Results 11 to 20 of about 2,152,940 (333)

The mechanism of replication stalling and recovery within repetitive DNA

Nature Communications, 2022
DNA replication of repetitive sequences was recreated in a test tube using purified components. DNA alone was sufficient to induce stalling. Both stalling and recovery were dictated by the capacity of DNA to fold into unusual secondary structures.
Corella S. Casas-Delucchi, Manuel Daza-Martin, Sophie L. Williams, Gideon Coster   +3 more
doaj   +1 more source

Proficient replication of the yeast genome by a viral DNA polymerase [PDF]

, 2016
DNA replication in eukaryotic cells requires minimally three B-family DNA polymerases: Pol α, Pol δ, and Pol ϵ. Pol δ replicates and matures Okazaki fragments on the lagging strand of the replication fork.
Burgers, Peter M, Stith, Carrie M, Stodola, Joseph L   +2 more
core   +2 more sources

Distributional Replication [PDF]

Entropy, 2021
A function which transforms a continuous random variable such that it has a specified distribution is called a replicating function. We suppose that functions may be assigned a price, and study an optimization problem in which the cheapest approximation to a replicating function is sought.
openaire   +5 more sources

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements [PDF]

, 2015
Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability.
A Janssen, A Letessier, AT Watson, AT Watson, BJ Brewer, C Lukas, D Branzei, E Ampatzidou, E Tsang, EK Schwartz, HD Lindsay, I Miyabe, J Bartkova, J Matos, JA Harrigan, JM Murray, K Mizuno, K Mizuno, K Tanaka, KL Chan, KL Chan, LJ Gaskell, MN Boddy, NC Walworth, O Limbo, P Huertas, PM Dehe, RA Burrell, S Lambert, S Lambert, S Minocherhomji, S Sarbajna, S Ying, SC Ip, SG Durkin, SM Mirkin, T Caspari, V Naim, VG Gorgoulis, X Li   +39 more
core   +1 more source

Replicating replicability modeling of psychology papers [PDF]

Proceedings of the National Academy of Sciences, 2023
Youyou et al. (1) estimated the replicability of more than 14,000 psychology papers using a machine learning model, trained on main texts of 388 replicated studies. The authors identified mean replicability scores of psychological subfields. They also verified the causality of the model predictions; correlations between model predictions and study ...
Aske Mottelson, Dimosthenis Kontogiorgos
openaire   +3 more sources

USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator [PDF]

, 2012
The nuclear genomes of vertebrates show a highly organized program of DNA replication where GC-rich isochores are replicated early in S-phase, while AT-rich isochores are late replicating.
Boggetto, N., Cadoret, J-C., Chilaka, S., Hassan-Zadeh, V., Ma, M., Prioleau, M-N., West, A. G.   +6 more
core   +8 more sources

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

eLife, 2015
We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes.
Roxana E Georgescu, Grant D Schauer, Nina Y Yao, Lance D Langston, Olga Yurieva, Dan Zhang, Jeff Finkelstein, Mike E O'Donnell   +7 more
doaj   +1 more source

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

eLife, 2021
The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
doaj   +1 more source

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]

, 2010
In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Alexander M. Thomson, Berezney, Blasina, Blow, Blow, Boutros, Brown, Chong, Cohen, Dimitrova, Dimitrova, Dimitrova, Dimitrova, Donaldson, Eshaghi, Farkash-Amar, Feijoo, Ferenbach, Frouin, Ge, Gilbert, Goldberg, Goren, Hartley, Hayashi, Heichinger, Hiratani, Howe, J. Julian Blow, Jackson, Jeon, Karlsson-Rosenthal, Kitamura, Krasinska, Labit, Luciani, MacAlpine, Masumoto, Mickle, Moore, Nishitani, O'Keefe, Okuno, Peter J. Gillespie, Platani, Raghuraman, Raghuraman, Rempel, Santocanale, Sarkaria, Schübeler, Shechter, Shirahige, Strausfeld, Strausfeld, Swedlow, Tanaka, Vernon, White, Woodfine, Woodfine, Woodward, Wu, Zegerman, Zink   +64 more
core   +4 more sources

Replicability and replication in the humanities [PDF]

Research Integrity and Peer Review, 2019
A large number of scientists and several news platforms have, over the last few years, been speaking of a replication crisis in various academic disciplines, especially the biomedical and social sciences. This paper answers the novel question of whether we should also pursue replication in the humanities.
openaire   +5 more sources