Results 11 to 20 of about 58,938 (145)
Кардиоваскулярная терапия и профилактика, 2011 In the 1970s, pharmacological therapy interrupting the renin-angiotensin system was considered beneficial for patients with high-renin hypertension. Angiotensin-converting enzyme (ACE) inhibitors proved to be effective not only in patients with high ...
C. Napoli
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JCI Insight, 2021 Inhibitors of the renin-angiotensin system (RAS) are widely used to treat hypertension. Using mice harboring fluorescent cell lineage tracers, single-cell RNA-Seq, and long-term inhibition of RAS in both mice and humans, we found that deletion of renin ...
Hirofumi Watanabe +9 more
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Aliskiren: An orally active renin inhibitor
Journal of Pharmacy and Bioallied Sciences, 2011 Renin inhibitors are antihypertensive drugs that block the first step in the renin-angiotensin system. Their mechanism of action differs from that of the angiotensin-converting enzyme inhibitors and angiotensin-receptor antagonists, but like these drugs,
Pranay Wal +3 more
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Investigation renin inhibitor activity from flavonoids derivates by in silico study
Journal of Advanced Pharmaceutical Technology & Research, 2023 Flavonoids have various pharmacological activities, such as antihypertensive, anticancer, and and antidiabetic effects. Several studies have shown that luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin have ...
Aprilita Rina Yanti Eff +4 more
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Renin–angiotensin–aldosterone pathway modulators in chronic kidney disease: A comparative review
Frontiers in Pharmacology, 2023 Chronic kidney disease presents a health challenge that has a complex underlying pathophysiology, both acquired and inherited. The pharmacotherapeutic treatment options available today lower the progression of the disease and improve the quality of life ...
Saeed Alshahrani
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Case Reports in Nephrology, 2020 The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna +7 more
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CHIMIA, 1991 During the last 10 years, a great worldwide effort was devoted towards the discovery of orally active renin inhibitors as blood-pressure-lowering drugs.
Beat Weidmann
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Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct
Frontiers in Physiology, 2020 In the kidney, the stimulation of renin production by the collecting duct (CD-renin) contributes to the development of hypertension. The CD is a major nephron segment for the synthesis of nitric oxide (NO), and low NO bioavailability in the renal medulla
Andrew C. Curnow +11 more
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Mediators of Inflammation, 2009 Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. The regulation of arterial blood pressure was considered from its first description of the main mechanism involved.
Fabrizio Montecucco +2 more
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Cardiac Failure Review, 2019 Renin–angiotensin–aldosterone system inhibitors (RAASi) are known to improve outcomes in patients who have heart failure with reduced ejection fraction (HFrEF).
Giuseppe MC Rosano +3 more
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