Results 71 to 80 of about 41,992 (300)

Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Journal of Neuroinflammation, 2023
Highlights AhR regulates remyelination following cuprizone-induced demyelination. Deletion of AhR in adult microglia restrains efficient remyelination.
Yumeng Wang, Jingxian Sun, Keying Zhu, Danjie Wang, Xiaoqiang Zhao, Hongyu Zhang, Shuai Wu, Yanqing Wang, Jun Wang   +8 more
doaj   +1 more source

3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine

Advanced Materials, EarlyView.
This perspective article discusses how 3D bioprinting is advancing the development of neural tissue models and implants. It highlights recent progress in fabricating complex, multicellular neural constructs, examines current technical barriers, and outlines future applications in disease modeling, neurotoxicity testing, and regenerative therapies ...
Mitchell St Clair‐Glover, Zhilian Yue, Mirella Dottori   +2 more
wiley   +1 more source

Remyelination in multiple sclerosis from the miRNA perspective

Frontiers in Molecular Neuroscience, 2023
Remyelination relies on the repair of damaged myelin sheaths, involving microglia cells, oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes.
Karina Maciak, Angela Dziedzic, Joanna Saluk   +2 more
doaj   +1 more source

Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination

Journal of Neuroinflammation, 2020
Intracerebral hemorrhage (ICH) can induce excessive accumulation of reactive oxygen species (ROS) that may subsequently cause severe white matter injury.
Jingwei Zheng, Jianan Lu, Shuhao Mei, Haijian Wu, Zeyu Sun, Yuanjian Fang, Shenbin Xu, Xiaoyu Wang, Ligen Shi, Weilin Xu, Sheng Chen, Jun Yu, Feng Liang, Jianmin Zhang   +13 more
semanticscholar   +1 more source

BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis

Brain : a journal of neurology, 2021
Extrinsic inhibitors at sites of blood–brain barrier disruption and neurovascular damage contribute to remyelination failure in neurological diseases. However, therapies to overcome the extrinsic inhibition of remyelination are not widely available and ...
Mark A. Petersen, Reshmi Tognatta, A. Meyer‐Franke, E. Bushong, Andrew S. Mendiola, Zhaoqi Yan, Abinaya Muthusamy, M. Merlini, R. Meza-Acevedo, Belinda S. Cabriga, Yungui Zhou, Reuben Thomas, J. Ryu, H. Lassmann, Mark Ellisman, K. Akassoglou   +15 more
semanticscholar   +1 more source

Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury. [PDF]

, 2018
BACKGROUND:In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9 performs essential functions in the acute response to injury. Whether MMP-9 activity contributes to late-phase injury or whether MMP-9 expression or activity after ...
Angert, Mila, Chernov, Andrei V, Dolkas, Jennifer, Hullugundi, Swathi K, Remacle, Albert G, Shubayev, Veronica I, Strongin, Alex Y   +6 more
core   +2 more sources

Aligned Conductive Magnetic Nanofibers with Directional Magnetic Field Stimulation Promotes Peripheral Nerve Regeneration

Advanced Science, EarlyView.
Peripheral nerve injury necessitates alternatives to autografts. This study combines magnetic nanoparticles, oriented PCL fibers, and Ppy to create a conductive, magnetically active scaffold. In vitro and in vivo experiments demonstrated enhanced downstream pathways of calcium signaling, as revealed by transcriptome analysis.
Zheyuan Fan, Wei Yu, Xinggui Wen, Xiangdong Ding, Xiang Li   +4 more
wiley   +1 more source

A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Current immunomodulatory therapies for multiple sclerosis (MS) can effectively inhibit autoimmune response, but largely fail to promote myelin repair.
Y. Zhang, Xing Li, B. Ciric, M. Curtis, Wanjun Chen, A. Rostami, Guang-Xian Zhang   +6 more
semanticscholar   +1 more source

Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis. [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Rivera, Francisco J
core   +2 more sources

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source