Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis
Frontiers in Molecular Neuroscience, 2022 Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). In people with MS, impaired remyelination and axonal loss lead to debilitating long-term neurologic deficits.
Marjan Gharagozloo +3 more
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Cell Reports, 2021 Summary: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability.
Kimberle Shen +9 more
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A New Model of Cuprizone-Mediated Demyelination/Remyelination [PDF]
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs +4 more
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Remyelination Therapy in Multiple Sclerosis
Frontiers in Neurology, 2015 Multiple Sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration.
Danielle E Harlow +2 more
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Regenerative Capacity of Macrophages for Remyelination
Frontiers in Cell and Developmental Biology, 2016 White matter injury, consisting of loss of axons, myelin and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is
Manoj K Mishra, V Wee Yong, John M Starr
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Dicer deficiency affects microglial function during demyelination and impairs remyelination [PDF]
Neurobiology of DiseaseMicroglia are essential regulators of central nervous system (CNS) homeostasis, playing key roles in demyelination and remyelination. Dysregulated microglial activity contributes to pathological inflammation and impaired repair processes in demyelinating
Ajai Tripathi +7 more
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Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function [PDF]
Nature CommunicationsMyelin loss induces neural dysfunction and contributes to the pathophysiology of neurodegenerative diseases, injury conditions, and aging. Because remyelination is often incomplete, better understanding endogenous remyelination and developing ...
Gustavo Della-Flora Nunes +19 more
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Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells
Frontiers in Molecular Neuroscience, 2019 In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that surrounds axons, a process known as demyelination. The spontaneous regeneration of myelin, called remyelination, is associated with restoration of function and ...
Charbel S Baaklini +2 more
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Senescent-like microglia limit remyelination through the senescence associated secretory phenotype [PDF]
Nature CommunicationsThe capacity to regenerate myelin in the central nervous system diminishes with age. This decline is particularly evident in multiple sclerosis (MS), a chronic demyelinating disease.
Phillip S. Gross +14 more
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Remyelination can be extensive in multiple sclerosis despite a long disease course [PDF]
Neuropathology and Applied Neurobiology, 2007 Arman Kilic
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