Results 101 to 110 of about 1,350,402 (318)

Viral Replication Complexes: Structures, Functions, Applications and Inhibitors

, 2016
Viruses are obligate intracellular parasites that need to co-opt a living cell’s machinery for replication. At the heart of the viral replication machinery are the nucleic acid polymerases, which are responsible for efficiently copying the viral genome ...

core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

MangoTeam/replication-package:

, 2021
Replication package for FSE '21, Synthesis of Web Layouts from ...
Dylan Lukes, John Sarracino
core   +1 more source

HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV

mBio
HIV-1 unspliced RNA serves two distinct functions during viral replication: it is packaged into particles as the viral genome, and it is translated to generate Gag/Gag-Pol polyproteins required for virus assembly. Recent studies have demonstrated that in
Saiful Islam, Frank Maldarelli, Olga A. Nikolaitchik, Zetao Cheng, Robert Gorelick, Maria A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

DNA replication licensing in somatic and germ cells [PDF]

, 2004
The DNA replication (or origin) licensing system ensures precise duplication of the genome in each cell cycle and is a powerful regulator of cell proliferation in metazoa.
Williams, C, Jung, Hyo-Il, Obermann, EC, Ellen C. Obermann, Kai Stoeber, Loddo, Marco, Kathryn Leigh Eward, Marco Loddo, Shreeram, S, Williams, GH, Obermann, Ellen C, Hyo-Il Jung, Williams, Craig, J. Julian Blow, Gareth H. Williams, Eward, Kathryn Leigh, Fanshawe, Thomas, Jung, HI, Shreeram, S., Prevost, Toby; id_orcid, Blow, J. Julian; id_orcid, A. Toby Prevost, Loddo, M, Williams, Gareth H., Thomas Fanshawe, Fanshawe, T, Obermann, Ellen C., Eward, KL, Williams, Gareth H, Jung, H-I, S. Shreeram, Blow, J Julian, Prevost, A. Toby, Stoeber, K, Stoeber, Kai, Blow, J. Julian, Prevost, AT, Blow, JJ, Craig Williams   +38 more
core   +1 more source

Proteomic data on the nuclear interactome of human MCM9

Data in Brief, 2016
We present data relating to the interactome of MCM9 from the nuclei of human cells. MCM9 belongs to the AAA+ superfamily, and contains an MCM domain and motifs that may confer DNA helicase activity.
James R.A. Hutchins, Sabine Traver, Philippe Coulombe, Isabelle Peiffer, Magali Kitzmann, Daniel Latreille, Marcel Méchali   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

replication-files: First release

, 2015
Replication files for my published and forthcoming ...
Danilo Freire
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source