Results 61 to 70 of about 22,544,156 (338)
Frontiers in Physiology, 2017 Large-conductance calcium-activated potassium channels (BK channels) belong to a family of Ca2+-sensitive voltage-dependent potassium channels and play a vital role in various physiological activities in the human body.
Zhen-Ye Zhang +2 more
doaj +1 more source
Arthritis Care &Research, Accepted Article.Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart +14 more
wiley +1 more source
Angiotensinergic innervation of rat and human mesenteric resistant blood vessels [PDF]
, 2007 In contrast to the current believe that angiotensin II (Ang II) only interacts with the sympathetic nervous system (SNS) as a circulating hormone, we document here the existence of an endogenous renin-angiotensin system (RAS) in the sympathetic coeliac ...
Eva Heiniger +4 more
core +1 more source
Advanced Science, EarlyView.Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng +7 more
wiley +1 more source
BiomedicinesCurrently, cardiovascular diseases are a major contributor to morbidity and mortality worldwide, having a significant negative impact on both the economy and public health.
Janette Alejandra Gamiño-Gutiérrez +10 more
doaj +1 more source
The renin-angiotensin system: going beyond the classical paradigms
American Journal of Physiology. Heart and Circulatory Physiology, 2019 Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the discovery of angiotensin-(1−7) [ANG-(1−7)] generation in vivo. Later, angiotensin-converting enzyme 2 (ACE2) was shown to be the main mediator of this reaction, and ...
R. Santos +5 more
semanticscholar +1 more source
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, EarlyView.This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers. [PDF]
, 2018 Background Our objective was to determine patterns of antihypertensive agent use by stage of chronic kidney disease (CKD) and to evaluate the association between different classes of antihypertensive agents with nonrenal outcomes, especially in advanced ...
Johansen, Kirsten L +4 more
core
Use Of Maximal Dosage Renin-Angiotensin-Aldosterone System Inhibitors In A Real Life Population Of Complicated Type 2 Diabetes – Contraindications And Opportunities [PDF]
, 2022 Christina M. Gant +6 more
openalex +1 more source
Cardiac Failure Review, 2019 Renin–angiotensin–aldosterone system inhibitors (RAASi) are known to improve outcomes in patients who have heart failure with reduced ejection fraction (HFrEF).
Giuseppe MC Rosano +3 more
doaj +1 more source