Advanced ScienceGenomic loci and genome‐independent DNA exhibit heterogeneous dynamics related to physiological function. Live‐cell imaging of non‐repetitive sequences is essential but limited by low signal‐to‐noise ratio (SNR), restricting accurate identification and ...
Lei Feng +9 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Parity among the randomly amplified polymorphic DNA method, multilocus enzyme electrophoresis, and Southern blot hybridization with the moderately repetitive DNA probe Ca3 for fingerprinting Candida albicans [PDF]
, 1997 C. Pujol +5 more
openalex +1 more source
Repetitive DNA is Functional and Encodes Parts of the Non-Coding RNA Repertoire. [PDF]
Adv Genet (Hoboken), 2022 Shapiro JA.
europepmc +1 more source
METODE SIDIK JARI DNA DENGAN REP-PCR [PDF]
, 2009 Analisis repetitive genomic sequences- Polymerase Chain Reaction (rep-PCR) adalah metode pelipatgandaan DNA menggunakan primer oligonukleotida untuk mengamplifikasi urutan nukleotida repetitif dalam genom mikrobia.
Yuyun, Farida
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Short Interrupted Repeat Cassette (SIRC)-Novel Type of Repetitive DNA Element Found in Arabidopsis thaliana. [PDF]
Int J Mol Sci, 2023 Gorbenko IV +4 more
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Transposable Elements as a Source of Novel Repetitive DNA in the Eukaryote Genome. [PDF]
Cells, 2022 Zattera ML, Bruschi DP.
europepmc +1 more source
Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line [PDF]
, 1984 We demonstrated that a subclone of an Abelson murine leukemia virus-transformed B-lymphoid cell line switched from mu to gamma 2b expression in vitro, by the classical recombination-deletion mechanism.
Alt, Frederick W. +5 more
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