Results 21 to 30 of about 141,217 (309)
Food & Nutrition Research, 2015 Background: Cod muscle has a balanced protein profile that contains potentially bioactive amino acid sequences. However, there is limited information on release of these peptides from the parent proteins and their ability to modulate mammalian blood ...
Abraham T. Girgih +5 more
doaj +1 more source
Arterial Hypertension, 2021 Kidneys produce a number of substances that affect intrarenal blood circulation; however, the key system that regulates blood flow in both general and local circulation (including the renal circulation) is the renin-angiotensinaldosterone system (RAAS ...
Natalia Butt-Hussaim, Jacek Manitius
doaj +1 more source
Advanced Science, EarlyView.A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li +13 more
wiley +1 more source
Diagnosis and management of primary aldosteronism
Archives of Endocrinology and MetabolismPrimary aldosteronism (PA) is the most common form of secondary hypertension (HTN), with an estimated prevalence of 4% of hypertensive patients in primary care and around 10% of referred patients. Patients with PA have higher cardiovascular morbidity and
Leticia A. P. Vilela, Madson Q. Almeida
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Blood Pressure, 2023 Purpose Primary aldosteronism (PA), characterised by low-renin hypertension, confers a high cardiovascular risk and is the most common cause of secondary hypertension, with an increased prevalence in patients with treatment-resistant hypertension ...
Christian Beger +6 more
doaj +1 more source
Influence of Polymorphism of Vitamin D Receptor (Fok I) on Hypertension [PDF]
Brazilian Archives of Biology and Technology, 2020 Evidence suggests that polymorphisms in the gene encoding a vitamin D receptor might affect blood pressure. The objective of this systematic review was to investigate the association between hypertension and vitamin D receptor (Fok I) gene polymorphism ...
Ivone Freires de Oliveira Costa Nunes +4 more
doaj +2 more sources
Annals of Gastroenterological Surgery, EarlyView.This retrospective study explored the potential impact of renin–angiotensin system inhibitors (RASIs) on renal function during the ileostomy period in patients undergoing rectal cancer surgery. RASI use was associated with early postoperative renal impairment, and relatively slow recovery of renal function was observed until stoma closure.
Yusaku Shogen +6 more
wiley +1 more source
Blood Pressure, 2020 Purpose: The renin-angiotensin-aldosterone system (RAAS) plays an important role in maintaining hemodynamic homeostasis. Ethnic disparities exist regarding RAAS activity due to sympathetic activity and sodium-water retention, however the implications ...
Lebo F. Gafane-Matemane +3 more
doaj +1 more source
Latent Adrenal Insufficiency: From Concept to Diagnosis
Frontiers in Endocrinology, 2021 Primary adrenal insufficiency (PAI) is a rare disease and potentially fatal if unrecognized. It is characterized by destruction of the adrenal cortex, most frequently of autoimmune origin, resulting in glucocorticoid, mineralocorticoid, and adrenal ...
Nada Younes +2 more
doaj +1 more source
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Rare diseases collectively affect millions of Americans, but less than 5% have approved treatments, and new drug development remains limited. For such diseases, drug repurposing may be an effective strategy to find new treatment options. In the rare genetic disorder community, drugs are frequently prescribed off‐label.
Tahsin Farid +11 more
wiley +1 more source