Results 41 to 50 of about 1,145,720 (307)

Is RecF a DNA replication protein? [PDF]

Proceedings of the National Academy of Sciences, 1997
Maintenance of genetic integrity is of foremost importance to the cell. Thus, cells are well equipped with a number of repair mechanisms for different types of DNA damage. All DNA polymerases are very sensitive to pyrimidine dimers, a major DNA lesion of UV irradiation.
openaire   +2 more sources

Human Xeroderma Pigmentosum Group A Protein Interacts with Human Replication Protein A and Inhibits DNA Replication [PDF]

Journal of Biological Chemistry, 1995
Human replication protein A (RPA; also known as human single-stranded DNA binding protein, or HSSB) is a multisubunit complex involved in both DNA replication and repair. While the role of RPA in replication has been well studied, its function in repair is less clear, although it is known to be involved in the early stages of the repair process.
S H, Lee, D K, Kim, R, Drissi
openaire   +2 more sources

Dissection of Functional Domains of the Human DNA Replication Protein Complex Replication Protein A [PDF]

Journal of Biological Chemistry, 1996
Replication protein A (RPA) is a mammalian single-stranded DNA binding factor essential for DNA replication, repair, and recombination. It is composed of three subunits of 70, 34, and 13 kDa (Rpa1, Rpa2, and Rpa3, respectively). Deletion mapping of the Rpa2 subunit identified the domain required for interaction with Rpa1 and Rpa3 which does not include
Y L, Lin, C, Chen, K F, Keshav, E, Winchester, A, Dutta   +4 more
openaire   +2 more sources

Replication protein A: directing traffic at the intersection of replication and repair [PDF]

Frontiers in Bioscience, 2010
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation.
Greg G, Oakley, Steve M, Patrick
openaire   +2 more sources

Cell-cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA viruses.

PLoS Pathogens, 2019
Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known.
Yuta Kanai, Takahiro Kawagishi, Yusuke Sakai, Ryotaro Nouda, Masayuki Shimojima, Masayuki Saijo, Yoshiharu Matsuura, Takeshi Kobayashi   +7 more
doaj   +1 more source

A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication [PDF]

, 2011
DEAD-box proteins are enzymes endowed with nucleic acid-dependent ATPase, RNA translocase and unwinding activities. The human DEAD-box protein DDX3 has been shown to play important roles in tumor proliferation and viral infections.
Garbelli, Anna, Beermann, Sandra, Di Cicco, Giulia, Dietrich, Ursula, Maga, Giovanni   +4 more
core   +1 more source

An Alternative Form of Replication Protein A Prevents Viral Replication in Vitro [PDF]

Journal of Biological Chemistry, 2009
Replication protein A (RPA), the eukaryotic single-stranded DNA-binding complex, is essential for multiple processes in cellular DNA metabolism. The "canonical" RPA is composed of three subunits (RPA1, RPA2, and RPA3); however, there is a human homolog to the RPA2 subunit, called RPA4, that can substitute for RPA2 in complex formation.
Aaron C, Mason, Stuart J, Haring, John M, Pryor, Cathy A, Staloch, Tze Fei, Gan, Marc S, Wold   +5 more
openaire   +2 more sources

Creating a novel origin of replication through modulating DNA-protein interfaces. [PDF]

PLoS ONE, 2010
While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses.
F Curtis Hewitt, R Jude Samulski
doaj   +1 more source

Direct interaction of the molecular chaperone GRP78/BiP with the Newcastle disease virus hemagglutinin-neuraminidase protein plays a vital role in viral attachment to and infection of culture cells

Frontiers in Immunology, 2023
IntroductionGlucose Regulated Proteins/Binding protein (GRP78/Bip), a representative molecular chaperone, effectively influences and actively participates in the replication processes of many viruses.
Chenxin Han, Chenxin Han, Ziwei Xie, Ziwei Xie, Yadi Lv, Yadi Lv, Dingxiang Liu, Dingxiang Liu, Dingxiang Liu, Ruiai Chen, Ruiai Chen   +10 more
doaj   +1 more source

Reversal of terminal differentiation and control of DNA replication [PDF]

, 1993
DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina, Leonhardt, Heinrich, Nadal-Ginard, Bernardo   +2 more
core   +1 more source