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On the Specificity of Renin [PDF]
Science, 1940 Fil: Braun Menéndez, Eduardo. Instituto de Fisiología. Facultad de Medicina.
Fasciolo, Juan C. +3 more
openaire +4 more sources
Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
New England Journal of Medicine, 2020 RAAS Inhibitors in Patients with Covid-19 The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain.
M. Vaduganathan +5 more
semanticscholar +1 more source
Journal of the Renin-Angiotensin-Aldosterone System, 2005 Renin is an aspartic protease that consists of 2 homologous lobes. The cleft in between contains the active site with 2 catalytic aspartic residues.1 Unlike other aspartic proteases such as pepsin or cathepsin D, renin is monospecific and only cleaves angiotensinogen, to generate angiotensin (Ang) I.
Friedrich C. Luft +9 more
openaire +8 more sources
Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19
New England Journal of Medicine, 2020 Background There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin ...
H. Reynolds +15 more
semanticscholar +1 more source
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System
Circulation Research, 2020 ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory ...
Mahmoud Gheblawi +8 more
semanticscholar +1 more source
Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19
New England Journal of Medicine, 2020 Background A potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting–enzyme (ACE) inhibitors and the risk of coronavirus disease 2019 (Covid-19) has not been well studied.
G. Mancia +4 more
semanticscholar +1 more source
Renin-Angiotensin System Blockers and the COVID-19 Pandemic
HYPERTENSION, 2020 During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19.
A. Danser, M. Epstein, D. Batlle
semanticscholar +1 more source
American Journal of Respiratory and Critical Care Medicine, 2020 Rationale: Exogenous angiotensin II increases mean arterial pressure in patients with catecholamine-resistant vasodilatory shock (CRVS). We hypothesized that renin concentrations may identify patients most likely to benefit from such therapy. Objectives:
R. Bellomo +13 more
semanticscholar +1 more source
What’s new in the renin-angiotensin system?
Cellular and Molecular Life Sciences (CMLS), 2004 .Cellular entry of enveloped viruses is often dependent on attachment proteins expressed on the host cell surface. Viral envelope proteins bind these receptors, and, in an incompletely understood process, facilitate fusion of the cellular and viral ...
Wenhui Li +11 more
semanticscholar +1 more source
Counter-regulatory renin–angiotensin system in cardiovascular disease
Nature Reviews Cardiology, 2019 The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I and II — initially thought to be biologically inactive — have key roles in cardiovascular ...
María Paz Ocaranza +6 more
semanticscholar +1 more source