Results 61 to 70 of about 95 (92)
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Remyelination — An effective means of neuroprotection
Hormones and Behavior, 2010Remyelination following central nervous system (CNS) demyelination restores rapid saltatory conduction of action potentials and contributes to the maintenance of axonal integrity. This robust regenerative phenomenon stands in contrast to the limited repair capacity that is characteristic of CNS neuronal injury.
Charlotte C. Bruce +2 more
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Imaging of Remyelination and Neuronal Health [PDF]
, 2008 Remyelination of axons that have been demyelinated due to multiple sclerosis (MS) may be a critical step in restoring the damaged axons and reversing the disease process. While it is possible to establish the presence of remyelination with microscopy of tissue samples, it is important to have noninvasive or minimally invasive methods to measure ...
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Endogenous or exogenous oligodendrocytes for remyelination
Journal of the Neurological Sciences, 2008The relative merits of endogenous and exogenous oligodendrocyte progenitor cells (OPCs) for remyelination are compared in terms of their ability to repopulate OPC-depleted tissue and generate remyelinating oligodendrocytes. Exogenous neonatal OPCs can repopulate OPC-depleted tissue 5-10 times faster than endogenous cells and as a result are capable of ...
Karen-Amanda Irvine +1 more
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Transcriptional control of myelination and remyelination
Glia, 2019AbstractMyelination is an evolutionary recent differentiation program that has been independently acquired in vertebrates by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. Therefore, it is not surprising that regulating transcription factors differ substantially between both cell types.
Elisabeth Sock, Michael Wegner
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Remyelination: Cellular and gene therapy
Seminars in Pediatric Neurology, 1998Dysfunctional myelination or oligodendroglial abnormalities play a prominent role in a vast array of pediatric neurological diseases of genetic, inflammatory, immunological, traumatic, ischemic, developmental, metabolic, and infectious causes. Recent advances in glial cell biology have suggested that effective remyelination strategies may, indeed, be ...
Rosanne M. Taylor +5 more
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Remyelination in the CNS of the hypothyroid rat
NeuroReport, 1996A number of studies have provided good evidence to indicate a role for thyroid hormone in myelination. Since myelination and remyelination have many shared objectives, and may therefore involve similar mechanisms, we examined whether thyroid hormone may also have a role in remyelination by both Schwann cells and oligodendrocytes of spinal cord axons ...
Jennifer M. Gilson, Robin J.M. Franklin
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Remyelination in the chicken sciatic nerve
Neurochemistry International, 1982Remyelination in the chicken sciatic nerve occurring after the injection of diphtheria toxin was studied. The rates of fast axonal transport and conduction velocities were measured sixty days after the injection of the toxin. Fast axonal transport rates were found to have returned to normal in the remyelinated nerves, but conduction velocity was ...
Neil A. Cooper +2 more
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Remyelinating the demyelinated CNS.
Novartis Foundation symposium, 2000The CNS has an inherent capacity to generate remyelinating cells following episodes of myelin loss. However, persistent demyelination is the major pathology of multiple sclerosis and the leucodystrophies, and is also a feature of spinal cord trauma.
Peter Smith +3 more
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Review of the Morphological Aspects of Remyelination
Developmental Neuroscience, 1989The advent of proper preparative and experimental techniques has allowed us to investigate the central nervous system myelin both in the normal animal and during remyelination. Remyelination often follows the pattern of myelination during development but, in addition, shows certain variations such as participation of Schwann cells, and is apparently ...
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TREM2 activation promotes remyelination
Nature Reviews Neurology, 2020Cignarella, F. et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathol. https://doi.org/10.1007/s00401-020-02193-z (2020) Article PubMed Google Scholar Ulland, T. K. & Colonna, M. TREM2 — a key player in microglial biology and Alzheimer disease. Nat. Rev. Neurol. 14, 667–
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