Results 51 to 60 of about 624,431 (182)

Renal Tubular Hypouricemia and Calcium Urolithiasis [PDF]

, 1992
The information concerning the relationship of hypouricemia with urinary tract stones is limited. We investigated the incidence and types of hypouricemia, and also studied its relationship to urinary tract stones.
Kotake, Tadashi, Miura, Naoto, Ito, Haruo   +2 more
core   +1 more source

Lower time‐averaged serum uric acid was associated with increased mortality in peritoneal dialysis patients

Therapeutic Apheresis and Dialysis, Volume 29, Issue 3, Page 479-490, June 2025.
Abstract Background The relationship between time‐averaged serum uric acid (TA‐SUA) levels and prognosis in peritoneal dialysis (PD) patients are rarely discussed. Methods This was a retrospective cohort study. PD patients recruited from January 1, 2011, to December 31, 2020, were included.
Lu Li, Hongxia Zhang, Botao Zhang, Fangyuan Yang, Mengting Wang, Wenlong Qiu, Lina Fu, Menghua Chen, Na Tian   +8 more
wiley   +1 more source

Recurrent exercise-induced acute renal failure in a young Pakistani man with severe renal hypouricemia and SLC2A9 compound heterozygosity. [PDF]

, 2014
BACKGROUND: Familial renal hypouricemia (RHUC) is a hereditary disease characterized by hypouricemia, high renal fractional excretion of uric acid (FE-UA) and can be complicated by acute kidney failure and nephrolithiasis.
Possenti S, Gaggiotti M, Federica Verzeletti, MAIORCA, Paolo, Stefano Possenti, COLOMBI, Marina, Verzeletti F, Marco Ritelli, Paolo Maiorca, CANCARINI, Giovanni, Mario Gaggiotti, Nicola Chiarelli, CHIARELLI, Nicola, Marina Colombi, Guido Jeannin, Quinzani S, Ritelli M, Stefano Quinzani, Jeannin G, Giovanni Cancarini   +19 more
core   +2 more sources

Prevalence and complications of hypouricemia in a general population: A large-scale cross-sectional study in Japan.

PLoS ONE, 2017
BackgroundsHypouricemia was reported as a risk factor for exercise-induced acute renal injury (EIAKI) and urinary stones. However, the prevalence of kidney diseases among hypouricemic subjects has not been evaluated.
Masanari Kuwabara, Koichiro Niwa, Akira Ohtahara, Toshihiro Hamada, Satoshi Miyazaki, Einosuke Mizuta, Kazuhide Ogino, Ichiro Hisatome   +7 more
doaj   +1 more source

Two Cases of Renal Hypouricemia with Nephrolithiasis.

Internal Medicine, 1997
We treated two cases of renal hypouricemia with nephrolithiasis. The serum uric acid level of the first patient was 1.5 mg/dl, and the ratio of uric acid clearance to creatinine clearance (CUA/Ccr) was 75.7%. In the benzbromarone (BZB) suppression test, CUA/Ccr was increased from 60.4% to 130.0%, but was not decreased in response to the pyrazinamide ...
HIRASAKI, Shoji, KOIDE, Norio, FUJITA, Kiyoshi, OGAWA, Hiromichi, TSUJI, Takao   +4 more
openaire   +3 more sources

Clinical and biochemical profile of individuals with renal glucosuria: A matched cohort study

Diabetes, Obesity and Metabolism, Volume 27, Issue 6, Page 3242-3251, June 2025.
Abstract Aims To compare the clinical and biochemical characteristics of individuals with renal glucosuria to matched controls. Materials and Methods We analysed data from 60,000 consecutive adults in Maccabi Healthcare Services, an Israeli health maintenance organization, who had at least two urine dipstick tests performed at least 3 months apart ...
Afif Nakhleh, Limor Adler, Gida Ayada, Shirley Shapiro Ben David, Daniella Rahamim‐Cohen, Ori Liran, Sagit Zolotov, Naim Shehadeh   +7 more
wiley   +1 more source

Diagnosis of Inherited Metabolic Disease in Older Patients: A Systematic Literature Review

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT Inherited metabolic diseases (IMDs) are genetic disorders that disrupt biochemical processes in the human body, due to pathogenic variants in genes encoding enzymes or transporters. While IMDs are mostly diagnosed in infancy or childhood, there is an increasing number of diagnoses in adult patients.
Maria‐Rita Moio, Julia Cordeiro Milke, Yannick Moutapam‐Ngamby‐Adriaansen, Arthur Minas Alberti, Marie Gernay, Eduardo Augusto Schutz, Ida Vanessa Doederlein Schwartz, François Maillot   +7 more
wiley   +1 more source

Recurrent EIARF and PRES With Severe Renal Hypouricemia by Compound Heterozygous SLC2A9 Mutation

, 2011
Renal hypouricemia (RHU) is a hereditary disease that predisposes affected people to exercise-induced acute renal failure (EIARF). In most patients with RHU, the disorder is caused by loss-of-function mutations in SLC22A12 (solute carrier family 22 ...
Norishige Yoshikawa, Hiroshi Kaito, Hiroko Togawa, Yuko Shima, Kazumoto Iijima, Kandai Nozu, Koichi Nakanishi, Yoshimi Nozu, Masafumi Matsuo   +8 more
core   +1 more source

Renal hypouricemia: incomplete combined defect.

Nihon Jinzo Gakkai shi, 1994
A 20-year-old man with hypouricemia with markedly increased renal uric acid clearance is described. He also exhibited idiopathic hypercalciuria and lipoid nephrosis on hospital admission. Urate excretion was minimally suppressed by pyrazinamide and minimally increased after administration of probenecid, whereas it decreased after administration of ...
KAWAI, SHINICHIRO, YAMADA, MASHAHIKO, OSAWA, GENGO   +2 more
openaire   +2 more sources

Safety, Pharmacokinetics, and Pharmacodynamics of a First‐in‐Class ClC‐1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial

Clinical Pharmacology &Therapeutics, Volume 117, Issue 3, Page 768-778, March 2025.
NMD670 is a first‐in‐class inhibitor of skeletal muscle‐specific chloride channel ClC‐1, developed to improve muscle weakness and fatigue in neuromuscular diseases. Preclinical studies show that ClC‐1 inhibition enhances muscle excitability, improving muscle contractility and strength.
Titia Q. Ruijs, Catherine M. K. E. de Cuba, Jules A. A. C. Heuberger, John Hutchison, Jane Bold, Thomas S. Grønnebæk, Klaus G. Jensen, Eva Chin, Jorge A. Quiroz, Thomas K. Petersen, Peter Flagstad, Marieke L. de Kam, Michiel J. van Esdonk, Erica Klaassen, Robert J. Doll, Ingrid W. Koopmans, Annika A. de Goede, Linda B. S. Aulin, Thomas H. Pedersen, Geert Jan Groeneveld   +19 more
wiley   +1 more source