Results 1 to 10 of about 240,790 (255)
On the Specificity of Renin [PDF]
Science, 1940 Fil: Braun Menéndez, Eduardo. Instituto de Fisiología. Facultad de Medicina.
Fasciolo, Juan C. +3 more
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Journal of the Renin-Angiotensin-Aldosterone System, 2005 Renin is an aspartic protease that consists of 2 homologous lobes. The cleft in between contains the active site with 2 catalytic aspartic residues.1 Unlike other aspartic proteases such as pepsin or cathepsin D, renin is monospecific and only cleaves angiotensinogen, to generate angiotensin (Ang) I.
Friedrich C. Luft +9 more
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Renin, Renin Inhibition and Antihypertensive Therapy
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1983 Research over the last 25 years established the renin-angiotensin-aldosterone system's important role in electrolyte and blood pressure homeostasis as well as in the pathophysiology of hypertension for which renin suppressive drugs, angiotensin antagonists and converting enzyme inhibitors provided selective pharmacological tools.
F. R. Bühler +1 more
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Renin and Renin Inhibition in Anephric Man
Clinical and Experimental Hypertension, 1993 Renin activity appears to be present in low concentrations in the plasma of anephric humans but could be artifactual secondary to inadvertent activation of prorenin during specimen collection and handling or from a renin-like enzyme. We studied the effects of specimen collection, storage, different assay conditions, trypsin activation, and the renin ...
Robert D. Murray +4 more
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The Nature of Renin Precursor and Inactive Renin
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1982 The biosynthesis of renin in the mouse submaxillary gland was defined using both cell-free translation and pulse-labelling methods. Renin is synthesized as a preproform and cleaved by microsomes to the proform. Prorenin (MW = 46 kilodaltons, pI 6.35) is processed intracellulary into an intermediate form (MW = 41 kilodaltons). The latter is converted by
A Tanaka +2 more
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Hypertension, 2017 See related article, pp 119–128 Organisms tend to compensate for the need of a cellular function by increasing the amount or the size of the responsible cell type. Hypertrophy of all muscle types under increased workload is a prominent example. Also several hormone systems react by increasing the amount of hormone-producing cells, when the main ...
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Purification of Pig Renin [PDF]
Biochemical Journal, 1965 1. A new method of purification of renin is described. This method employs the following procedures: ethanol precipitation; saline extraction; precipitation of renin with 40% ammonium sulphate; precipitation of impurities with 3% ammonium sulphate at pH2.5; chromatography on DEAE-cellulose and CM-Sephadex; gel filtration on Sephadex G-100 (both normal ...
N Stone +5 more
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Serum Renin and Renin Substrate Levels in Scleroderma
Experimental Biology and Medicine, 1975 Scleroderma is a disease of mesenchymal tissues characterized by fibrosis and vascular changes which eventually lead to organ insufficiency. Two clinical forms have been recognized, localized and systemic scleroderma. The localized form only affects the skin and the lesions have a tendency to resolve spontaneously. Systemic scleroderma is a progressive,
Anne B. Gould, Raul Fleischmajer
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Inhibition of renin and the (pro)renin receptor system
Blood Pressure, 2012 Renin is the rate-limiting step of the renin-angiotensin system (RAS) and can induce hypertension and cardiovascular diseases (CVDs) through the over-activated renin-angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-Ang II type 1 receptor (AT(1)R) axis.
Robert D. Phillips +3 more
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Renin-Angiotensin System [PDF]
New England Journal of Medicine, 1975 ALTHOUGH the names of Tigerstedt and Bergman1 are associated with the first description in 1898 of renin extracted from the kidney, it may come as a surprise that when Tigerstedt, who was the senior worker in the partnership and the Professor of Physiology in the Karolinska Institute, Stockholm, died, there was no mention of renin in the various ...
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