Results 151 to 160 of about 221,319 (346)

SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper

open access: yesESC Heart Failure, EarlyView.
Abstract Background Sodium glucose co‐transporter 2 inhibitors (SGLT2i) and mineralocorticoid receptor antagonists (MRA) reduce heart failure (HF) events in patients with heart failure and mildly reduced or preserved ejection fraction (HFmr/pEF). The randomized comparison of SGLT2i/MRA combination versus SGLT2i or MRA alone requires further testing in ...
João Pedro Ferreira   +26 more
wiley   +1 more source

Renin as a target of direct pharmacological block in arterial hypertension

open access: yesТерапевтический архив, 2009
Renin is a basic component of renin-angiotensin-aldosteron system which contributes much to the activity of this system. Renin and its precursor prorenin can interact with prorenin receptors thus inducing hypertrophy and fibrogenesis in target tissues ...
Nikolay Alekseevich Mukhin   +3 more
doaj  

Optimization of renin‐angiotensin‐aldosterone inhibitor therapies for evidence‐based indications: a call to action from the cardio‐kidney community

open access: yes
ESC Heart Failure, EarlyView.
Roberto Pecoits‐Filho   +18 more
wiley   +1 more source

Dapagliflozin effect on functional mitral regurgitation and myocardial remodelling: The DEFORM trial

open access: yesESC Heart Failure, EarlyView.
Abstract Aims Functional mitral regurgitation (FMR) is associated with adverse outcomes in patients with heart failure, and current guideline‐directed medical therapy (GDMT) offers limited efficacy in managing FMR. This study aims to evaluate the therapeutic impact of the sodium‐glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in patients with ...
Zhuoshan Huang   +18 more
wiley   +1 more source

Right atrial remodelling and prognosis in patients with severe atrial functional tricuspid regurgitation

open access: yesESC Heart Failure, EarlyView.
Abstract Aims Atrial functional tricuspid regurgitation (AFTR) is increasingly recognized as a distinct cause of tricuspid regurgitation, yet data on outcomes and their determinants are limited. This study examines the prognostic role of right atrial (RA) remodelling in patients with severe AFTR.
Soongu Kwak   +8 more
wiley   +1 more source

Lower NT‐proBNP plasma concentrations in Pacific peoples with heart failure

open access: yesESC Heart Failure, EarlyView.
NT‐proBNP plasma concentrations were measured in participants of two NZ HF cohorts and were significantly lower in Pacific peoples and Māori compared with NZ Europeans. After accounting for age, sex, BMI, eGFR, LVEF and presence of AF, NT‐proBNP plasma concentrations remained significantly lower for Pacific peoples, but not for Māori.
Andree G. Pearson   +10 more
wiley   +1 more source

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