Results 21 to 30 of about 3,459,561 (335)
Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists on Renin-Angiotensin-Aldosterone System
Frontiers in Endocrinology, 2021 Sodium-glucose cotransporters inhibitors (SGLT2-i) and GLP-1 receptor agonists (GLP1-RA) are glucose-lowering drugs that are proved to reduce the cardiovascular (CV) risk in type 2 diabetes mellitus (T2DM).
S. Puglisi +6 more
semanticscholar +1 more source
Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
New England Journal of Medicine, 2020 RAAS Inhibitors in Patients with Covid-19 The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain.
M. Vaduganathan +5 more
semanticscholar +1 more source
Therapeutic Implications of Renin–Angiotensin System Modulators in Alzheimer’s Dementia
Pharmaceutics, 2023 The Renin–Angiotensin System (RAS) has attracted considerable interest beyond its traditional cardiovascular role due to emerging data indicating its potential involvement in neurodegenerative diseases, including Alzheimer’s dementia (AD).
Daniela-Carmen Ababei +8 more
doaj +1 more source
Advanced Medical Journal, 2023 Background and objectives: Hypertension is an important cardiovascular disease that carries a high rate of mortality and morbidity if not controlled. Significant complications of untreated hypertension include vascular atherosclerosis, chronic kidney ...
Mohammed Hasan Almeshhadani +3 more
doaj +1 more source
Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19
New England Journal of Medicine, 2020 Background There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin ...
H. Reynolds +15 more
semanticscholar +1 more source
European Heart Journal, 2020 Aims The current pandemic coronavirus SARS-CoV-2 infects a wide age group but predominantly elderly individuals, especially men and those with cardiovascular disease. Recent reports suggest an association with use of renin–angiotensin–aldosterone system (
I. Sama +17 more
semanticscholar +1 more source
The Lancet, 2020 Summary Background Concerns have been raised about the possibility that inhibitors of the renin–angiotensin–aldosterone system (RAAS) could predispose individuals to severe COVID-19; however, epidemiological evidence is lacking.
F. D. de Abajo +31 more
semanticscholar +1 more source
Development of a novel murine heart failure model overexpressing human renin and angiotensinogen
FEBS Open Bio, 2020 Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the potency ...
Tomoya Hara +6 more
doaj +1 more source
The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC
The Journal of Clinical Hypertension, 2022 Although neurohormones and Renin‐Angiotensin‐Aldosterone‐System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS‐blockers and different degrees of ...
Babak Yazdani +9 more
doaj +1 more source
Inhibitors of the Renin–Angiotensin–Aldosterone System and Covid-19
New England Journal of Medicine, 2020 RAAS Inhibitors and Covid-19 The editors comment on three Journal articles that provide observational data about whether ACE inhibitors and ARBs are harmful in the context of the Covid-19 epidemic....
J. Jarcho +4 more
semanticscholar +1 more source