Results 151 to 160 of about 172,199 (241)

Providing holistic care for patients with metabolic dysfunction‐associated steatotic liver disease/metabolic dysfunction‐associated steatohepatitis: Key aspects of clinical assessment and how to develop individualised care plans for surveillance and interventions

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD), characterised by hepatic steatosis and metabolic dysfunction (i.e., obesity, type 2 diabetes, dyslipidaemia, and hypertension), is affecting over 30% of the adult population worldwide.
Lanlan Chen, Paul Horn, Frank Tacke
wiley   +1 more source

Characteristics, therapeutic pathway and the economic burden of patients with drug‐resistant epilepsy: A real‐world analysis following the introduction of cenobamate in Italy

Epilepsia, EarlyView.
Abstract Objectives Drug‐resistant epilepsy (DRE) remains a major clinical challenge, affecting approximately one‐third of patients with epilepsy. Cenobamate, a novel antiseizure medication (ASM) approved in Italy in 2022, has shown promise in clinical trials. However, real‐world data on its use, especially economic evaluations, remain limited.
Valentina Perrone, Chiara Veronesi, Maria Cappuccilli, Margherita Andretta, Marcello Bacca, Antonietta Barbieri, Fausto Bartolini, Alessandro Brega, Maria Rosaria Cillo, Francesco Colasuonno, Stefania Dell'Orco, Fulvio Ferrante, Stefano Grego, Antonella Lavalle, Daniela Mancini, Maurizio Pastorello, Romina Pagliaro, Cataldo Procacci, Camilla Scandolara, Patrizia Schiavone, Loredana Ubertazzo, Paola Valpondi, Adriano Vercellone, Alberto Zucchi, Maria Ciappetta, Domenico Lucatelli, Andrea Cinti Luciani, Luca Degli Esposti   +27 more
wiley   +1 more source

Effects of CSF hormones and ionic composition on salt/water metabolism [PDF]

This collaborative agreement between Drs. Severs and Keil began in 1981, arising from a continuing interest in the issue of what, exactly, are the consequences of headward fluid shifts during manned spaceflight.
Keil, Lanny C., Severs, Walter B.
core   +1 more source

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

The FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Persistent headache (PH) after an aneurysmal subarachnoid hemorrhage (aSAH) and the influence of migraine history (MH) on its evolution and prognosis is poorly understood. Our study aims are to (1) determine the prevalence, characteristics, and prognostic factors of PH after aSAH; and (2) study the impact of personal MH ...
Laura Gómez‐Dabó, Víctor J. Gallardo, Daniel Campos‐Fernández, Marc Rodrigo‐Gisbert, Maider Iza‐Achutegui, Anna Sánchez, Fuat Arikan, Estevo Santamarina, Edoardo Caronna, Patricia Pozo‐Rosich   +9 more
wiley   +1 more source

Risks of dementia and stroke in patients with hypertension using telmisartan or other renin‑angiotensin system inhibitors [PDF]

Alzheimers Dement
Abstract INTRODUCTION The aim of this study was to investigate the cognitive and cerebrovascular outcomes of patients with hypertension (HTN) receiving various renin‐angiotensin system (RAS) inhibitors. METHODS We further categorized 39,665 patients with HTN receiving long‐term RAS inhibitor therapy into (1) telmisartan, (2) non‐telmisartan angiotensin
Liu C, Tsai M, Yang N, Chang T, Chen T, Wei Y.   +5 more
europepmc   +2 more sources

Loss of the liver circadian clock affects the expression of intrarenal renin-angiotensin system components. [PDF]

Sci Rep
Hassan SA, Stumpe M, Hui KY, Giraud MN, Albrecht U, Ripperger JA.   +5 more
europepmc   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Gut microbiota dysbiosis affects the local renin-angiotensin system to induce osteoporosis. [PDF]

Front Endocrinol (Lausanne)
Zhong K, Wang Y, Han P, Huang Z, Xie Z, Yu P, Liu H, Hu H, Tan M, Guo X.   +9 more
europepmc   +1 more source

Comorbidities and Healthcare Utilization in 4197 Patients With Prurigo Nodularis in Israel: A Cross‐Sectional Population‐Based Analysis

International Journal of Dermatology, EarlyView.
ABSTRACT Background Prurigo nodularis patients face a significant burden of comorbidities, necessitating a comprehensive approach to care. We aimed to explore the association between prurigo nodularis, its comorbid conditions, and healthcare usage patterns.
Yuliya Valdman‐Grinshpoun, Andrea Zaga, Arnon Dov Cohen, Yochai Schonmann, Tali Czarnowicki   +4 more
wiley   +1 more source