Results 81 to 90 of about 41,992 (300)

Myelin Damage and Repair in Pathologic CNS: Challenges and Prospects

Frontiers in Molecular Neuroscience, 2015
Injury to the central nervous system (CNS) results in oligodendrocyte cell death and progressive demyelination. Demyelinated axons undergo considerable physiological changes and molecular reorganizations that collectively result in axonal dysfunction ...
Arsalan eAlizadeh, Scott M. Dyck, Soheila eKarimi-Abdolrezaee   +2 more
doaj   +1 more source

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

eLife, 2021
The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhancing
Yanan Chen, Rejani B Kunjamma, Molly Weiner, Jonah R Chan, Brian Popko   +4 more
doaj   +1 more source

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance We identify cellular senescence occurring in neural progenitor cells (NPCs) from primary progressive multiple sclerosis (PPMS). In this study, senescent progenitor cells were identified within demyelinated white matter lesions in progressive
A. Nicaise, L. Wagstaff, Cory M Willis, Carolyn Paisie, Harshpreet Chandok, P. Robson, V. Fossati, Anna C. Williams, S. Crocker   +8 more
semanticscholar   +1 more source

mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model

Journal of Neuroscience, 2021
In demyelinating diseases, such as multiple sclerosis, primary loss of myelin and subsequent neuronal degeneration throughout the CNS impair patient functionality.
Marisa A. Jeffries, Lauren E. McLane, Luipa Khandker, Marie L. Mather, A. Evangelou, Divyangi Kantak, Jennifer N. Bourne, W. Macklin, T. Wood   +8 more
semanticscholar   +1 more source

FSD-C10, a Fasudil derivative, promotes neuroregeneration through indirect and direct mechanisms. [PDF]

, 2017
FSD-C10, a Fasudil derivative, was shown to reduce severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through the modulation of the immune response and induction of neuroprotective molecules in the ...
Chai, Zhi, Li, Xing, Li, Yan-Hua, Ma, Cun-Gen, Thome, Rodolfo, Wang, Qing, Xiao, Bao-Guo, Xie, Chong, Zhang, Guang-Xian, Zhang, Hai-Fei, Zhang, Yuan   +10 more
core   +2 more sources

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source

Butyrate suppresses demyelination and enhances remyelination

Journal of Neuroinflammation, 2019
The association of gut microbiota and diseases of the central nervous system (CNS), including multiple sclerosis (MS), has attracted much attention. Although a previous analysis of MS gut microbiota revealed a reduction in species producing short-chain ...
Tong Chen, D. Noto, Y. Hoshino, M. Mizuno, S. Miyake   +4 more
semanticscholar   +1 more source

Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination

ASN Neuro, 2020
Iron is a key nutrient for normal central nervous system (CNS) development and function; thus, iron deficiency as well as iron excess may result in harmful effects in the CNS. Oligodendrocytes and astrocytes are crucial players in brain iron equilibrium.
V. Cheli, J. Correale, P. Paez, J. Pasquini   +3 more
semanticscholar   +1 more source

Monocytes in central nervous system remyelination

Glia, 2021
Remyelination failure with aging and progression of neurodegenerative disorders contributes to axonal dysfunction, highlighting the importance of understanding the mechanisms underpinning this process to develop regenerative therapies.
Lindsey H. Forbes, V. Miron
semanticscholar   +1 more source

Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long‐Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells

Advanced Science, EarlyView.
This study identifies akermanite among six bioceramics and reveals its ability to enhance Schwann cell's proliferation, migration, and secretion. When combined with silk sericin, the composite conduit synergistically enhances Schwann cell‐mediated regenerative processes.
Qiangfei Su, Jian Wang, Yu Song, Zhaowenbin Zhang, Bo Cai, Xiakeerzhati Xiaohalati, Jingwei Liu, Haozhe Li, Zheng Wang, Jiang Chang, Lin Wang   +10 more
wiley   +1 more source