Results 141 to 150 of about 213,084 (256)

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Preexisting TCR Clones Drive Major Pathologic Responses in Patients with HNSCC Treated with Dual Immune Checkpoint Inhibitors. [PDF]

Clin Cancer Res
Ge H, Li H, Kulkarni A, Chen Z, Upadhyay P, Ferris RL, Wang JH.   +6 more
europepmc   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

The Abundance of α-Chain-Centric TCRs in the Mouse Repertoire of Primarily Activated Effectors and Reactivated Memory T Cells. [PDF]

Comput Struct Biotechnol J
Kalinina A, Kubekina M, Persiyantseva N, Bruter A, Khromykh L, Kazansky D.   +5 more
europepmc   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Longitudinal TCR repertoire profiling predicts refractory cytomegalovirus reactivation after haploidentical hematopoietic stem cell transplantation. [PDF]

Virol J
Yuan H, Liu L, Chen G, Xu J, Zhang K, Yang R, Han C, Hou J, Jiang M.   +8 more
europepmc   +1 more source

Multimodal Quad‐Finger Soft Robotic Hand With Dual‐Chamber Origami Actuator for Large‐Workspace Manipulation

Advanced Intelligent Systems, EarlyView.
A multimodal quad‐finger soft robotic hand (QDO hand) uses dual‐chamber straight–curved origami prismatic (SCOP) origami actuators. By coordinating positive and negative pressurization in the two chambers, each finger produces axial extension, contraction and bidirectional bending.
Qinlin Tan, Sipeng Zhou, Yanlin Chen, Tianqi Yang, Xiangyu Chu, Sicong Liu, Raymond Kai‐Yu Tong   +6 more
wiley   +1 more source

Striking olfactory receptor gene repertoire expansion in Senegalese sole (<i>Solea senegalensis</i>). [PDF]

iScience
Torres-Sabino D, Carballeda M, Aramburu O, Sánchez-Quinteiro P, Robledo D, Bouza C, Martínez P.   +6 more
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

TCR repertoire shaping of naïve T cell subsets in human ontogeny. [PDF]

Front Immunol
Myshkin MY, Leyn SA, Egorov ES, Shelyakin PV, Staroverov DB, Shagina IA, Kan NE, Lupyr KR, Barsova EV, Dzyubinskaya EV, Ventura-Carmenate Y, Tyutyunnik VL, Rebrikov DV, Chudakov DM, Britanova OV.   +14 more
europepmc   +1 more source