Results 1 to 10 of about 2,152,940 (333)
Viruses, 2021 Development of potential HIV-1 curative interventions requires accurate characterization of the proviral reservoir, defined as host-integrated viral DNA genomes that drive rebound of viremia upon halting ART (antiretroviral therapy).
Sean C. Patro +3 more
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The Role of Capsid in HIV-1 Nuclear Entry
Viruses, 2021 HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration.
Anabel Guedán +3 more
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Viruses, 2021 Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target proviral populations in cells that persist for prolonged periods and that can undergo clonal expansion.
Chuen-Yen Lau +2 more
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Viruses, 2021 The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases.
Jonathan M. O. Rawson +4 more
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MTBP phosphorylation controls DNA replication origin firing
Scientific Reports, 2021 Faithful genome duplication requires regulation of origin firing to determine loci, timing and efficiency of replisome generation. Established kinase targets for eukaryotic origin firing regulation are the Mcm2-7 helicase, Sld3/Treslin/TICRR and Sld2 ...
Pedro Ferreira +12 more
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mBio, 2021 Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon +9 more
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Replication and trustworthiness [PDF]
Accountability in Research, 2021 This paper explores various relations that exist between replication and trustworthiness. After defining "trust", "trustworthiness", "replicability", "replication study", and "successful replication", we consider, respectively, how trustworthiness relates to each of the three main kinds of replication: reproductions, direct replications, and conceptual
Rik Peels, Lex Bouter
openaire +4 more sources
Kinds of Replication: Examining the Meanings of “Conceptual Replication” and “Direct Replication” [PDF]
Perspectives on Psychological Science, 2022 Although psychology’s recent crisis has been attributed to various scientific practices, it has come to be called a “replication crisis,” prompting extensive appraisals of this putatively crucial scientific practice. These have yielded disagreements over what kind of replication is to be preferred and what phenomena are being explored, yet the ...
Maarten Derksen, Jill Morawski
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Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication
mBio, 2022 Frequent recombination is a hallmark of retrovirus replication. In rare cases, recombination occurs between distantly related retroviruses, generating novel viruses that may significantly impact viral evolution and public health.
Jonathan M. O. Rawson +10 more
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The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects. [PDF]
, 2018 Genome instability is associated with tumorigenesis. Here, we identify a role for the histone Htz1, which is deposited by the Swr1 chromatin-remodeling complex (SWR-C), in preventing genome instability in the absence of the replication fork/replication ...
Branzei, Dana +5 more
core +2 more sources