Results 11 to 20 of about 1,185,258 (299)
Replication and trustworthiness [PDF]
Accountability in Research, 2021 This paper explores various relations that exist between replication and trustworthiness. After defining "trust", "trustworthiness", "replicability", "replication study", and "successful replication", we consider, respectively, how trustworthiness relates to each of the three main kinds of replication: reproductions, direct replications, and conceptual
Rik Peels, Lex Bouter
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Kinds of Replication: Examining the Meanings of “Conceptual Replication” and “Direct Replication” [PDF]
Perspectives on Psychological Science, 2022 Although psychology’s recent crisis has been attributed to various scientific practices, it has come to be called a “replication crisis,” prompting extensive appraisals of this putatively crucial scientific practice. These have yielded disagreements over what kind of replication is to be preferred and what phenomena are being explored, yet the ...
Maarten Derksen, Jill Morawski
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Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins
mBio, 2021 Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response.
Cheng Man Lun +4 more
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Replicability and replication in the humanities [PDF]
Research Integrity and Peer Review, 2019 A large number of scientists and several news platforms have, over the last few years, been speaking of a replication crisis in various academic disciplines, especially the biomedical and social sciences. This paper answers the novel question of whether we should also pursue replication in the humanities.
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Distributional Replication [PDF]
Entropy, 2021 A function which transforms a continuous random variable such that it has a specified distribution is called a replicating function. We suppose that functions may be assigned a price, and study an optimization problem in which the cheapest approximation to a replicating function is sought.
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Replicating replicability modeling of psychology papers [PDF]
Proceedings of the National Academy of Sciences, 2023 Youyou et al. (1) estimated the replicability of more than 14,000 psychology papers using a machine learning model, trained on main texts of 388 replicated studies. The authors identified mean replicability scores of psychological subfields. They also verified the causality of the model predictions; correlations between model predictions and study ...
Aske Mottelson, Dimosthenis Kontogiorgos
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The role of integration and clonal expansion in HIV infection: live long and prosper
Retrovirology, 2018 Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that ...
Elizabeth M. Anderson, Frank Maldarelli
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IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag
mBio, 2020 Interferon-induced transmembrane (IFITM) proteins are encoded by many vertebrate species and exhibit antiviral activities against a wide range of viruses.
Yadvinder S. Ahi +6 more
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Nature Communications, 2022 Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how
Almutasem Saleh +9 more
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Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
eLife, 2021 The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
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