Results 11 to 20 of about 21,165 (234)

Age-impaired remyelination is associated with dysregulated microglial transitions [PDF]

Nature Communications
Multiple sclerosis (MS) is a chronic, inflammatory condition characterized by neurodegeneration and lost myelin, or demyelination. This lost myelin may be regenerated in people with MS through a process called remyelination, that is prone to failure and ...
Sameera Zia, Marianela E. Traetta, Charbel S. Baaklini, Brady P. Hammond, Rebecca K. John, Katherine M. Souter, Niels Meijns, Larry K. A. Afun, Sharmistha Panda, Fernando González Ibáñez, Mena K. Burr, Eva Dhupia, Abhisha M. Rathod, Andre O. Faria, Dhruvish Zaveri, Sowmya Challa, Eugene Hahn, Sohrab B. Manesh, Kelly V. Lee, Madelene F. S. Ho, Timothy N. Friedman, Aislinn D. Maguire, Arina Pang, Olivia Farkas, Bożena Szulc, Luiz Tenorio, Diya Vyas, Olivia R. La Caprara, Wolfram Tetzlaff, Sarthak Sinha, Gregory J. Duncan, Anastassia Voronova, Bradley J. Kerr, Marie-Eve Tremblay, Jeff Biernaskie, Geert Schenk, Jason R. Plemel   +36 more
doaj   +2 more sources

Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells [PDF]

Frontiers in Molecular Neuroscience, 2019
In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that surrounds axons, a process known as demyelination. The spontaneous regeneration of myelin, called remyelination, is associated with restoration of function and ...
Charbel S. Baaklini, Khalil S. Rawji, Greg J. Duncan, Madelene F. S. Ho, Jason R. Plemel   +4 more
doaj   +2 more sources

Activation of oligodendroglial Stat3 is required for efficient remyelination

Neurobiology of Disease, 2016
Multiple sclerosis is the most prevalent demyelinating disease of the central nervous system (CNS) and is histologically characterized by perivascular demyelination as well as neurodegeneration.
Andrew J. Steelman, Yun Zhou, Hisami Koito, SunJa Kim, H. Ross Payne, Q. Richard Lu, Jianrong Li   +6 more
doaj   +2 more sources

Hedgehog Signaling in CNS Remyelination

Cells, 2022
Remyelination is a fundamental repair process in the central nervous system (CNS) that is triggered by demyelinating events. In demyelinating diseases, oligodendrocytes (OLs) are targeted, leading to myelin loss, axonal damage, and severe functional ...
Minxi Fang, Tao Tang, Mengsheng Qiu, Xiaofeng Xu   +3 more
doaj   +4 more sources

Remyelination Therapy in Multiple Sclerosis [PDF]

Frontiers in Neurology, 2015
Multiple Sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration.
Danielle E. Harlow, Justin eHonce, Augusto A. Miravalle   +2 more
doaj   +3 more sources

Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4. [PDF]

J Neuroinflammation
Nolt GL, Golden LR, Thorpe SP, Funnell JL, Stephens IO, Hernandez G, MacLean SM, Lucido CC, Brock CR, Pallerla AV, Adreon DR, Williams HC, Morganti JM, Johnson LA.   +13 more
europepmc   +2 more sources

Spinal Cord Injury Remyelination: Pathways to Therapies. [PDF]

Int J Mol Sci
Kaniuk JK, Kumar D, Tennyson J, Hurka KL, Margolis A, Bucaloiu A, Selner A, Ahuja CS.   +7 more
europepmc   +3 more sources

Remyelination Trials [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2021
Neuroaxonal loss is believed to underpin the progressive disability that characterizes multiple sclerosis (MS). While focal inflammatory demyelination is a principal cause of acute axonal transection and subsequent axonal degeneration, the gradual attrition of permanently demyelinated axons may also contribute to tissue damage, particularly in the ...
Klistorner, Alexandr, Barnett, Michael
openaire   +2 more sources

Microglia promote remyelination independent of their role in clearing myelin debris

Cell Reports, 2023
Summary: Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination.
Charbel S. Baaklini, Madelene F.S. Ho, Tristan Lange, Brady P. Hammond, Sharmistha P. Panda, Martin Zirngibl, Sameera Zia, Kassandre Himmelsbach, Heli Rana, Braxton Phillips, Daria Antoszko, Jeremies Ibanga, Mizuki Lopez, Kelly V. Lee, Michael B. Keough, Andrew V. Caprariello, Bradley J. Kerr, Jason R. Plemel   +17 more
doaj   +1 more source

Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration

Frontiers in Molecular Neuroscience, 2023
Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains over the past decade with many regeneration strategies undergoing tested in
Davin Packer, Emily E. Fresenko, Em P. Harrington   +2 more
doaj   +1 more source