Results 171 to 180 of about 141,530 (342)

Capacities of laboratory diagnosis in the assessment of the activity of the renin-angiotensin-aldosterone system

open access: yesТерапевтический архив, 2010
The renin-angiotensin-aldosterone system (RAAS) plays a substantial role in the regulation of many cardiovascular parameters and renal function, including the maintenance of blood pressure and water-salt exchange. The paper describes the most intensively
M L Maksimov
doaj  

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

open access: yesExperimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu   +5 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

open access: yesExperimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó   +1 more
wiley   +1 more source

P3486Cytokine profile, renin-angiotensin aldosterone system and left ventricular remodelling in essential arterial hypertension comorbid with chronic obstructive pulmonary disease [PDF]

open access: bronze, 2018
И. С. Шпагин   +5 more
openalex   +1 more source

Early acclimatization to high altitude: Acid–base and fluid balance dynamics during the first 2 days at 3100 m

open access: yesExperimental Physiology, EarlyView.
Abstract Immediate responses to hypoxia at high altitude are hyperventilation and successive respiratory alkalosis. Alkalosis, in turn, can affect cerebrospinal fluid pH and ventilatory control. The kidneys compensate metabolically for respiratory alkalosis.
Elisabeth Skalla   +9 more
wiley   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand   +2 more
wiley   +1 more source

Management of Proteinuria in Dogs and Cats with Chronic Kidney Disease [PDF]

open access: yes, 2016
Atkins   +46 more
core   +2 more sources

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