynamic response of microglia/macrophage polarization following demyelination in mice
Journal of Neuroinflammation, 2019 Background The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function.
Tianci Chu +9 more
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Microglia contributes to remyelination in cerebral but not spinal cord ischemia [PDF]
, 2021 Goran Pavic +12 more
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