Results 21 to 30 of about 41,992 (300)

Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration.

Brain : a journal of neurology, 2022
In multiple sclerosis, spontaneous remyelination is generally incomplete and heterogenous across patients. A high heterogeneity in remyelination may also exist across lesions within the same individual, suggesting the presence of local factors ...
Matteo Tonietto, Emilie Poirion, A. Lazzarotto, Vito A G Ricigliano, C. Papeix, M. Bottlaender, B. Bodini, B. Stankoff   +7 more
semanticscholar   +1 more source

Motor Learning Promotes Remyelination via New and Surviving Oligodendrocytes

Nature Neuroscience, 2020
Oligodendrocyte loss in neurological disease leaves axons vulnerable to damage and degeneration, and activity-dependent myelination may represent an endogenous mechanism to improve remyelination following injury.
Clara M. Bacmeister, Helena J. Barr, Crystal R. McClain, Michael A. Thornton, Dailey Nettles, C. Welle, Ethan G. Hughes   +6 more
semanticscholar   +1 more source

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches. [PDF]

Neuropsychopharmacol Rep
Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Rajabi M, Shafaeibajestan S, Asadpour S, Alyari G, Taei N, Kohkalani M, Raoufinia R, Afarande H, Saburi E.   +8 more
europepmc   +2 more sources

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Acta Neuropathologica, 2020
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms.
Francesca Cignarella, Fabia Filipello, Bryan Bollman, C. Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, B. Benitez, Carlos Cruchaga, Danilo Licastro, K. Mihindukulasuriya, O. Harari, M. Buckland, D. Holtzman, A. Rosenthal, T. Schwabe, Ilaria Tassi, L. Piccio   +19 more
semanticscholar   +1 more source

Central nervous system regeneration: the roles of glial cells in the potential molecular mechanism underlying remyelination

Inflammation and Regeneration, 2022
Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous system (CNS) injuries and diseases. However, the roles of these cells and the molecular mechanisms toward regeneration in the CNS have not been fully understood ...
Lili Quan, Akiko Uyeda, R. Muramatsu
semanticscholar   +1 more source

Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model

Cells, 2020
To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice. This
Stefan Gingele, Florian Henkel, Sandra Heckers, Thiemo M. Moellenkamp, Martin W. Hümmert, Thomas Skripuletz, Martin Stangel, Viktoria Gudi   +7 more
doaj   +1 more source

Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination

Nature Communications, 2022
Remyelination failure in multiple sclerosis (MS) contributes to progression of disability. The deficient repair results from neuroinflammation and deposition of inhibitors including chondroitin sulfate proteoglycans (CSPGs).
S. Ghorbani, Emily Jelinek, Rajiv W Jain, B. Buehner, Cenxiao Li, Brian M. Lozinski, S. Sarkar, D. K. Kaushik, Yifei Dong, T. Wight, Soheila Karimi-Abdolrezaee, G. Schenk, E. Strijbis, J. Geurts, Ping Zhang, Chang-Chun Ling, V. Yong   +16 more
semanticscholar   +1 more source

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

eLife, 2016
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss.
Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan   +16 more
doaj   +1 more source

A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.

PLoS ONE, 2021
Incomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ ...
Intakhar Ahmad, Stig Wergeland, Eystein Oveland, Lars Bø   +3 more
doaj   +1 more source

Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models

Neurology: Neuroimmunology & Neuroinflammation, 2022
Background and Objectives Siponimod is an oral, selective sphingosine-1-phosphate receptor-1/5 modulator approved for treatment of multiple sclerosis. Methods Mouse MRI was used to investigate remyelination in the cuprizone model.
Michael Dietrich, Christina Hecker, E. Martin, D. Langui, M. Gliem, B. Stankoff, C. Lubetzki, J. Gruchot, Peter Göttle, Andrea Issberner, Milad Nasiri, Pamela Ramseier, C. Beerli, Sarah Tisserand, N. Beckmann, D. Shimshek, Patrick Petzsch, David Akbar, B. Levkau, H. Stark, K. Köhrer, H. Hartung, P. Küry, S. Meuth, M. Bigaud, B. Zalc, P. Albrecht   +26 more
semanticscholar   +1 more source