Results 131 to 140 of about 169,378 (259)

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.

Proceedings of the National Academy of Sciences of the United States of America, 2000
A. Ozinsky, D. Underhill, J. Fontenot, A. Hajjar, Kelly D. Smith, Christopher B Wilson, Lea Schroeder, A. Aderem   +7 more
semanticscholar   +1 more source

Mucosal or systemic microbiota exposures shape the B cell repertoire

Nature, 2020
Hai Li, Julien P. Limenitakis, Victor Greiff, B. Yilmaz, Olivier P. Schären, Camilla Urbaniak, Mirjam Zünd, Melissa A. E. Lawson, Ian D Young, Sandra Rupp, Mathias Heikenwälder, K. McCoy, S. Hapfelmeier, S. Ganal-Vonarburg, A. Macpherson   +14 more
semanticscholar   +1 more source

A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis

Advanced Science, EarlyView.
This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen, Yuchen Li, Liang Zhang, Xiaosong Ma, Chenyin Peng, Chunting Yuan, Yu Wu, Kaiyu Zhao, Sheng Zhao, Jiazhuo Guo, Run Li, Ziqian Yan, Shule Ren, Yige Han, Xin Lin, Xinyue Li, Ming Li, Pingfang Yang, Shiyong Song   +18 more
wiley   +1 more source

Intelligent recommendation algorithm for piano tracks based on the CNN model

Nonlinear Engineering
In order to improve the effect of intelligent recommendation of piano repertoire, this article combines the convolutional neural network (CNN) model to perform intelligent analysis of piano repertoire and combines personal preference for piano repertoire
Zhang Qi
doaj   +1 more source

Cell-free gene expression: an expanded repertoire of applications

Nature reviews genetics, 2019
A. Silverman, Ashty S. Karim, M. Jewett
semanticscholar   +1 more source

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

Nature Medicine, 2018
W. Scheper, S. Kelderman, Lorenzo F. Fanchi, C. Linnemann, G. Bendle, M. A. de Rooij, C. Hirt, R. Mezzadra, M. Slagter, K. Dijkstra, R. J. Kluin, P. Snaebjornsson, K. Milne, B. Nelson, H. Zijlmans, G. Kenter, E. Voest, J. Haanen, T. Schumacher   +18 more
semanticscholar   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source