Results 31 to 40 of about 22,320,192 (343)

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

New England Journal of Medicine, 2020
Background A potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting–enzyme (ACE) inhibitors and the risk of coronavirus disease 2019 (Covid-19) has not been well studied.
G. Mancia, F. Rea, M. Ludergnani, G. Apolone, G. Corrao   +4 more
semanticscholar   +1 more source

Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

Nature Reviews Nephrology, 2020
The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-
A. South, L. Tomlinson, Daniel L. Edmonston, S. Hiremath, M. Sparks   +4 more
semanticscholar   +1 more source

Hepcidin is potential regulator for renin activity

PLoS ONE, 2022
An association between genetic variants in the genes HFE, HJV, BMP4 and arterial hypertension has been shown earlier. Proteins encoded by these genes participate in the signalling routes leading eventually to the production of the peptide hormone ...
Jaakko Piesanen, Jarkko Valjakka, Sanna Niemelä, Marjut Borgenström, Seppo Nikkari, Vesa Hytönen, Juha Määttä, Tarja Kunnas   +7 more
doaj   +2 more sources

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Characteristics and Usefulness of the Direct Renin Inhibitor Aliskiren

Journal of Pharmacological Sciences, 2010
Since renin inhibition interferes with the first and rate-limiting steps in the renin–angiotensin system, the renin step is a very attractive target for lowering blood pressure and minimizing target-organ damage.
Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh   +6 more
doaj   +1 more source

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

Physiological Reviews, 2017
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body.
R. Santos, W. Sampaio, A. Alzamora, D. Motta-Santos, N. Alenina, M. Bader, M. Campagnole-Santos   +6 more
semanticscholar   +1 more source

COVID-19, Renin-Angiotensin System and Endothelial Dysfunction

Cells, 2020
The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused by SARS-CoV-2 virus, has posed a serious threat to global public health and caused worldwide social and economic breakdown.
Razie Amraei, N. Rahimi
semanticscholar   +1 more source

The renin–angiotensin system: a possible new target for depression

BMC Medicine, 2017
Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment ...
João Vian, Círia Pereira, Victor Chavarria, Cristiano Köhler, Brendon Stubbs, João Quevedo, Sung-Wan Kim, André F. Carvalho, Michael Berk, Brisa S. Fernandes   +9 more
doaj   +1 more source

Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations

Clinical Infectious Diseases, 2020
Mortality from coronavirus disease 2019 (COVID-19) is strongly associated with cardiovascular disease, diabetes, and hypertension. These disorders share underlying pathophysiology related to the renin-angiotensin system (RAS) that may be clinically ...
T. Hanff, M. O. Harhay, T. Brown, Jordana B. Cohen, Amir M. Mohareb   +4 more
semanticscholar   +1 more source

Pharmacological effects of raas blockade in ischemic nephropathy [PDF]

, 2016
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio, Cianci, Rosario, Coppolino, Giuseppe, Di Mario, Francesca, Farrah, Tariq E., Fuiano, Giorgio, Gigante, Antonietta, Rivoli, Laura, Rosato, Edoardo   +8 more
core   +1 more source

Cardio and neuro protection by renin angiotensin aldosterone system-focus inhibition angiotensin converting enzyme: A systematic review [PDF]

BIO Web of Conferences
One of the incidences of cardiovascular disease is stroke, which is a disease that occurs due to impaired brain function caused by damage to cerebral blood circulation.
Capritasari Rafiastiana, Akrom, Setianto Arif Budi   +2 more
doaj   +1 more source