Results 1 to 10 of about 3,335,276 (377)

New Approaches to Multi-Parametric HIV-1 Genetics Using Multiple Displacement Amplification: Determining the What, How, and Where of the HIV-1 Reservoir

Viruses, 2021
Development of potential HIV-1 curative interventions requires accurate characterization of the proviral reservoir, defined as host-integrated viral DNA genomes that drive rebound of viremia upon halting ART (antiretroviral therapy).
Sean C. Patro, Aurelie Niyongabo, Frank Maldarelli, Mary F. Kearney   +3 more
doaj   +1 more source

The Role of Capsid in HIV-1 Nuclear Entry

Viruses, 2021
HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration.
Anabel Guedán, Eve R. Caroe, Genevieve C. R. Barr, Kate N. Bishop   +3 more
doaj   +1 more source

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Nature, 2021
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B ...
P. Mlcochova, S. Kemp, M. S. Dhar, G. Papa, B. Meng, I. Ferreira, R. Datir, D. Collier, Anna Albecka, S. Singh, R. Pandey, Jonathan C. Brown, Jie Zhou, Niluka Goonawardane, Swapnil Mishra, C. Whittaker, T. Mellan, Robin Marwal, Meena Datta, S. Sengupta, Kalaiarasan Ponnusamy, V. Radhakrishnan, A. Abdullahi, O. Charles, P. Chattopadhyay, P. Devi, D. Caputo, T. Peacock, Dr Chand Wattal, N. Goel, A. Satwik, Raju Vaishya, Meenakshi Agarwal, Antranik Mavousian, J. Lee, J. Bassi, Chiara Silacci-Fegni, C. Saliba, D. Pinto, T. Irie, I. Yoshida, W. Hamilton, Kei Sato, S. Bhatt, S. Flaxman, L. James, D. Corti, L. Piccoli, W. Barclay, P. Rakshit, Anurag Agrawal, Ravindra K. Gupta   +51 more
semanticscholar   +1 more source

Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection

Viruses, 2021
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target proviral populations in cells that persist for prolonged periods and that can undergo clonal expansion.
Chuen-Yen Lau, Matthew A. Adan, Frank Maldarelli   +2 more
doaj   +1 more source

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Journal of Medical Virology, 2020
The recent emergence of a novel coronavirus (2019‐nCoV), which is causing an outbreak of unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of the risk of CoVs posed to public health.
Yu Chen, Qianyun Liu, D. Guo
semanticscholar   +1 more source

Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]

, 2020
DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan, Keszthelyi, Andrea, Minchell, Nicola Elizabeth   +2 more
core   +1 more source

Coronavirus biology and replication: implications for SARS-CoV-2

Nature Reviews Microbiology, 2020
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the human population.
P. V’kovski, A. Kratzel, Silvio Steiner, H. Stalder, V. Thiel   +4 more
semanticscholar   +1 more source

Investigating Variation in Replicability: A “Many Labs” Replication Project

, 2022
Although replication is a central tenet of science, direct replications are rare in psychology. This research tested variation in the replicability of thirteen classic and contemporary effects across 36 independent samples totaling 6,344 participants. In
R. A. Klein, Kate A. Ratliff, M. Vianello, Reginald B. Adams, Š. Bahník, M. Bernstein, K. Bocian, M. Brandt, B. Brooks, C. Brumbaugh, Z. Cemalcılar, Jesse J. Chandler, Winnee Cheong, W. E. Davis, T. Devos, M. Eisner, Natalia Frankowska, D. Furrow, E. Galliani, F. Hasselman, Joshua A. Hicks, James F. Hovermale, S. J. Hunt, Jeffrey R. Huntsinger, H. Ijzerman, Melissa-Sue John, Jennifer A. Joy-Gaba, H. Kappes, Lacy E. Krueger, Jaime L. Kurtz, C. Levitan, Robyn K. Mallett, Wendy L. Morris, A. J. Nelson, J. Nier, Grant Packard, Ronaldo Pilati, Abraham M. Rutchick, Kathleen Schmidt, Jeanine L. M. Skorinko, Robert W. Smith, Troy G Steiner, Justin Storbeck, Lyn M. Van Swol, Donna M. Thompson, A. V. Veer, L. Vaughn, M. Vranka, A. Wichman, Julie A. Woodzicka, Brian A. Nosek   +50 more
semanticscholar   +1 more source

Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CL^pro Inhibitors

Viruses, 2021
The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases.
Jonathan M. O. Rawson, Alice Duchon, Olga A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu   +4 more
doaj   +1 more source

MTBP phosphorylation controls DNA replication origin firing

Scientific Reports, 2021
Faithful genome duplication requires regulation of origin firing to determine loci, timing and efficiency of replisome generation. Established kinase targets for eukaryotic origin firing regulation are the Mcm2-7 helicase, Sld3/Treslin/TICRR and Sld2 ...
Pedro Ferreira, Verena Höfer, Nora Kronshage, Anika Marko, Karl-Uwe Reusswig, Bilal Tetik, Christoph Dießel, Kerstin Köhler, Nikolai Tschernoster, Janine Altmüller, Nina Schulze, Boris Pfander, Dominik Boos   +12 more
doaj   +1 more source