Results 41 to 50 of about 21,165 (234)

Oligodendroglial primary cilium heterogeneity during development and demyelination/remyelination

Frontiers in Cellular Neuroscience, 2022
The primary cilium (PC) has emerged as an indispensable cellular antenna essential for signal transduction of important cell signaling pathways. The rapid acquisition of knowledge about PC biology has raised attention to PC as a therapeutic target in ...
Giada Delfino, Giada Delfino, Giada Delfino, Karelle Bénardais, Karelle Bénardais, Karelle Bénardais, Karelle Bénardais, Julien Graff, Julien Graff, Brigitte Samama, Brigitte Samama, Brigitte Samama, Brigitte Samama, Maria Cristina Antal, Maria Cristina Antal, Maria Cristina Antal, Maria Cristina Antal, M. Said Ghandour, M. Said Ghandour, Nelly Boehm, Nelly Boehm, Nelly Boehm, Nelly Boehm   +22 more
doaj   +1 more source

Remyelination Therapy for Multiple Sclerosis [PDF]

Neurotherapeutics, 2013
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by infiltration of immune cells and progressive damage to myelin and axons. All therapeutics used to treat MS have been developed to target an overactive immune response, with aims to reduce disease activity.
Michael B, Keough, V Wee, Yong
openaire   +2 more sources

Daratumumab Treatment for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated neuropathy featuring progressive weakness, sensory deficits, and areflexia. While corticosteroids, intravenous immunoglobulin, and plasmapheresis are effective first‐line immunotherapies, a subset of patients remains treatment‐refractory.
Xueyu Zhang, Jianli Zhao, Xue Zhao, Xiaowei Hu, Zichun Xiao, Jie Wu, Xiaowen Li, Jing Xu, Yu‐Jing Li   +8 more
wiley   +1 more source

Efficient Remyelination Requires DNA Methylation [PDF]

eneuro, 2017
Oligodendrocyte progenitor cells (OPCs) are the principal source of new myelin in the central nervous system. A better understanding of how they mature into myelin-forming cells is of high relevance for remyelination. It has recently been demonstrated that during developmental myelination, the DNA methyltransferase 1 (DNMT1), but ...
Sarah Moyon, Dan Ma, Jimmy L. Huynh, David J.C. Coutts, Chao Zhao, Patrizia Casaccia, Robin J.M. Franklin   +6 more
openaire   +3 more sources

Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber.

PLoS ONE, 2017
Demyelination is observed in numerous diseases of the central nervous system, including multiple sclerosis (MS). However, the endogenous regenerative process of remyelination can replace myelin lost in disease, and in various animal models. Unfortunately,
Marja J Karttunen, Tim Czopka, Marieke Goedhart, Jason J Early, David A Lyons   +4 more
doaj   +1 more source

Regenerative Capacity of Macrophages for Remyelination

Frontiers in Cell and Developmental Biology, 2016
White matter injury, consisting of loss of axons, myelin and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is
Khalil eRawji, Manoj eMishra, V Wee eYong   +2 more
doaj   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Combination therapy dramatically promotes remyelination. [PDF]

J Mol Cell Biol
Abstract Multiple sclerosis (MS) is an immune-mediated disease in the central nervous system that is characterized by demyelination, axonal degeneration, and progressive neurological disability and is so far incurable. Current medications are predominantly immune-targeted but fail to prevent disease progression due to their inability ...
Li Y, Li P, Song Y, Zhang W, Jiang X, Chen S, Luo W, Ma C, Liu C, Niu J, Liang A, Du Y, Zhou BO, Zhang M.   +13 more
europepmc   +4 more sources

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Remyelinating Pharmacotherapies in Multiple Sclerosis [PDF]

Neurotherapeutics, 2017
We have witnessed major successes in the development of effective immunomodulatory therapies capable of reducing adaptive immune-mediated myelin damage in MS over the last 30 years. However, until it is possible to prevent MS or initiate treatment before it has already caused lesions there is a need to repair myelin damage to prevent further axonal ...
Riley M. Bove, Ari J Green
openaire   +4 more sources