Results 21 to 30 of about 1,158,325 (299)

Transcription Start Site Heterogeneity and Preferential Packaging of Specific Full-Length RNA Species Are Conserved Features of Primate Lentiviruses

Microbiology Spectrum, 2022
HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL molecular clones,
Jonathan M. O. Rawson, Olga A. Nikolaitchik, Saurabh Shakya, Brandon F. Keele, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

Replication, Replication [PDF]

PS: Political Science & Politics, 1995
Political science is a community enterprise; the community of empirical political scientists needs access to the body of data necessary to replicate existing studies to understand, evaluate, and especially build on this work. Unfortunately, the norms we have in place now do not encourage, or in some cases even permit, this aim.
openaire   +2 more sources

Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

mBio, 2021
Although combination antiretroviral (ARV) therapy is highly effective in controlling the progression of HIV disease, drug resistance can be a major obstacle. Recent findings suggest that resistance can develop without ARV target gene mutations.
Yuta Hikichi, Rachel Van Duyne, Phuong Pham, Jennifer L. Groebner, Ann Wiegand, John W. Mellors, Mary F. Kearney, Eric O. Freed   +7 more
doaj   +1 more source

The Replication Recipe: What Makes for a Convincing Replication? [PDF]

SSRN Electronic Journal, 2013
Psychological scientists have recently started to reconsider the importance of close replications in building a cumulative knowledge base; however, there is no consensus about what constitutes a convincing close replication study. To facilitate convincing close replication attempts we have developed a Replication Recipe, outlining standard criteria for
Brandt, M, IJzerman, H, Dijksterhuis, A, Farach, F, Geller, J, Giner Sorolla, R, Grange, J, PERUGINI, MARCO, Spies, J, van 't Veer, A.   +9 more
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Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution

mBio, 2020
HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen, Chijioke Umunnakwe, David Q. Sun, Olga A. Nikolaitchik, Vinay K. Pathak, Ben Berkhout, Atze T. Das, Wei-Shau Hu   +7 more
doaj   +1 more source

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells

Retrovirology, 2023
Background SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these ...
Ming-Han C. Tsai, Sarah J. Caswell, Elizabeth R. Morris, Melanie C. Mann, Simon Pennell, Geoff Kelly, Harriet C. T. Groom, Ian A. Taylor, Kate N. Bishop   +8 more
doaj   +1 more source

Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2

Cell Reports, 2016
Temporal separation of DNA replication initiation into licensing and firing phases ensures the precise duplication of the genome during each cell cycle.
Karl-Uwe Reusswig, Fabian Zimmermann, Lorenzo Galanti, Boris Pfander   +3 more
doaj   +1 more source

Does the Cytoplasmic Tail Matter? Mechanism of Viral Envelope Glycoprotein Targeting by Membrane-Associated-RING-CH (MARCH) Proteins

Proceedings, 2020
The MARCH family of RING-finger E3 ubiquitin ligases comprise 11 members that have been reported to play a variety of roles in the downregulation of cell-surface proteins involved in adaptive immunity.
Cheng man Lun, Abdul A. Waheed, Eric O. Freed   +2 more
doaj   +1 more source

HIV-1 Capsid Rapidly Induces Long-Lived CPSF6 Puncta in Non-Dividing Cells, but Similar Puncta Already Exist in Uninfected T-Cells

Viruses
The HIV-1 capsid (CA) protein forms the outer shell of the viral core that is released into the cytoplasm upon infection. CA binds various cellular proteins, including CPSF6, that direct HIV-1 integration into speckle-associated domains in host chromatin.
Anabel Guedán, Megan Burley, Eve R. Caroe, Kate N. Bishop   +3 more
doaj   +1 more source

Molecular replication [PDF]

Nature, 1985
The replication of DNA is the process by means of which genetic information is passed from one generation to the next in all living organisms. It is widely believed that a similar process must have become important early in the development of life on the Earth, either before or at the same time as the evolution of protein synthesis.
openaire   +2 more sources