Results 91 to 100 of about 41,992 (300)

Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration

npj Regenerative Medicine
Regulation of myeloid cell activity is critical for successful myelin regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis (MS).
Jingwen Hu, George S. Melchor, Dimitrios Ladakis, Joan Reger, Hee Won Kim, Kelly A. Chamberlain, Nataliia V. Shults, Helena C. Oft, Victoria N. Smith, Lauren M. Rosko, Erqiu Li, Maryna Baydyuk, Meng-Meng Fu, Pavan Bhargava, Jeffrey K. Huang   +14 more
doaj   +1 more source

FGF/FGFR Pathways in Multiple Sclerosis and in Its Disease Models

Cells, 2021
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) affecting more than two million people worldwide.
Ranjithkumar Rajendran, Gregor Böttiger, Christine Stadelmann, Srikanth Karnati, Martin Berghoff   +4 more
doaj   +1 more source

Statin therapy inhibits remyelination in the central nervous system [PDF]

, 2009
Remyelination of lesions in the central nervous system contributes to neural repair following clinical relapses in multiple sclerosis. Remyelination is initiated by recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) into ...
Baron, Barry J. Bedell, Bruck, Cerghet, Chen, Decker, Dousset, Fancy, Garcia-Roman, Herman, Horner, Ito, Jack P. Antel, Johnson-Anuna, Jurevics, Kim, Kirsch, Kitada, Klopfleisch, Kondo, Kuhlmann, Kuhlmann, Lajtha, Leoni, Maeda, Maier, Matsushima, Miron, Paintlia, Pavlov, Prineas, Remington, Saheki, Saher, Samuel K. Ludwin, Sim, Simone P. Zehntner, Sun, Tanja Kuhlmann, Teunissen, Timothy E. Kennedy, Trevor Owens, Veronique E. Miron, Vollmer, Waxman, Windrem, Woodruff, Xiang, Youssef   +48 more
core   +2 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Remyelination protects neurons from DLK-mediated neurodegeneration

Nature Communications
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connections that drives progressive disability in demyelinating disease.
Greg J. Duncan, Sam D. Ingram, Katie Emberley, Jo Hill, Christian Cordano, Ahmed Abdelhak, Michael McCane, Jennifer E. Jenks, Nora Jabassini, Kirtana Ananth, Skylar J. Ferrara, Brittany Stedelin, Benjamin Sivyer, Sue A. Aicher, Thomas S. Scanlan, Trent A. Watkins, Anusha Mishra, Jonathan W. Nelson, Ari J. Green, Ben Emery   +19 more
doaj   +1 more source

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Acta Neuropathologica, 2019
Microglia are highly plastic immune cells which exist in a continuum of activation states. By shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which differentiate to myelin-forming cells, microglia participate in both ...
Marta Lombardi, Roberta Parolisi, Federica Scaroni, E. Bonfanti, A. Gualerzi, M. Gabrielli, N. Kerlero de Rosbo, A. Uccelli, P. Giussani, P. Viani, C. Garlanda, M. Abbracchio, L. Chaabane, A. Buffo, M. Fumagalli, C. Verderio   +15 more
semanticscholar   +1 more source

Human olfactory mesenchymal stromal cell transplants promote remyelination and earlier improvement in gait co-ordination after spinal cord injury [PDF]

, 2017
Autologous cell transplantation is a promising strategy for repair of the injured spinal cord. Here we have studied the repair potential of mesenchymal stromal cells isolated from the human olfactory mucosa after transplantation into a rodent model of ...
Barnett, Susan Carol, Emraja, Ahmed M.M., Griffin, Jacob, Lindsay, Susan L., Riddell, John, Toft, Andrew   +5 more
core   +1 more source

Silk fibroin‐based biomaterials for spinal cord injury repair: Recent advances and future prospects

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of silk fibroin‐based biomaterials in spinal cord injury repair, focusing on environmentally friendly processing techniques, and the strategies for designing composite scaffolds as well as discussing the advantages and current challenges of silk fibroin‐based biomaterials in spinal ...
Xiaoliang Cui, Xuanwen Wang, Siying Liu, Lilei Wang, Menghong Li, Jun Zhang, Li Wang, Ke‐Qin Zhang   +7 more
wiley   +1 more source

Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α

Cell Reports, 2018
Summary: Remyelination is a multistep regenerative process that results in the reformation of myelin sheaths around demyelinated axons and is a critical therapeutic target.
Samuel K. Jensen, Nathan J. Michaels, Slava Ilyntskyy, Michael B. Keough, Olga Kovalchuk, V. Wee Yong   +5 more
doaj   +1 more source

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Cell-specific and region-specific gene expression can identify therapeutic targets in different neuroanatomic regions during neurodegenerative diseases. Multiple sclerosis (MS) is multifocal, and neuroprotective treatments are needed.
R. Voskuhl, N. Itoh, A. Tassoni, M. Matsukawa, E. Ren, Vincent Tse, Ellis Jang, T. Suen, Y. Itoh   +8 more
semanticscholar   +1 more source