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[The renin-angiotensin-aldosterone system].
Deutsche medizinische Wochenschrift (1946), 1978"The present results indicate that there is a close relationship between the incretory function of the kidney, which is shown by the discharge of renin and similar materials, and the function of the adrenal cortex, especially the zona glomerulosa, which is the place of production of the sodium-retaining hormone aldosterone .
P, Vecsei, E, Hackenthal, D, Ganten
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Obesity and the renin– angiotensin–aldosterone system
Expert Review of Endocrinology & Metabolism, 2006The renin-angiotensin-aldosterone system (RAAS) is a key regulator of cardiovascular function. RAAS activity is upregulated in obesity despite concurrent renal sodium retention, which is a hallmark and principle determinant of obesity-associated hypertension.
Arya M, Sharma, Stefan, Engeli
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Renin-Angiotensin-Aldosterone System in Nephrotic Syndrome
American Journal of Kidney Diseases, 1984Previous studies on the renin-angiotensin-aldosterone system and fluid volumes in patients with nephrotic syndrome have not considered the nature of the underlying renal lesion. We compared plasma renin concentration (PRC), plasma aldosterone (PA), and plasma volume in three groups of patients: five nephrotic patients with minimal change disease on ...
T G, Hammond +5 more
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Adrenomedullin and the renin–angiotensin–aldosterone system
Regulatory Peptides, 2003Despite its positive inotropic effects and its propensity to stimulate the renin system, adrenomedullin (AM) is hypotensive as a result of dramatic reductions in peripheral resistance. Furthermore, it does not appear to increase aldosterone secretion in spite of often vigorous activation of circulating renin.
Christopher J, Charles +5 more
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The Renin-Angiotensin-Aldosterone System in Podocytes
Seminars in Nephrology, 2012The renin-angiotensin-aldosterone system (RAAS) plays a critical role in kidney function and its inhibition reduces proteinuria and preserves kidney function in patients with chronic kidney disease. Recent studies have shown that podocytes generate many components of the RAAS and they express receptors of RAAS, including angiotensin II ...
Dirk Oliver, Wennmann +2 more
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Renin-Angiotensin-Aldosterone System
Abstract Renin-angiotensin-aldosterone systems exist in various tissues throughout the body, including the kidneys, adrenal gland, cardiovascular system, and nervous system, where it may be involved in local regulation of vascular tone. Renin causes angiotensin to be cleaved into angiotensin I, which is then converted to angiotensin II ...Marwa El-Sabbahy, Karim Fikry
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Renin-Angiotensin-Aldosterone System in Hypertrophic Cardiomyopathy
Kardiologiia, 2014Keeping in mind an important role of renin-angiotensin aldosterone system (RAS) in developing of cardiac remodeling and fibrosis, genetic polymorphisms coding its components could have influence with clinical variants of the course. Biomarkers could appear predictors of adverse.
M V, Kozhevnikova +4 more
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Key developments in renin–angiotensin–aldosterone system inhibition
Nature Reviews Nephrology, 2012The renin-angiotensin-aldosterone system (RAAS) was initially thought to be fairly simple. However, this idea has been challenged following the development of RAAS blockers, including renin inhibitors, angiotensin-converting-enzyme (ACE) inhibitors, type 1 angiotensin II (AT(1))-receptor blockers and mineralocorticoid-receptor antagonists. Consequently,
Seva Pessoa, Bruno +5 more
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Hypertension and the Renin–Angiotensin–Aldosterone System
2018Hypertension is defined as a systolic blood pressure > 140 mmHg or a diastolic blood pressure > 90 mmHg. Renin is a key enzyme of the renin-angiotensin-aldosterone system (RAAS), cleaving angiotensinogen to angiotensin I and, thereby, having an impact on the synthesis rate of the effector hormone of the RAAS, angiotensin II. The RAAS is a hormone
Kaschina, Elena +2 more
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