Results 111 to 120 of about 757,066 (352)
Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, EarlyView.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source
Advanced Science, EarlyView.DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang +11 more
wiley +1 more source
Emotion Regulation Flexibility: Gender Differences in Context Sensitivity and Repertoire
Frontiers in Psychology, 2019 Emotion regulation (ER) has been conceptualized as processes through which individuals modulate their emotions consciously and non-consciously to respond appropriately to environmental demands.
K. Elise Goubet, Evangelia G. Chrysikou
doaj +1 more source
Negotiating the in-between : how two foreigners living in rural Japan narrated changes in their identities : a thesis presented in partial fulfilment of the requirements for the degree of Masters in Education (Guidance Studies), Massey University, Palmerston North, New Zealand [PDF]
, 2009 This thesis used narrative inquiry to find out how two foreigners, who had resided in rural Japan for a long period of time, narrated reflectively how they had changed as a result of their cross-cultural transitions. This thesis came about through my own
Lankshear, Andrew
core
Advanced Science, EarlyView.Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He +10 more
wiley +1 more source
Slow feature analysis yields a rich repertoire of complex cell properties [PDF]
, 2003 In this study, we investigate temporal slowness as a learning principle for receptive fields using slow feature analysis, a new algorithm to determine functions that extract slowly varying signals from the input data.
Berkes, Pietro, Wiskott, Laurenz
core
Correlations in the T Cell Response to Altered Peptide Ligands
, 2004 The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases.
Arstila +26 more
core +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Optimizing the breadth of SARS-CoV-2-neutralizing antibodies in vivo and in silico
Human Vaccines & ImmunotherapeuticsSince the emergence of SARS-CoV-2, the ongoing arms race between mutating viruses and human antibodies has revealed several novel strategies by which antibodies adapt to viral escape. While SARS-CoV-2 viruses exhibit high variability in epitopes targeted
Daisuke Kuroda +3 more
doaj +1 more source