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Age-impaired remyelination is associated with dysregulated microglial transitions [PDF]
Nature CommunicationsMultiple sclerosis (MS) is a chronic, inflammatory condition characterized by neurodegeneration and lost myelin, or demyelination. This lost myelin may be regenerated in people with MS through a process called remyelination, that is prone to failure and ...
Sameera Zia +36 more
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Remyelination Therapy in Multiple Sclerosis [PDF]
Frontiers in Neurology, 2015 Multiple Sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration.
Danielle E. Harlow +2 more
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Hedgehog Signaling in CNS Remyelination
Cells, 2022 Remyelination is a fundamental repair process in the central nervous system (CNS) that is triggered by demyelinating events. In demyelinating diseases, oligodendrocytes (OLs) are targeted, leading to myelin loss, axonal damage, and severe functional ...
Minxi Fang +3 more
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Neurology Neuroimmunology & Neuroinflammation, 2021 Neuroaxonal loss is believed to underpin the progressive disability that characterizes multiple sclerosis (MS). While focal inflammatory demyelination is a principal cause of acute axonal transection and subsequent axonal degeneration, the gradual attrition of permanently demyelinated axons may also contribute to tissue damage, particularly in the ...
Klistorner, Alexandr, Barnett, Michael
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Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration
Frontiers in Molecular Neuroscience, 2023 Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains over the past decade with many regeneration strategies undergoing tested in
Davin Packer +2 more
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Microglia promote remyelination independent of their role in clearing myelin debris
Cell Reports, 2023 Summary: Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination.
Charbel S. Baaklini +17 more
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In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis
eLife, 2023 Remyelination is crucial to recover from inflammatory demyelination in multiple sclerosis (MS). Investigating remyelination in vivo using magnetic resonance imaging (MRI) is difficult in MS, where collecting serial short-interval scans is challenging ...
Maxime Donadieu +14 more
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Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis
Frontiers in Molecular Neuroscience, 2022 Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). In people with MS, impaired remyelination and axonal loss lead to debilitating long-term neurologic deficits.
Marjan Gharagozloo +3 more
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Cell Reports, 2021 Summary: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability.
Kimberle Shen +9 more
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eLife, 2016 Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss.
Feng Mei +16 more
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