Results 1 to 10 of about 95 (92)
Regenerative Capacity of Macrophages for Remyelination [PDF]
Frontiers in Cell and Developmental Biology, 2016 White matter injury, consisting of loss of axons, myelin, and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is restored to axons, thereby facilitating recovery from functional loss.
Manoj K Mishra, V Wee Yong, John M Starr
exaly +5 more sources
Remyelination Therapy in Multiple Sclerosis [PDF]
Frontiers in Neurology, 2015 Multiple sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration. Current treatments approved for the treatment of relapsing forms of MS target the aberrant immune response and successfully reduce the severity of attacks and ...
Danielle E Harlow +2 more
exaly +4 more sources
The Role of Astrocytes in Remyelination [PDF]
Trends in Neurosciences, 2020 Remyelination is the regeneration of myelin sheaths following demyelination. This regenerative process is critical for the re-establishment of axonal conduction velocity and metabolic support to the axons. Successful remyelination in the CNS generally depends on the activation, proliferation, and differentiation of oligodendrocyte progenitor cells ...
Rawji, Khalil S +3 more
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Promoting remyelination in multiple sclerosis [PDF]
Journal of Neurology, 2019 AbstractThe greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduction and prevents neurodegeneration.
Cunniffe, Nick, Coles, Alasdair
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Astrocytes in myelination and remyelination
Neuroscience Letters, 2019 Astrocytes are known to play critical roles in central nervous system development, homeostasis, and response to injury. In addition to well-defined functions in synaptic signalling and blood-brain barrier control, astrocytes are now emerging as important contributors to white matter health.
Irene Molina-Gonzalez +1 more
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Experimental models of demyelination and remyelination
Neurología (English Edition), 2020 Experimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary.We reviewed the
Lidia Moreno-Jiménez +5 more
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Hedgehog Signaling in CNS Remyelination
Cells, 2022 Remyelination is a fundamental repair process in the central nervous system (CNS) that is triggered by demyelinating events. In demyelinating diseases, oligodendrocytes (OLs) are targeted, leading to myelin loss, axonal damage, and severe functional impairment.
Minxi Fang +3 more
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Remyelination in multiple sclerosis
Journal of the Neurological Sciences, 2003 Remyelination in multiple sclerosis (MS) lesions has been described in several studies. It depends on the presence of myelinating oligodendrocytes and a functional interaction between these myelinating cells and axons. The imaging signal of remyelination in magnetic resonance imaging or spectroscopy is not yet defined.
Brück, Wolfgang +2 more
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Glia Disease and Repair—Remyelination [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, although this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granular neurons, the same is not true of its glial elements.
Franklin, Robin J M, Goldman, Steven A
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Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source