Results 21 to 30 of about 756,250 (282)

Investigation renin inhibitor activity from flavonoids derivates by in silico study

Journal of Advanced Pharmaceutical Technology & Research, 2023
Flavonoids have various pharmacological activities, such as antihypertensive, anticancer, and and antidiabetic effects. Several studies have shown that luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin have ...
Aprilita Rina Yanti Eff, Ivana Theresia Yenhart, Yonatan Eden, Sri Teguh Rahayu, Putu Gita Mayawidyaswari Mahayasih   +4 more
doaj   +1 more source

Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells [PDF]

, 1991
Utilizing cocultures of mouse renal juxtaglomerular cells with bovine microvascular endothelial cells, we have examined whether endothelial cells exert direct influence on renin secretion from renal juxtaglomerular cells.
Kaissling, Brigitte, Kurtz, Armin, Baier, Wolfgang, W Baier, R Busse, A Kurtz, Busse, Rudi, B Kaissling   +7 more
core   +1 more source

Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension

, 2020
The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers
Juanjuan Zhang (432819), Wencheng Di (4229878), Zhaoqin Wang (1481548), Juan Meng (495487), Guoliang Zhang (151556), Min Ou (1540624), Lei Liu (5074), Xing He (614068), Jing Bi (1332591), Hong Gao (68166), Guohui Xiao (3529880), Zigang Li (606370), Rongqing Yang (169625)   +12 more
core   +1 more source

Renin–angiotensin–aldosterone pathway modulators in chronic kidney disease: A comparative review

Frontiers in Pharmacology, 2023
Chronic kidney disease presents a health challenge that has a complex underlying pathophysiology, both acquired and inherited. The pharmacotherapeutic treatment options available today lower the progression of the disease and improve the quality of life ...
Saeed Alshahrani
doaj   +1 more source

Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

Case Reports in Nephrology, 2020
The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna, Venu Madhav Konala, Subhasish Bose, Sasmit Roy, Bhaskar Reddy Madhira, Vijay Gayam, Srikanth Naramala, Sreedhar Adapa   +7 more
doaj   +1 more source

Renin-Inhibitoren – Von 'transition-state' Analogen und Peptidmimetika zu blutdrucksenkenden Wirkstoffen

CHIMIA, 1991
During the last 10 years, a great worldwide effort was devoted towards the discovery of orally active renin inhibitors as blood-pressure-lowering drugs.
Beat Weidmann
doaj   +2 more sources

Calcitonin gene-related peptide is a stimulator of renin secretion [PDF]

, 1988
Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [
Fischer, J. A., R Muff, Gnädinger, M. P., Uehlinger, D. E., Weidmann, P., A Kurtz, M P Gnädinger, W Born, Muff, R., J M Lundberg, T Hökfelt, P Weidmann, Kurtz, Armin, Lundberg, J. M., D E Uehlinger, Born, W., Millberg, B. I., Hökfelt, T., J A Fischer, B I Millberg, Weidmann P, Fischer JA, Millberg BI, Born W, Hökfelt T, Kurtz A, Uehlinger DE, Gnädinger MP, Lundberg JM, Muff R   +29 more
core   +1 more source

Stimulation of renin secretion by potassium-channel activation with cromakalim [PDF]

, 1989
The cardiovascular and endocrine profile of cromakalim has been studied in 8 healthy men (age 25 +/- 2 years: means SEM) and its influence on renin release from cultured rat juxtaglomerular cells in vitro has also been examined.
Kurtz, Armin, Lehner, P., Shaw, S. G., Weidmann, P., Ferrier, C. P., Pusterla, C., Saxenhofer, H., Shaw SG, Ferrier CP, Weidmann P, Saxenhofer H, Pusterla C, Kurtz A, Lehner P   +13 more
core   +1 more source

Changes in the use of renin-angiotensin system inhibitors after 3 months of index date.

, 2023
Changes in the use of renin-angiotensin system inhibitors after 3 months of index date.
Chih-Wei Chen (403470), Chun-Yao Huang (143386), Yi-Cheng Lin (1449802), Li-Nien Chien (638237), Wan-Ting Chen (1630204), Chun-Wei Chang (380018)   +5 more
core   +1 more source

Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct

Frontiers in Physiology, 2020
In the kidney, the stimulation of renin production by the collecting duct (CD-renin) contributes to the development of hypertension. The CD is a major nephron segment for the synthesis of nitric oxide (NO), and low NO bioavailability in the renal medulla
Andrew C. Curnow, Sabrina R. Gonsalez, Sabrina R. Gonsalez, Venkateswara R. Gogulamudi, Bruna Visniauskas, Eric E. Simon, Alexis A. Gonzalez, Dewan S. A. Majid, Dewan S. A. Majid, Lucienne S. Lara, Minolfa C. Prieto, Minolfa C. Prieto   +11 more
doaj   +1 more source