Results 1 to 10 of about 1,145,720 (307)

HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. [PDF]

, 2017
Antiviral innate host defenses against acute viral infections include suppression of host protein synthesis to restrict viral protein production.
Clarissa Santos Rocha, Erica A. Mendes, George R. Thompson, Guochun Jiang, Joseph K. Wong, Lauren A. Hirao, Ruth Ruprecht, Satya Dandekar, Vinayaka R. Prasad, Yuyang Tang   +9 more
core   +2 more sources

Capsid Proteins are Necessary for Replication of a Parvovirus [PDF]

Journal of Virology, 2020
AbstractDespite tight genetic compression, viral genomes are often organized in functional gene clusters, a modular structure that might favor their evolvability. This has greatly facilitated biotechnological developments, such as the recombinant Adeno-Associated Virus (AAV) systems for gene therapy.
Labadie, Thomas, Garcia, Deborah, Mutuel, Doriane, Ogliastro, Mylène, Cambray, Guillaume   +4 more
openaire   +4 more sources

Eukaryotic RNA binding protein hnRNPH1 suppresses influenza A virus replication through interaction with virus NS1 protein

Emerging Microbes and Infections
The NS1 protein of influenza A virus (IAV) is a multi-functional protein which can antagonize host immune system and facilitate viral replication by interacting with host factors.
Jinyu Wang, Yang Zhang, Lishan Sun, Zihan Wang, Cui Hao, Wei Wang   +5 more
doaj   +1 more source

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

Emerging Microbes and Infections, 2017
The M gene segment of influenza A virus has been shown to be a contributing factor to the high growth phenotype. However, it remains largely unknown why matrix protein 1 (M1), the major structural protein encoded by M gene, exhibits pH-dependent ...
Meng-Jung Chiang, Faik N Musayev, Martina Kosikova, Zhengshi Lin, Yamei Gao, Philip D Mosier, Bashayer Althufairi, Zhiping Ye, Qibing Zhou, Umesh R Desai, Hang Xie, Martin K Safo   +11 more
doaj   +1 more source

The consequences of replicating in the wrong orientation: Bacterial chromosome duplication without an active replication origin [PDF]

, 2015
Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli the DnaA initiator protein regulates the assembly of replication forks at oriC.
Dimude, JU, Foster, HA, Khan, A, Midgley-Smith, SL, Retkute, R, Rudolph, CJ, Saunders, NJ, Stockum, A, Upton, AL   +8 more
core   +1 more source

Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex [PDF]

, 1998
The Xenopus origin recognition complex is essential for chromosomal DNA replication in cell-free extracts. We have immunopurified the Xenopus origin recognition complex with anti-Xorc2 antibodies and analyzed its composition and properties.
Carpenter, Phillip B., Dunphy, William G.   +1 more
core   +1 more source

Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]

, 2013
Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M, Liu, Jia, McFadden, Grant, Rahman, Masmudur M, Rothenburg, Stefan   +4 more
core   +1 more source

Regulation of DNA Replication after Heat Shock by Replication Protein A-Nucleolin Interactions [PDF]

Journal of Biological Chemistry, 2001
Heat shock inhibits replicative DNA synthesis, but the underlying mechanism remains unknown. We investigated mechanistic aspects of this regulation in melanoma cells using a simian virus 40 (SV40)-based in vitro DNA replication assay. Heat shock (44 degrees C) caused a monotonic inhibition of cellular DNA replication following exposures for 5-90 min ...
Wang, Yizheng, Guan, Jun, Wang, Hongyan, Wang, Ya, Leeper, Dennis, Iliakis, George   +5 more
openaire   +2 more sources

Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination Regulation

Cell Reports, 2017
Srs2 is a super-family 1 helicase that promotes genome stability by dismantling toxic DNA recombination intermediates. However, the mechanisms by which Srs2 remodels or resolves recombination intermediates remain poorly understood.
Luisina De Tullio, Kyle Kaniecki, Youngho Kwon, J. Brooks Crickard, Patrick Sung, Eric C. Greene   +5 more
doaj   +1 more source

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Nature Communications, 2020
DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication forks.
Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida   +6 more
doaj   +1 more source