Results 21 to 30 of about 2,152,940 (333)

IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag

mBio, 2020
Interferon-induced transmembrane (IFITM) proteins are encoded by many vertebrate species and exhibit antiviral activities against a wide range of viruses.
Yadvinder S. Ahi, Diborah Yimer, Guoli Shi, Saliha Majdoul, Kazi Rahman, Alan Rein, Alex A. Compton   +6 more
doaj   +1 more source

Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments [PDF]

, 2009
Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV ...
Ahmed, Bertrand, Besse, Boehmer, Boisvert, Cheng, Copenhaver, D. A. Matthews, de Jong, Everett, Grummt, Hiscox, Kuhn, Lawrence, Liu, Lymberopoulos, Mears, Meraner, N. D. Stow, Pederson, Puvion-Dutilleul, Roller, Stow, Strang, Taylor, V. C. Evans   +25 more
core   +2 more sources

The role of integration and clonal expansion in HIV infection: live long and prosper

Retrovirology, 2018
Integration of viral DNA into the host genome is a central event in the replication cycle and the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are rapidly eliminated in vivo, HIV also infects long-lived cells that ...
Elizabeth M. Anderson, Frank Maldarelli
doaj   +1 more source

Escalation of error catastrophe for enzymatic self-replicators [PDF]

, 2007
It is a long-standing question in origin-of-life research whether the information content of replicating molecules can be maintained in the presence of replication errors.
B. Obermayer, E. Frey, Jain K. Krug J., Schuster P., Stadler P., Tee G.   +5 more
core   +2 more sources

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer

Nature Communications, 2022
Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how
Almutasem Saleh, Yasunori Noguchi, Ricardo Aramayo, Marina E. Ivanova, Kathryn M. Stevens, Alex Montoya, S. Sunidhi, Nicolas Lopez Carranza, Marcin J. Skwark, Christian Speck   +9 more
doaj   +1 more source

Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins

mBio, 2021
Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response.
Cheng Man Lun, Abdul A. Waheed, Ahlam Majadly, Nicole Powell, Eric O. Freed   +4 more
doaj   +1 more source

Reversal of terminal differentiation and control of DNA replication [PDF]

, 1993
DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina, Leonhardt, Heinrich, Nadal-Ginard, Bernardo   +2 more
core   +1 more source

Restriction of Influenza A Virus by SERINC5

mBio, 2022
Serine incorporator 5 (Ser5), a transmembrane protein, has recently been identified as a host antiviral factor against human immunodeficiency virus (HIV)-1 and gammaretroviruses like murine leukemia viruses (MLVs). It is counteracted by HIV-1 Nef and MLV
Kin Kui Lai, James B. Munro, Guoli Shi, Saliha Majdoul, Alex A. Compton, Alan Rein   +5 more
doaj   +1 more source

Genetic and physical mapping of DNA replication origins in Haloferax volcanii [PDF]

, 2007
The halophilic archaeon Haloferax volcanii has a multireplicon genome, consisting of a main chromosome, three secondary chromosomes, and a plasmid. Genes for the initiator protein Cdc6/Orc1, which are commonly located adjacent to archaeal origins of DNA ...
Allers, T, Eisen, JA, Hartman, AL, Hawkins, M, Myllykallio, H, Norais, C   +5 more
core   +6 more sources

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories [PDF]

, 2010
Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase. However, only ∼10% of licensed origins are normally used in S phase, with the others remaining dormant.
Anglana, Arias, Bartek, Berezney, Blow, Blow, Blow, Bourke, Boutros, Branzei, Chung, Cseresnyes, Dijkwel, Dimitrova, Doksani, Ge, Gilbert, Gillespie, Hiratani, Ibarra, J. Julian Blow, Jackson, Kitamura, Krasinska, Kunnev, Lambert, Leonhardt, Lopes, Maya-Mendoza, Ockey, Pruitt, Sadoni, Santocanale, Santocanale, Shima, Shirahige, Sporbert, Taylor, Tercero, Thomson, Timofeev, Tuduri, Woodward, Xin Quan Ge, Zachos   +44 more
core   +3 more sources