Results 41 to 50 of about 95 (92)
Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study
Annals of Neurology, Volume 97, Issue 6, Page 1074-1087, June 2025.Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern.
Dimitrios Papadopoulos +8 more
wiley +1 more source
Unexpected Remyelination in the Absence of Matrix Metalloproteinase 7
Glia, Volume 73, Issue 6, Page 1288-1306, June 2025.Main Points MMP7 is not essential for demyelination and remyelination in the cuprizone model. MMP7‐/‐ mice fibronectin aggregates do not accumulate in the remyelination phase. MMP7‐/‐ mice have lower levels of fibronectin and hyaluronan after chronic demyelination.
Rianne P. Gorter +7 more
wiley +1 more source
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
Role of Imaging in Chronic Inflammatory Demyelinating Polyneuropathy: A Systematic Review
European Journal of Neurology, Volume 32, Issue 6, June 2025.ABSTRACT Introduction Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a treatable immune‐mediated neuropathy with a relapsing‐remitting course and symmetrical proximal and distal weakness. Diagnosis relies on nerve conduction studies (NCS) to detect demyelination but can be difficult in atypical cases.
Stefano Tozza +5 more
wiley +1 more source
Neural Metabolic Networks: Key Elements of Healthy Brain Function
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer +20 more
wiley +1 more source
Growth factors and remyelination in the CNS.
Histology and histopathology, 1997 It is now well established that there is an inherent capacity within the central nervous system (CNS) to remyelinate areas of white matter that have undergone demyelination. However this repair process is not universally consistent or sustained, and persistent demyelination occurs in a number of situations, most notably in the chronic multiple ...
Woodruff, R.H., Franklin, R.J.M.
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Macrophages and CNS remyelination
Journal of Neurochemistry, 2014AbstractMicroglia are the resident macrophages of the central nervous system that survey the microenvironment for signals of injury or infection. The response to such signals induces an inflammatory response involving macrophages derived from both resident microglia and recruited circulating monocytes.
Veronique E Miron +2 more
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Imaging of remyelination [PDF]
Multiple Sclerosis Journal, 1997 Now that the concept of remyelination is gaining acceptance in MS, there is a need for a paraclinical marker to monitor remyelination in MS, for example to study the effect of therapeutical interventions. At present there is no known imaging marker for remyelination.
openaire +2 more sources