Results 21 to 30 of about 22,320,192 (343)

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

Circulation Research, 2020
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory ...
Mahmoud Gheblawi, Kaiming Wang, A. Viveiros, Quynh Nguyen, J. Zhong, A. Turner, M. Raizada, M. Grant, G. Oudit   +8 more
semanticscholar   +1 more source

Network and 16S rRNA Sequencing-Combined Approach Provides Insightal Evidence of Vitamin K2 for Salt-Sensitive Hypertension

Frontiers in Nutrition, 2021
Vitamin K2 (VK2), found to act to treat hypertension, has been widely used in the food and pharmaceutical industries nowadays. However, the potential targets and molecular mechanisms of VK2 for salt-sensitive hypertension have not been fully investigated.
Tian-hao Liu, Ming-hao Chen, Wan-qing Tu, Qiu-er Liang, Wen-cong Tao, Zhen Jin, Ya Xiao, Li-guo Chen   +7 more
doaj   +1 more source

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

New England Journal of Medicine, 2020
RAAS Inhibitors in Patients with Covid-19 The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain.
M. Vaduganathan, O. Vardeny, T. Michel, J. McMurray, M. Pfeffer, S. Solomon   +5 more
semanticscholar   +1 more source

Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension

Emerging Microbes and Infections, 2020
The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers
J. Meng, Guohui Xiao, Juanjuan Zhang, Xing He, M. Ou, Jing Bi, Rongqing Yang, Wencheng Di, Zhaoqin Wang, Zigang Li, Hong-yu Gao, Lei Liu, Guoliang Zhang   +12 more
semanticscholar   +1 more source

Renin-Angiotensin System in Pathogenesis of Atherosclerosis and Treatment of CVD

International Journal of Molecular Sciences, 2021
Atherosclerosis has complex pathogenesis, which involves at least three serious aspects: inflammation, lipid metabolism alterations, and endothelial injury.
A. Poznyak, D. Bharadwaj, Gauri Prasad, A. Grechko, M. Sazonova, A. Orekhov   +5 more
semanticscholar   +1 more source

Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure [PDF]

, 2020
Aims Activation of the renin-angiotensin-aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis.
Anker, Stefan D., Dickstein, Kenneth, Duarte, Kevin, Ferreira, Joao Pedro, Girerd, Nicolas, Kobayashi, Masatake, Lamiral, Zohra, Lang, Chim C., Metra, Macro, Ng, Leong L., Preud'homme, Gregoire, Rossignol, Patrick, Samani, Nilesh J., Stienen, Susan, ter Maaten, Jozine M., van Veldhuisen, Dirk J., Voors, Adriaan A., Zannad, Faiez   +17 more
core   +4 more sources

Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19

Cardiovascular Research, 2020
Systemic arterial hypertension (referred to as hypertension herein) is a major risk factor of mortality worldwide, and its importance is further emphasized in the context of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
R. Kreutz, E. Algharably, M. Azizi, P. Dobrowolski, T. Guzik, A. Januszewicz, A. Persu, A. Prejbisz, T. Riemer, Ji-Guang Wang, M. Burnier   +10 more
semanticscholar   +1 more source

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

New England Journal of Medicine, 2020
Background There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin ...
H. Reynolds, S. Adhikari, C. Pulgarin, A. Troxel, E. Iturrate, Stephen B. Johnson, A. Hausvater, J. Newman, J. Berger, S. Bangalore, S. Katz, G. Fishman, Dennis Kunichoff, Yu Chen, G. Ogedegbe, J. Hochman   +15 more
semanticscholar   +1 more source

Renin-Angiotensin System Blockers and the COVID-19 Pandemic

HYPERTENSION, 2020
During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19.
A. Danser, M. Epstein, D. Batlle
semanticscholar   +1 more source

What’s new in the renin-angiotensin system?

Cellular and Molecular Life Sciences (CMLS), 2004
.Cellular entry of enveloped viruses is often dependent on attachment proteins expressed on the host cell surface. Viral envelope proteins bind these receptors, and, in an incompletely understood process, facilitate fusion of the cellular and viral ...
Wenhui Li, M. J. Moore, N. Vasilieva, J. Sui, S. Wong, M. Berne, M. Somasundaran, J. Sullivan, K. Luzuriaga, T. Greenough, H. Choe, M. Farzan   +11 more
semanticscholar   +1 more source