Results 131 to 140 of about 41,992 (300)
Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease
Aging Cell, EarlyView.Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease‐Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single‐nucleus RNA‐seq from human brain tissues identified cholesterol‐related senescence gene co‐expression modules linked to microglial senescence.
Boyang Li +8 more
wiley +1 more source
CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents
Nature CommunicationsIn Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore fast saltatory conduction and neuroprotection but is inefficient in MS especially ...
Laura J. Wagstaff +6 more
doaj +1 more source
CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
Neuron, 2022 R. Franklin, M. Simons
semanticscholar +1 more source
P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
EMBO Molecular Medicine, 2018 Microglia survey the brain microenvironment for signals of injury or infection and are essential for the initiation and resolution of pathogen‐ or tissue damage‐induced inflammation.
Alazne Zabala +15 more
semanticscholar +1 more source
Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases
British Journal of Pharmacology, EarlyView.Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota +4 more
wiley +1 more source
Systemic TLR2 tolerance enhances central nervous system remyelination
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko +9 more
doaj +1 more source
Promoting remyelination in multiple sclerosis
Journal of Neurology, 2019 The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduction ...
Nick Cunniffe, A. Coles
semanticscholar +1 more source
Tyro3 deletion is protective in experimental autoimmune encephalomyelitis
Immunology &Cell Biology, EarlyView.Multiple sclerosis pathogenesis involves the complex interplay between the peripheral immune response and the central nervous system. Gas6 is a promising therapy to promote remyelination; however, Gas6 and its receptors (the TAM receptor family) are widely expressed in both immune cells and the central nervous system. Our study demonstrates that global
Michele D Binder +7 more
wiley +1 more source
Dynamic response of microglia/macrophage polarization following demyelination in mice
Journal of Neuroinflammation, 2019 Background The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function.
Tianci Chu +9 more
doaj +1 more source
PLoS Biology, 2019 The repair of white matter damage is of paramount importance for functional recovery after brain injuries. Here, we report that interleukin-4 (IL-4) promotes oligodendrocyte regeneration and remyelination.
Qingxiu Zhang +16 more
semanticscholar +1 more source