SGLT2 inhibitors reduce skeletal muscle mass modestly in older adults with type 2 diabetes. Forest plot (a) and count our funnel plot (b) show a small but significant pooled reduction in muscle mass (SMD = −0.36, 95% CI [−0.56, −0.15]; I2 = 24.1%), with weight loss occurring predominantly through fat mass reduction.
Weena Joongpan +5 more
wiley +1 more source
Phenylephrine Vs. Norepinephrine on the Renin-Angiotensin-Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial. [PDF]
Chen J +14 more
europepmc +1 more source
Antihypertensive medications and risk of Alzheimer's disease: Evidence for specific medication use
Abstract BACKGROUND Hypertension is a modifiable risk factor for Alzheimer's disease (AD). Specific antihypertensive classes may lower/increase AD risk by affecting the renin–angiotensin–aldosterone system. METHODS We investigated AD risk in relation to antihypertensive medications in a population‐based study of 33,714 incident AD cases and 897,872 ...
Osvaldo J. Laurido‐Soto +6 more
wiley +1 more source
Quarterly injectable hormonal contraceptive does not increase the activity of the renin-angiotensin-aldosterone system in women without cardiovascular risk factors. [PDF]
de Oliveira AM +6 more
europepmc +1 more source
A remotely operated blood sampling and sedative administration device in freely moving pinnipeds
Abstract A remotely operated device for use with freely moving pinnipeds was designed and successfully developed for the collection of blood samples and the administration of sedatives via an indwelling, venous catheter. The performance of the sampler, called the ‘Mossquito’, was demonstrated on six wild caught, young‐of‐the‐year grey seals ...
Joanna L. Kershaw +10 more
wiley +1 more source
The Emerging Role of Aldosterone Synthase Inhibitors in Overcoming Renin-Angiotensin-Aldosterone System Therapy Limitations: A Narrative Review. [PDF]
Patel SK +4 more
europepmc +1 more source
ABSTRACT Aim Calcineurin inhibitors (CNI) such as tacrolimus (Tac) are the first‐line treatment to prevent transplant rejection. However, CNI have adverse effects on blood vessels and renal function, which may be linked to cellular senescence. Valsartan, a common angiotensin II type 1 receptor (AT1R) blocker, exhibits anti‐senescence properties.
Lingyan Fei +23 more
wiley +1 more source
Renin-Angiotensin-Aldosterone System Profiling in Horses Before and After Exercise. [PDF]
Holbrook T +6 more
europepmc +1 more source

