Results 11 to 20 of about 1,145,720 (307)

Human hnRNPA1 reorganizes telomere-bound replication protein A. [PDF]

Nucleic Acids Res, 2023
AbstractHuman replication protein A (RPA) is a heterotrimeric ssDNA binding protein responsible for many aspects of cellular DNA metabolism. Dynamic interactions of the four RPA DNA binding domains (DBDs) with DNA control replacement of RPA by downstream proteins in various cellular metabolic pathways. RPA plays several important functions at telomeres
Granger SL, Sharma R, Kaushik V, Razzaghi M, Honda M, Gaur P, Bhat DS, Labenz SM, Heinen JE, Williams BA, Tabei SMA, Wlodarski MW, Antony E, Spies M.   +13 more
europepmc   +5 more sources

DNA-binding mechanism and evolution of replication protein A [PDF]

Nature Communications, 2023
Replication Protein A (RPA) is a heterotrimeric single stranded DNA-binding protein with essential roles in DNA replication, recombination and repair. Little is known about the structure of RPA in Archaea, the third domain of life.
Clément Madru, Markel Martínez-Carranza, Sébastien Laurent, Alessandra C. Alberti, Maelenn Chevreuil, Bertrand Raynal, Ahmed Haouz, Rémy A. Le Meur, Marc Delarue, Ghislaine Henneke, Didier Flament, Mart Krupovic, Pierre Legrand, Ludovic Sauguet   +13 more
doaj   +2 more sources

In Vivo Targeting Replication Protein A for Cancer Therapy [PDF]

Frontiers in Oncology, 2022
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for ...
Pamela S. VanderVere-Carozza, Navnath S. Gavande, Navnath S. Gavande, Shadia I. Jalal, Karen E. Pollok, Elmira Ekinci, Joshua Heyza, Steve M. Patrick, Andi Masters, John J. Turchi, John J. Turchi, Katherine S. Pawelczak   +11 more
doaj   +2 more sources

Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond. [PDF]

NAR Cancer, 2020
AbstractSingle-stranded DNA (ssDNA) forms continuously during DNA replication and is an important intermediate during recombination-mediated repair of damaged DNA. Replication protein A (RPA) is the major eukaryotic ssDNA-binding protein. As such, RPA protects the transiently formed ssDNA from nucleolytic degradation and serves as a physical platform ...
Dueva R, Iliakis G.
europepmc   +4 more sources

ssDNA diffuses along replication protein A via a reptation mechanism. [PDF]

Nucleic Acids Res, 2020
Abstract Replication protein A (RPA) plays a critical role in all eukaryotic DNA processing involving single-stranded DNA (ssDNA). Contrary to the notion that RPA provides solely inert protection to transiently formed ssDNA, the RPA–ssDNA complex acts as a dynamic DNA processing unit.
Mishra G, Bigman LS, Levy Y.
europepmc   +4 more sources

Secretory Carrier Membrane Protein 3 Interacts with 3A Viral Protein of Enterovirus and Participates in Viral Replication

Microbiology Spectrum, 2021
Picornaviruses are a diverse and major cause of human disease, and their genomes replicate with intracellular membranes. The functionality of these replication organelles depends on the activities of both viral nonstructural proteins and co-opted host ...
Jia-Ying Lu, Gary Brewer, Mei-Ling Li, Kai-Zhe Lin, Chien-Chih Huang, Li-Chen Yen, Jing-Yi Lin   +6 more
doaj   +1 more source

Human Replication Protein A [PDF]

Journal of Biological Chemistry, 2003
Although the mechanical aspects of the single-stranded DNA (ssDNA) binding activity of human replication protein A (RPA) have been extensively studied, only limited information is available about its interaction with other physiologically relevant DNA structures.
Pestryakov, Pavel E., Weisshart, Klaus, Schlott, Bernhard, Khodyreva, Svetlana N., Kremmer, Elisabeth, Grosse, Frank, Lavrik, Olga I., Nasheuer, Heinz-Peter   +7 more
openaire   +1 more source

Interaction and assembly of the DNA replication core proteins of Kaposi’s sarcoma-associated herpesvirus

Microbiology Spectrum, 2023
Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes six highly conserved core replication proteins essential for the viral lytic DNA synthesis, including ORF6 (single-stranded DNA-binding protein), ORF9 (DNA polymerase), ORF40/41 (primase-associated ...
Lee-Wen Chen, Shie-Shan Wang, Li-Yu Chen, Hsiao-Yun Huang, Si-min He, Chien-Hui Hung, Chun-Liang Lin, Pey-Jium Chang   +7 more
doaj   +1 more source

Diphenylpyrazoles as Replication Protein A Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2014
Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RPA70N).
Alex G, Waterson, J Phillip, Kennedy, James D, Patrone, Nicholas F, Pelz, Michael D, Feldkamp, Andreas O, Frank, Bhavatarini, Vangamudi, Elaine M, Souza-Fagundes, Olivia W, Rossanese, Walter J, Chazin, Stephen W, Fesik   +10 more
openaire   +2 more sources

Cellular PSMB4 Protein Suppresses Influenza A Virus Replication through Targeting NS1 Protein

Viruses, 2022
The nonstructural protein 1 (NS1) of influenza A virus (IAV) possesses multiple functions, such as the inhibition of the host antiviral immune responses, to facilitate viral infection. To search for cellular proteins interacting with the IAV NS1 protein,
Chee-Hing Yang, Che-Fang Hsu, Xiang-Qing Lai, Yu-Ru Chan, Hui-Chun Li, Shih-Yen Lo   +5 more
doaj   +1 more source