Results 61 to 70 of about 624,431 (182)

Hypouricemia is a risk factor for diabetes in Chinese adults [PDF]

, 2022
Aims: It is unknown whether low serum uric acid (hypouricemia) is associated with diabetes diagnosis. This study aimed to investigate this association in Chinese adults. Methods: This cross-sectional study included 22,546 Chinese adults. The reference
Qian, Tingting, Golledge, Jonathan, Qun Xu, Fang, Yan, Dianna J. Magliano, Wenqi Hu, Magliano, Dianna J., Hou, Xujuan, Song, David, Magliano, Dianna, Hui Sun, Sun, Hui, Hu, Wenqi, Jonathan Golledge, Guang Yang, Yutang Wang, Yanan Shao, Wang, Yutang, Tingting Qian, Yan Fang, Shao, Yanan, Zhang, Guang, Witting, Paul, Yang, Guang, Paul K. Witting, Witting, Paul K., Guang Zhang, David Song, Xujuan Hou, Xu, Qun   +29 more
core   +1 more source

Novel Genetic Loci in Early‐Onset Gout Derived From Whole‐Genome Sequencing of an Adolescent Gout Cohort

Arthritis &Rheumatology, Volume 77, Issue 1, Page 107-115, January 2025.
Objective Mechanisms underlying the adolescent‐onset and early‐onset gout are unclear. This study aimed to discover variants associated with early‐onset gout. Methods We conducted whole‐genome sequencing in a discovery adolescent‐onset gout cohort of 905 individuals (gout onset 12 to 19 years) to discover common and low‐frequency single‐nucleotide ...
Aichang Ji, Yang Sui, Xiaomei Xue, Xiapeng Ji, Wenrui Shi, Yongyong Shi, Robert Terkeltaub, Nicola Dalbeth, Riku Takei, Fei Yan, Mingshu Sun, Maichao Li, Jie Lu, Lingling Cui, Zhen Liu, Can Wang, Xinde Li, Lin Han, Zhanjie Fang, Wenyan Sun, Yue Liang, Yuwei He, Guangmin Zheng, Xuefeng Wang, Jiayi Wang, Hui Zhang, Lei Pang, Han Qi, Yushuang Li, Zan Cheng, Zhiqiang Li, Jingfa Xiao, Changqing Zeng, Tony R. Merriman, Hongzhu Qu, Xiangdong Fang, Changgui Li   +36 more
wiley   +1 more source

Benzbromarone Inhibits Renal URAT1 and Attenuates Renal Damage in Streptozotocin‐Induced Diabetic Rats, Independent of Its Uricosuric Effects

Journal of Diabetes Research, Volume 2025, Issue 1, 2025.
Background Hyperuricemia remains a critical risk factor for diabetic kidney disease (DKD) currently. Recent studies have confirmed that allopurinol, an inhibitor of xanthine oxidase (XO), does not have any beneficial effects on DKD. However, it is still unclear how uricosurics, such as benzbromarone (BZ), affect the progression of DKD.
Chuping Chen, Ping Zhu, Rongshao Tan, Yan Liu, Jianmin Ran, Hannah Wesley   +5 more
wiley   +1 more source

Duloxetine‐induced syndrome of inappropriate antidiuretic hormone secretion in a patient with neuropathic pain

Clinical Case Reports, Volume 12, Issue 11, November 2024.
Key Clinical Message Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induces hyponatremia accompanied by uric acid reduction. We report a case of a patient with small‐cell lung cancer who developed SIADH with hypouricemia after duloxetine treatment and discuss the potential underlying mechanisms.
Nobuyuki Takahashi, Yukiko Mori, Kenji Momo, Hidetomo Murakami, Hironori Tanaka   +4 more
wiley   +1 more source

URAT1 mutations cause renal hypouricemia type 1 in Iraqi Jews

, 2010
Background. Hereditary renal hypouricemia may be complicated by nephrolithiasis or exercise-induced acute renal failure. Most patients described so far are of Japanese origin and carry the truncating mutation W258X in the uric acid transporter URAT1 ...
G. Burckhardt, Sela, Ben-Ami, Burckhardt, Gerhard, Ganon, Liat, Ron, Rotem, E. J. Holtzman, R. Ron, R. Rachamimov, Knecht, Aaron, A. Bahn, Bahn, Andrew, D. Dinour, A. Knecht, O. Geifman-Holtzman, B.-A. Sela, Holtzman, Eliezer J., U. Gafter, Rachamimov, Ruth, L. Ganon, Gafter, Uzi, Geifman-Holtzman, Ossie, Dinour, Dganit   +21 more
core   +1 more source

Exercise-Induced Acute Kidney Injury: A Case of Renal Hypouricemia

Turkish Journal of Nephrology, 2019
Hereditary renal hypouricemia is a rare inherited disorder characterized by reduced tubular reabsorption of urate and low serum urate levels. Although it is usually asymptomatic, it may be complicated by exercise-induced acute kidney injury.
Simge BARDAK, Kenan TURGUTALP, Ahmet KIYKIM   +2 more
doaj  

Distribution and Characteristics of Hypouricemia within the Japanese General Population: A Cross-Sectional Study

Medicina, 2019
Background and objectives: There is insufficient epidemiological knowledge of hypouricemia. In this study, we aimed to describe the distribution and characteristics of Japanese subjects with hypouricemia.
Shin Kawasoe, Kazuki Ide, Tomoko Usui, Takuro Kubozono, Shiro Yoshifuku, Hironori Miyahara, Shigeho Maenohara, Mitsuru Ohishi, Koji Kawakami   +8 more
doaj   +1 more source

A case of idiopathic renal hypouricemia

Korean Journal of Pediatrics, 2007
Idiopathic renal hypouricemia is a disorder characterized by impaired urate handling in the renal tubules. This disease usually produces no symptoms, but hematuria, uric acid nephrolithiasis or acute renal failure may develop. A defect in the SLC22A12 gene, which encodes the human urate transporter, is the known major cause of this disorder.
Moon Hee Han, Sang Uk Park, Deok-Soo Kim, Jae Won Shim, Jung Yeon Shim, Hye Lym Jung, Moon Soo Park   +6 more
openaire   +1 more source

Clinical characteristics of acute renal failure with severe loin pain and patchy renal vasoconstriction

Kidney Research and Clinical Practice, 2012
Background: Acute renal failure (ARF) with severe loin pain and patchy renal vasoconstriction (PRV) is a syndrome presenting with sudden loin pain after anaerobic exercise.
Jeonghwan Lee, Seong Woo Lee, Jae Wook Lee, Ho Jun Chin, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Suhnggwon Kim, Jeong Yeon Cho, Jin Suk Han   +9 more
doaj   +1 more source

Consensus guidelines for the diagnosis and management of isolated sulfite oxidase deficiency and molybdenum cofactor deficiencies

Journal of Inherited Metabolic Disease, Volume 47, Issue 4, Page 598-623, July 2024.
Abstract Sulfite intoxication is the hallmark of four ultrarare disorders that are caused by impaired sulfite oxidase activity due to genetic defects in the synthesis of the molybdenum cofactor or of the apoenzyme sulfite oxidase. Delays on the diagnosis of these disorders are common and have been caused by their unspecific presentation of acute ...
Bernd C. Schwahn, Francjan van Spronsen, Albert Misko, Julija Pavaine, Victoria Holmes, Ronen Spiegel, Guenter Schwarz, Flora Wong, Alistair Horman, James Pitt, Jörn Oliver Sass, Charlotte Lubout   +11 more
wiley   +1 more source