Results 21 to 30 of about 22,692,331 (249)

Covid-19: the renin–angiotensin system imbalance hypothesis

Clinical science, 2020
The emergency of SARS-CoV-2 in China started a novel challenge to the scientific community. As the virus turns pandemic, scientists try to map the cellular mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 ...
Katharina Lanza, L. G. Perez, L. B. Costa, T. Cordeiro, Vitria A Palmeira, V. Ribeiro, A. C. Simões e Silva   +6 more
semanticscholar   +1 more source

Brain Renin–Angiotensin System at the Intersect of Physical and Cognitive Frailty

Frontiers in Neuroscience, 2020
The renin–angiotensin system (RAS) was initially considered to be part of the endocrine system regulating water and electrolyte balance, systemic vascular resistance, blood pressure, and cardiovascular homeostasis. It was later discovered that intracrine
Çağlar Coşarderelioğlu, Lolita S Nidadavolu, Claudene J. George, E. Oh, D. Bennett, J. Walston, P. Abadir   +6 more
semanticscholar   +1 more source

Additional file 1: of Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose reninâ angiotensin systems

, 2018
Table S1. The primer sequences used for quantitative polymerase chain reaction (qPCR). (DOC 43Â kb)
Hong-Ren Yu, Tain, You-Lin, Mao-Meng Tiao, Chih-Cheng Chen, Jiunn-Ming Sheen, I-Chun Lin, Shih-Wen Li, Ching-Chou Tsai, Lin, Yu-Ju, Hsieh, Kai-Sheng, Li-Tung Huang   +10 more
openaire   +1 more source

The renin-angiotensin system: going beyond the classical paradigms

American Journal of Physiology. Heart and Circulatory Physiology, 2019
Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the discovery of angiotensin-(1−7) [ANG-(1−7)] generation in vivo. Later, angiotensin-converting enzyme 2 (ACE2) was shown to be the main mediator of this reaction, and ...
R. Santos, G. Oudit, T. Verano-Braga, Giovanni Canta, U. Steckelings, M. Bader   +5 more
semanticscholar   +1 more source

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

Pharmacological Reviews, 2019
Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current therapies for hypertension and related cardiovascular diseases are still ...
Eric L. Barker, Lauren B. Arendse, A. H. J. Danser, M. Poglitsch, R. Touyz, Jr John C. Burnett, C. Llorens-Cortes, Mario R. Ehlers, E. Sturrock   +8 more
semanticscholar   +1 more source

Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics

Advanced Science, EarlyView.
A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li, Yaxin Zhu, Yumeng Yan, Jifeng Wang, Lili Niu, Xiang Ding, Mengmeng Zhang, Zhensheng Xie, Tanxi Cai, Xiaojing Guo, Jianming Luo, Peng An, Xiangqian Guo, Fuquan Yang   +13 more
wiley   +1 more source

Impact of Renin‐Angiotensin System Inhibitors on Renal Function During Temporary Ileostomy Period in Rectal Cancer Patients: A Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study explored the potential impact of renin–angiotensin system inhibitors (RASIs) on renal function during the ileostomy period in patients undergoing rectal cancer surgery. RASI use was associated with early postoperative renal impairment, and relatively slow recovery of renal function was observed until stoma closure.
Yusaku Shogen, Ryo Seishima, Masayoshi Monno, Satoru Morita, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa   +6 more
wiley   +1 more source

An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology

Journal of Cardiovascular Development and Disease, 2019
In its classical view, the renin angiotensin system (RAS) was defined as an endocrine system involved in blood pressure regulation and body electrolyte balance.
A. Nehme, Fouad A. Zouein, Z. Zayeri, K. Zibara   +3 more
semanticscholar   +1 more source

CURE ID: A Platform to Collect Real‐World Treatment Data for Drug Repurposing in Rare Genetic Disorders

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases collectively affect millions of Americans, but less than 5% have approved treatments, and new drug development remains limited. For such diseases, drug repurposing may be an effective strategy to find new treatment options. In the rare genetic disorder community, drugs are frequently prescribed off‐label.
Tahsin Farid, Maura R. Z. Ruzhnikov, Mili Duggal, Keyla C. Tumas, Shira Strongin, Eric Sid, Sarah R. Fuchs, Leonard Sacks, Dominique C. Pichard, Catherine Pilgrim‐Grayson, Ewy A. Mathé, Heather A. Stone   +11 more
wiley   +1 more source

Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions

Cancers, 2020
The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative ...
Maria Joana Pereira Catarata, R. Ribeiro, M. Oliveira, C. Robalo Cordeiro, R. Medeiros   +4 more
semanticscholar   +1 more source