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Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro [PDF]
, 1992 To find out whether calmodulin activity could be a common denominator for the cellular control of renin secretion and synthesis, we have examined the effects of calmodulin antagonists on the secretion and the synthesis of renin in primary cultures of ...
Kurtz, Armin +7 more
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The Use of Renin-Angiotensin System Blockades Among Patients with Chronic Kidney Disease
Advanced Medical Journal, 2023 Background and objectives: Hypertension is common in adult patients with chronic kidney disease with a prevalence that depends on the stage and etiology of chronic kidney disease and has been reported to range from 60-90%.
Majeed Hassan Shekhany
doaj +1 more source
Journal of Pharmacological Sciences, 2010 Since renin inhibition interferes with the first and rate-limiting steps in the renin–angiotensin system, the renin step is a very attractive target for lowering blood pressure and minimizing target-organ damage.
Atsuhiro Ichihara +6 more
doaj +1 more source
JCI Insight, 2021 Inhibitors of the renin-angiotensin system (RAS) are widely used to treat hypertension. Using mice harboring fluorescent cell lineage tracers, single-cell RNA-Seq, and long-term inhibition of RAS in both mice and humans, we found that deletion of renin ...
Hirofumi Watanabe +9 more
doaj +1 more source
Кардиоваскулярная терапия и профилактика, 2011 In the 1970s, pharmacological therapy interrupting the renin-angiotensin system was considered beneficial for patients with high-renin hypertension. Angiotensin-converting enzyme (ACE) inhibitors proved to be effective not only in patients with high ...
C. Napoli
doaj +1 more source
Aliskiren: An orally active renin inhibitor
Journal of Pharmacy and Bioallied Sciences, 2011 Renin inhibitors are antihypertensive drugs that block the first step in the renin-angiotensin system. Their mechanism of action differs from that of the angiotensin-converting enzyme inhibitors and angiotensin-receptor antagonists, but like these drugs,
Pranay Wal +3 more
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Investigation renin inhibitor activity from flavonoids derivates by in silico study
Journal of Advanced Pharmaceutical Technology & Research, 2023 Flavonoids have various pharmacological activities, such as antihypertensive, anticancer, and and antidiabetic effects. Several studies have shown that luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin have ...
Aprilita Rina Yanti Eff +4 more
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Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease.
New England Journal of Medicine, 2022 BACKGROUND Renin-angiotensin system (RAS) inhibitors - including angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) - slow the progression of mild or moderate chronic kidney disease.
S. Bhandari +7 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2019 The renin-angiotensin system (RAS) plays an important role in regulating body fluids and blood pressure. However, inappropriate activation of the RAS contributes to the pathogenesis of cardiovascular and renal diseases.
Tuba M Ansary, D. Nakano, A. Nishiyama
semanticscholar +1 more source
Case Reports in Nephrology, 2020 The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna +7 more
doaj +1 more source