Results 51 to 60 of about 95 (92)
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REMYELINATION IN MULTIPLE SCLEROSIS
Journal of Neuropathology and Experimental Neurology, 1978AbstractChronic plaques in central nervous system tissue fixed by in situe perfusion for electron microscopy were examined for evidence of remyelination in 2 patients with multiple sclerosis (MS). Fibers with abnormal central myelin sheaths of several types were found at the margins of most of the plaques studied. The most common of these were: (1) the
F. Connell +3 more
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Pattern of Remyelination in the CNS
Nature, 1973FOR more than a decade it has been known1–3 that glial cells are capable of forming new myelin sheaths around demye-linated axons in the central nervous system (CNS) but it is not known whether the new myelin is formed into segments bounded by true nodes and, if it is, whether the internodal length is appropriate to the axon diameter or inappropriately
B. M. Harrison +2 more
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NeuroReport, 2002
Remyelination of demyelinated axons in the CNS is a regenerative process that, like many others, becomes less efficient with age. This article reviews a series of studies in which toxin models of demyelination have been used to characterize this phenomenon.
Chao Zhao +2 more
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Remyelination of demyelinated axons in the CNS is a regenerative process that, like many others, becomes less efficient with age. This article reviews a series of studies in which toxin models of demyelination have been used to characterize this phenomenon.
Chao Zhao +2 more
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Remyelination in multiple sclerosis
Multiple Sclerosis Journal, 1997Stimulation of remyelination in multiple sclerosis lesions may be one possible therapeutic approach. However, since the pathology and pathogenesis of multiple sclerosis may be heterogeneous, it is important to analyze in what patients and at what stages of the disease such a therapy can be reasonable and feasible.
Wolfgang Brück +3 more
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Pattern of remyelination in the CNS
Nature, 1974IT has been suggested that reduction of internodal length may be a feature of remyelinated central nerve fibres as it is of peripheral nerve fibres1. As the technique for measuring internodal length of nerve fibres in the central nervous system (CNS) is tedious and requires a high degree of skill and patience from the investigator2, it is unlikely that
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The role of NCAM in remyelination
Neurological Sciences, 2002The neural cell adhesion molecule (NCAM) is expressed by myelinating precursor cells in neonatal mouse spinal cord and by remyelinating cells after chemically induced demyelination in adult mouse. It shows tempting suggestions about its possible involvement in the reparative mechanisms and the remyelination processes that take place in multiple ...
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Remyelination in multiple sclerosis
2009Remyelination in multiple sclerosis is in most cases insufficient, leading to irreversible disability. Different and nonexclusive factors account for this repair deficit. Local inhibitors of the differentiation of oligodendrocyte progenitor cells (OPCs) might play a role, as well as axonal factors impairing the wrapping process. Alternatively, a defect
Gabrièle Piaton +3 more
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Science Signaling, 2013
Inhibiting SIRT1 may improve demyelinating neuropathies by inducing the expansion of myelin-producing oligodendrocytes.
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Inhibiting SIRT1 may improve demyelinating neuropathies by inducing the expansion of myelin-producing oligodendrocytes.
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THE RESTORATION OF CONDUCTION BY CENTRAL REMYELINATION
Brain, 1981Conduction has been examined serially through the experimental demyelinating lesion produced by the direct micro-injection of lysophatidyl choline into the cat spinal cord. Conduction was blocked during the phase of demyelination. Remyelination commenced during the latter part of the second week, and conduction through the lesion was restored in some ...
W.F. Blakemore +2 more
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Mechanisms and Medicines for Remyelination
Annual Review of Medicine, 2017Demyelination of central nervous system axons, associated with traumatic injury and demyelinating diseases such as multiple sclerosis, causes impaired neural transmission and ultimately axon degeneration. Consequently, extensive research has focused on signaling systems that promote myelinating activity of oligodendrocytes or promote production of new
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