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Virus Research, 2022 Coronavirus subverts the host cell cycle to create a favorable cellular environment that enhances viral replication in host cells. Previous studies have revealed that nucleocapsid (N) protein of the coronavirus porcine epidemic diarrhea virus (PEDV ...
Qinghe Zhu +10 more
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Chromatin Association of Replication Protein A [PDF]
Journal of Biological Chemistry, 1998 Replication protein A (RPA) is the major single strand-specific DNA-binding protein in eukaryotic cells. We have investigated the distribution of RPA in nuclei of proliferating HeLa cells and found that only one-third of the detectable RPA appeared to be bound to DNA in chromatin, whereas the remainder was free in the nucleosol.
K, Treuner, C, Eckerich, R, Knippers
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Drosophila RecQ4 Is Directly Involved in Both DNA Replication and the Response to UV Damage in S2 Cells. [PDF]
, 2012 The RecQ4 protein shows homology to both the S.cerevisiae DNA replication protein Sld2 and the DNA repair related RecQ helicases. Experimental data also suggest replication and repair functions for RecQ4, but the precise details of its involvement remain
Cotterill, S +6 more
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The Fis protein has a stimulating role in initiation of replication in Escherichia coli in vivo. [PDF]
PLoS ONE, 2013 The Fis protein is a nucleoid associated protein that has previously been reported to act negatively in initiation of replication in Escherichia coli.
Ingvild Flåtten, Kirsten Skarstad
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SUMOylation Is Essential for Dengue Virus Replication and Transmission in the Mosquito Aedes aegypti
Frontiers in Microbiology, 2022 Small ubiquitin-like modifier (SUMO) is a reversible post-translational protein modifier. Protein SUMOylation regulates a wide variety of cellular processes and is important for controlling virus replication.
Shih-Che Weng, Shin-Hong Shiao
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Replication Protein A (RPA) Phosphorylation Prevents RPA Association with Replication Centers [PDF]
Molecular and Cellular Biology, 2004 Mammalian replication protein A (RPA) undergoes DNA damage-dependent phosphorylation at numerous sites on the N terminus of the RPA2 subunit. To understand the functional significance of RPA phosphorylation, we expressed RPA2 variants in which the phosphorylation sites were converted to aspartate (RPA2(D)) or alanine (RPA2(A)).
Vitaly M, Vassin +2 more
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Frontiers in Cell and Developmental Biology, 2021 Flavivirus replication is intimately associated with re-organized cellular membranes. These virus-induced changes in membrane architecture form three distinct membranous “organelles” that have specific functions during the flavivirus life cycle.
Andrea Mikulasova +6 more
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DNA unwinding activity of replication protein A [PDF]
FEBS Letters, 1992 Replication protein A (RP‐A) is a heterotrimeric complex conserved in cukaryotic cells. It binds to single‐stranded DNA and is essential for initiation and elongation of DNA replication. In this communication we give evidence that this protein can unwind DNA independent of magnesium and ATP, two essential cofactors for bona fide DNA helicase activity ...
Georgaki, Anthi +3 more
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Functional Domains of a Geminivirus Replication Protein [PDF]
Journal of Biological Chemistry, 1997 Tomato golden mosaic virus, a member of the geminivirus family, has a single-stranded DNA genome that is replicated and transcribed in infected plant cells through the concerted action of viral and host factors. One viral protein, AL1, contributes to both processes by binding to a directly repeated, double-stranded DNA sequence located in the ...
B M, Orozco +3 more
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Are the SSB-Interacting Proteins RecO, RecG, PriA and the DnaB-Interacting Protein Rep Bound to Progressing Replication Forks in Escherichia coli? [PDF]
PLoS ONE, 2015 In all organisms several enzymes that are needed upon replication impediment are targeted to replication forks by interaction with a replication protein.
Esma Bentchikou +5 more
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