Results 101 to 110 of about 41,992 (300)
Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. [PDF]
, 2019 Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown.
Edgerton, V Reggie +19 more
core +1 more source
Glia, EarlyView.AAV‐BDNF improves cognitive performance after cuprizone‐induced de‐myelination. BDNF promotes OPC maturation and enhances remyelination in the corpus callosum. Mitochondrial integrity is preserved through reduced swelling and improved morphology. ABSTRACT Multiple sclerosis (MS) is a chronic neurological disorder involving immune‐mediated demyelination
Yousra El Ouaamari +14 more
wiley +1 more source
Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells. [PDF]
, 2019 Oligodendrocyte progenitor cells (OPCs) are a subtype of glial cells responsible for myelin regeneration. Oligodendrocytes (OLGs) originate from OPCs and are the myelinating cells in the central nervous system (CNS).
Casella, Giacomo +9 more
core +1 more source
Glia, EarlyView.Newly generated myelinating oligodendrocyte accumulation is decreased in the corpus callosum of aged mice. Morphological changes of newly generated myelinating oligodendrocytes in aged mice: greater height, shorter, and fewer myelin sheaths. ABSTRACT The activity of oligodendrocyte progenitor cells (OPCs) and oligodendrocytes (OLs) throughout life ...
Sasikarn Looprasertkul +3 more
wiley +1 more source
Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
eLifeRevealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyelinated lesions
Amber R Philp +20 more
doaj +1 more source
The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination. [PDF]
, 2014 Central nervous system remyelination by oligodendrocyte progenitor cells (OPCs) ultimately fails in the majority of multiple sclerosis (MS) lesions. Remyelination benefits from transient expression of factors that promote migration and proliferation of ...
Blaschuk KL +7 more
core +3 more sources
Glia, EarlyView.Hemizygous P0T124M mice develop a late‐onset axonopathy at 18 months of age. Pharmacological macrophage targeting with PLX5622 prevents distal axon degeneration in P0T124M mutant mice and mitigates motor impairment. ABSTRACT In several previous studies, we have shown that macrophage targeting with the CSF‐1 receptor specific kinase (c‐FMS) inhibitor ...
Dennis Klein +8 more
wiley +1 more source
Neurobiology of Disease, 2018 Remyelination is an endogenous regenerative process of myelin repair in the central nervous system (CNS) with limited efficacy in demyelinating disorders.
Gemma Llufriu-Dabén +12 more
doaj +1 more source
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination
Nature, 2018 Regeneration of myelin is mediated by oligodendrocyte progenitor cells—an abundant stem cell population in the central nervous system (CNS) and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the CNS
Zita M L Hubler +20 more
semanticscholar +1 more source
Disrupted CXCR2 Signaling in Oligodendroglia Lineage Cells Enhances Myelin Repair in a Viral Model of Multiple Sclerosis. [PDF]
, 2019 CXCR2 is a chemokine receptor expressed on oligodendroglia that has been implicated in the pathogenesis of neuroinflammatory demyelinating diseases as well as enhancement of the migration, proliferation, and myelin production by oligodendroglia. Using an
Cheng, Yuting +9 more
core +1 more source