Results 21 to 30 of about 21,165 (234)
In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis
eLife, 2023 Remyelination is crucial to recover from inflammatory demyelination in multiple sclerosis (MS). Investigating remyelination in vivo using magnetic resonance imaging (MRI) is difficult in MS, where collecting serial short-interval scans is challenging ...
Maxime Donadieu +14 more
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Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis
Frontiers in Molecular Neuroscience, 2022 Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). In people with MS, impaired remyelination and axonal loss lead to debilitating long-term neurologic deficits.
Marjan Gharagozloo +3 more
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Cell Reports, 2021 Summary: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability.
Kimberle Shen +9 more
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Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model
Cells, 2020 To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice. This
Stefan Gingele +7 more
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eLife, 2016 Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss.
Feng Mei +16 more
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A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
PLoS ONE, 2021 Incomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ ...
Intakhar Ahmad +3 more
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Brain region dependent molecular signatures and myelin repair following chronic demyelination
Frontiers in Cellular Neuroscience, 2023 Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system, characterized by myelin destruction, axonal degeneration, and progressive loss of neurological functions.
Grace Samtani +8 more
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Neurobiology of Disease, 2008 Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a ligand for αV integrins, several of which regulate the properties of the ...
Chao Zhao +3 more
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A New Model of Cuprizone-Mediated Demyelination/Remyelination
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs +4 more
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High throughput remyelination [PDF]
Science-Business eXchange, 2014 Remyelinating compounds have been difficult to identify in part because of a dearth of suitable high throughput screening platforms. UCSF researchers have now developed an assay that can identify active compounds and have licensed it to the build-to-buy incubator company Inception 5, which has partnered with Roche.
Kai-Jye Lou, Lev Osherovich
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