Results 91 to 100 of about 432,839 (343)

Kv7-channel Blockage Reduces Liver Ischemia-reperfusion Injury in Mice [PDF]

, 2023
Johanna Ollesky, Marcella Steffani, Carolin Mogler, Fabian Stöcker, Volker Aßfalg, Helmut Frieß, Norbert Hüser, Daniel Hartmann   +7 more
openalex   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

The Effect of Hepcidin on Cardiac Ischemia-Reperfusion Injury

Journal of Investigative Surgery, 2020
Background/aim: Hepcidin is the main hormone in the regulation of iron metabolism which is also released from the heart. The aim of our study was to investigate the effects of hepcidin on the cardiac ischemia-reperfusion injury. Materials and methods: In
Atilla Bayraktar, Deniz Erbaş, Saadet Özen Akarca Dizakar, Tayfun Göktaş, Suna Ömeroğlu, Eser Öz Oyar   +5 more
doaj   +1 more source

Ischaemia-reperfusion injury

Journal of British Surgery, 1994
Abstract Ischaemia-reperfusion injury is a complex phenomenon often encountered in surgical practice. The consequences of such injury are local and remote tissue destruction, and sometimes death. Several different processes have been implicated. This review discusses the pathology of such injury, the mechanisms of free radical production,
openaire   +2 more sources

Investigating Mitochondrial Viscosity in Ferroptosis‐Mediated Drug‐Induced Liver Injury using a Double‐Targeted Strategy

Advanced Science, EarlyView.
Utilizing a mitochondrial double‐targeted strategy, a novel near‐infrared fluorescent probe (FTZ‐2) is established for monitoring viscosity variations in ferroptosis‐mediated drug‐induced liver injury. In summary, this work provided a practical strategy for the early diagnosis and evaluation of liver injury.
Yongqing Zhou, Yan Wang, Bing Huang, Hosoowi Lee, Mei Yan, Juyoung Yoon   +5 more
wiley   +1 more source

Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Personalized blood pressure (BP) management for patients with acute ischemic stroke after successful endovascular thrombectomy lacks evidence.
Zhe Zhang, Yuehua Pu, Lei Yu, Haiwei Bai, Wanying Duan, Xin Liu, Ximing Nie, Zhixuan Wen, Lina Zheng, Xiao Hu, Xinyi Leng, Yuesong Pan, Nils H. Petersen, Liping Liu   +13 more
doaj   +1 more source

Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies.

Journal of Biomedical Research, 2019
Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of increasing significance due to increased use of expanded criteria livers for transplantation.
S. Rampes, D. Ma
semanticscholar   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury [PDF]

, 2021
Min Xie, Geoffrey W. Cho, Yongli Kong, Dan L. Li, Francisco Altamirano, Xiang Luo, Cyndi R. Morales, Nan Jiang, Gabriele G. Schiattarella, Herman I. May, Jessica Medina, John M. Shelton, Anwarul Ferdous, Thomas G. Gillette, Joseph A. Hill   +14 more
openalex   +1 more source