Results 41 to 50 of about 3,459,561 (335)

Effect of SGLT2 inhibitors on body composition, fluid status and renin–angiotensin–aldosterone system in type 2 diabetes: a prospective study using bioimpedance spectroscopy

Cardiovascular Diabetology, 2019
BackgroundSGLT2-inhibitors are potent antihyperglycemic drugs for patients with type 2 diabetes and have been shown to reduce body weight. However, it is unclear which body compartments are reduced and to what extent.MethodsIn this longitudinal ...
A. Schork, Janine Saynisch, A. Vosseler, B. Jaghutriz, N. Heyne, A. Peter, H. Häring, N. Stefan, A. Fritsche, F. Artunc   +9 more
semanticscholar   +1 more source

Bradykinin is a mediator of anaphylactoid reactions during hemodialysis with AN69 membranes [PDF]

, 1994
Bradykinin is a mediator of anaphylactoid reactions during hemodialysis with AN69 membranes. Anaphylactoid reactions (AR) are the most feared complications of hemodialysis.
Verresen, Luc, Lemke, Horst-Dieter, Vanrenterghem, Yves, Fink, Edwin   +3 more
core   +1 more source

Renin-Inhibitoren – Von 'transition-state' Analogen und Peptidmimetika zu blutdrucksenkenden Wirkstoffen

CHIMIA, 1991
During the last 10 years, a great worldwide effort was devoted towards the discovery of orally active renin inhibitors as blood-pressure-lowering drugs.
Beat Weidmann
doaj   +2 more sources

Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct

Frontiers in Physiology, 2020
In the kidney, the stimulation of renin production by the collecting duct (CD-renin) contributes to the development of hypertension. The CD is a major nephron segment for the synthesis of nitric oxide (NO), and low NO bioavailability in the renal medulla
Andrew C. Curnow, Sabrina R. Gonsalez, Sabrina R. Gonsalez, Venkateswara R. Gogulamudi, Bruna Visniauskas, Eric E. Simon, Alexis A. Gonzalez, Dewan S. A. Majid, Dewan S. A. Majid, Lucienne S. Lara, Minolfa C. Prieto, Minolfa C. Prieto   +11 more
doaj   +1 more source

The potential therapeutic use of renin–angiotensin system inhibitors in the treatment of inflammatory diseases

Journal of Cellular Physiology, 2018
Inflammation is a normal part of the immune response to injury or infection but its dysregulation promotes the development of inflammatory diseases, which cause considerable human suffering.
R. Ranjbar, Mojtaba Shafiee, Amirreza Hesari, G. Ferns, F. Ghasemi, A. Avan   +5 more
semanticscholar   +1 more source

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

New England Journal of Medicine, 2020
Background A potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting–enzyme (ACE) inhibitors and the risk of coronavirus disease 2019 (Covid-19) has not been well studied.
G. Mancia, F. Rea, M. Ludergnani, G. Apolone, G. Corrao   +4 more
semanticscholar   +1 more source

Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney

, 1993
Using isolated rat kidneys perfused at controlled pressure, we examined a potential role of endothelium-derived relaxing factor (EDRF) in the pressure control of renin secretion.
Kurtz, Armin, Scholz, H., A Kurtz, Armin Kurtz, Holger Scholz, H Scholz   +5 more
core   +1 more source

The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies

Mediators of Inflammation, 2009
Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. The regulation of arterial blood pressure was considered from its first description of the main mechanism involved.
Fabrizio Montecucco, Aldo Pende, François Mach   +2 more
doaj   +1 more source

Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis?

BMC Nephrology, 2012
Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Fernandez-Fernandez Beatriz, Ortiz Alberto, Gomez-Guerrero Carmen, Barat Antonio, Martín-Cleary Catalina, Egido Jesús   +5 more
doaj   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source