Results 11 to 20 of about 41,992 (300)
TREM2‐dependent microglial function is essential for remyelination and subsequent neuroprotection
Glia, 2023 Disability in multiple sclerosis (MS) is driven in part by the failure of remyelination and progressive neurodegeneration. Microglia, and specifically triggering receptor expressed on myeloid cells 2 (TREM2), a factor highly expressed in microglia, have ...
Yuanyuan Wang +11 more
semanticscholar +1 more source
Mechanisms of Demyelination and Remyelination Strategies for Multiple Sclerosis
International Journal of Molecular Sciences, 2023 All currently licensed medications for multiple sclerosis (MS) target the immune system. Albeit promising preclinical results demonstrated disease amelioration and remyelination enhancement via modulating oligodendrocyte lineage cells, most drug ...
Xinda Zhao, C. Jacob
semanticscholar +1 more source
Microglia promote remyelination independent of their role in clearing myelin debris
Cell Reports, 2023 Summary: Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination.
Charbel S. Baaklini +17 more
doaj +1 more source
Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration
Frontiers in Molecular Neuroscience, 2023 Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains over the past decade with many regeneration strategies undergoing tested in
Davin Packer +2 more
doaj +1 more source
Nature Communications, 2022 The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The molecular players that can enhance OPC differentiation
Xiao-Ru Ma +24 more
semanticscholar +1 more source
Brain : a journal of neurology, 2022 Promoting remyelination in order to prevent/reduce neurodegeneration in patients with multiple sclerosis (MS) is a major therapeutic goal. The longstanding view that the block of oligodendrocyte progenitor cell (OPC) differentiation in MS lesions is the ...
V. Tepavčević, C. Lubetzki
semanticscholar +1 more source
Brain : a journal of neurology, 2022 Many biomarkers in clinical neuroscience lack pathological certification. This issue is potentially a significant contributor to the limited success of neuroprotective and neurorestorative therapies for human neurological disease - and is evident even in
C. Cordano +10 more
semanticscholar +1 more source
In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis
eLife, 2023 Remyelination is crucial to recover from inflammatory demyelination in multiple sclerosis (MS). Investigating remyelination in vivo using magnetic resonance imaging (MRI) is difficult in MS, where collecting serial short-interval scans is challenging ...
Maxime Donadieu +14 more
doaj +1 more source
The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis.
Brain : a journal of neurology, 2021 Remyelination failure contributes to axonal loss and progression of disability in multiple sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to an inhibitory lesion microenvironment that prevents recruitment and/or ...
S. Ghorbani, V. Yong
semanticscholar +1 more source
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination
Journal of Experimental Medicine, 2021 Remyelination requires the clearance of cholesterol-rich myelin debris within demyelinating lesions by phagocytes. Gouna et al. found that TREM2-dependent formation of lipid droplets is necessary to buffer excess lipids released by myelin injury and ...
Garyfallia Gouna +7 more
semanticscholar +1 more source