Results 111 to 120 of about 213,084 (256)

Plateforme Répertoire des écritures numériques

Nouveaux Cahiers de Marge
Plateforme Répertoire des écritures numériques
doaj   +1 more source

The Steroidal Profile Modulates Adaptive Immune Response and Prognosis in Adrenocortical Carcinoma: Analysis of TCR and BCR Repertoires. [PDF]

Cancer Med
de Souza Resende JS, Giner IS, Muzzi JCD, Barbuto JAM, Lalli E, Castro MAA, de Figueiredo BC.   +6 more
europepmc   +1 more source

Rare‐Earth Mediated Engineering in ZnSe@ZnS:Eu3+ to Simultaneously Achieve Structural Modulation and Atomic Eu Doping Sites for X‐Ray Imaging

Advanced Science, EarlyView.
A dual hard‐base anchoring strategy was developed to synthesize ZnSe@ZnS:Eu3+ quantum dots, leveraging fluoride‐oleylamine interactions to create surface atomic Eu doping sites. By precisely tuning temperature, Eu3+ concentration, and fluoride levels, we obtain morphologies ranging from tip growth to coupled flower‐like structures.
Jicun Ma, Chenhao Yang, Jiada Fan, Haorong Jiao, Jiawang Liu, Jialiang Xu, Hui Cai, Yinghui Wang, Boyuan Shen, Jiabin Cui   +9 more
wiley   +1 more source

Early Evolution of the Prokaryotic Transcription Factor Repertoire. [PDF]

Genome Biol Evol
Singh IR, Dubey A, Seshasayee ASN.
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

High-throughput profiling of the T cell receptor delta CDR3 repertoire reveals species-specific patterns in cattle (Bos taurus) and water buffalo (Bubalus bubalis). [PDF]

Front Immunol
Zhang Y, Wu F, Ma L, Yao X, Li J.
europepmc   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source

Physicochemical convergence in antibody CDR3-VH repertoires recognizing phosphorothioate-modified oligonucleotides backbone. [PDF]

Front Immunol
Galasso R, Coppolino F, Berbiglia A, Privitera GF, Famà A, De Gaetano GV, Lentini G, Beninati C.   +7 more
europepmc   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Correction: Porcine B cell receptor repertoire uncovers balanced recognition of antigenic structures on serotype Asia1 foot-and-mouth disease virus. [PDF]

PLoS Pathog
PLOS One Staff.
europepmc   +1 more source