Results 1 to 10 of about 695,037 (266)

C-terminal substitution of HBV core proteins with those from DHBV reveals that arginine-rich 167RRRSQSPRR175 domain is critical for HBV replication. [PDF]

PLoS ONE, 2012
To investigate the contributions of carboxyl-terminal nucleic acid binding domain of HBV core (C) protein for hepatitis B virus (HBV) replication, chimeric HBV C proteins were generated by substituting varying lengths of the carboxyl-terminus of duck ...
Jaesung Jung, Hee-Young Kim, Taeyeung Kim, Bo-Hye Shin, Gil-Soon Park, Sun Park, Yong-Joon Chwae, Ho-Joon Shin, Kyongmin Kim   +8 more
doaj   +3 more sources

Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. [PDF]

PLoS Pathogens, 2013
The nonstructural protein NS5A has emerged as a new drug target in antiviral therapies for Hepatitis C Virus (HCV) infection. NS5A is critically involved in viral RNA replication that takes place at newly formed membranes within the endoplasmic reticulum
Dorothee A Vogt, Grégory Camus, Eva Herker, Brian R Webster, Chia-Lin Tsou, Warner C Greene, Tien-Sze Benedict Yen, Melanie Ott   +7 more
doaj   +3 more sources

Receptor transporter protein 4 (RTP4)-mediated repression of hepatitis C virus replication in mouse cells.

PLoS Pathogens
Hepatitis C virus (HCV) exhibits a narrow species tropism, causing robust infections only in humans and experimentally inoculated chimpanzees. While many host factors and restriction factors are known, many more likely remain unknown, which has limited ...
Michael P Schwoerer, Sebastian Carver, Aaron E Lin, Jianche Liu, Thomas R Cafiero, Keith A Berggren, Serene Dhawan, Saori Suzuki, Brigitte Heller, Celeste Rodriguez, Aoife K O'Connell, Hans P Gertje, Nicholas A Crossland, Alexander Ploss   +13 more
doaj   +3 more sources

Interaction of Nucleolin with the Fusion Protein of Avian Metapneumovirus Subgroup C Contributes to Viral Replication

Viruses, 2022
Avian metapneumovirus subgroup C (aMPV/C) is highly pathogenic to various avian species with acute respiratory tract clinicopathology and/or drops in egg production.
Dedong Wang, Lei Hou, Ning Zhu, Xiaoyu Yang, Jianwei Zhou, Yongqiu Cui, Jinshuo Guo, Xufei Feng, Jue Liu   +8 more
doaj   +1 more source

Protein Kinase C Inhibitors Reduce SARS-CoV-2 Replication in Cultured Cells

Microbiology Spectrum, 2022
Infection by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has posed a severe threat to global public health. The current study revealed that several inhibitors of protein kinases C (PKCs) possess protective activity against SARS ...
Changbai Huang, Fei Feng, Yongxia Shi, Wenhui Li, Ziqiao Wang, Yunkai Zhu, Shuai Yuan, Dandan Hu, Jun Dai, Qiqi Jiang, Rong Zhang, Chao Liu, Ping Zhang   +12 more
doaj   +1 more source

Regulation of the activity of the dual-function DnaA protein in Caulobacter crescentus. [PDF]

PLoS ONE, 2011
DnaA is a conserved essential bacterial protein that acts as the initiator of chromosomal replication as well as a master transcriptional regulator in Caulobacter crescentus.
Carmen Fernandez-Fernandez, Diego Gonzalez, Justine Collier   +2 more
doaj   +1 more source

Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection

mBio, 2023
There is a limited understanding of host defense mechanisms targeting intracellular pathogens that proliferate in a lysosome. Coxiella burnetii is a model bacterial pathogen capable of replicating in the hydrolytic and acidic environment of the lysosome.
Sandhya Ganesan, Natalie N. Alvarez, Samuel Steiner, Karen M. Fowler, Abigail K. Corona, Craig R. Roy   +5 more
doaj   +1 more source

Regulatory Role of Phospholipids in Hepatitis C Virus Replication and Protein Function

Pathogens, 2022
Positive-strand RNA viruses such as hepatitis C virus (HCV) hijack key factors of lipid metabolism of infected cells and extensively modify intracellular membranes to support the viral lifecycle.
Anna V. Bulankina, Rebecca M. Richter, Christoph Welsch   +2 more
doaj   +1 more source

AMPK inhibitor, compound C, inhibits coronavirus replication in vitro.

PLoS ONE, 2023
The coronavirus disease (COVID-19) pandemic has resulted in more than six million deaths by October 2022. Vaccines and antivirals for severe acute respiratory syndrome coronavirus 2 are now available; however, more effective antiviral drugs are required ...
Minsu Jang, Rackhyun Park, Ayane Yamamoto, Yea-In Park, Yeonjeong Park, Siyun Lee, Junsoo Park   +6 more
doaj   +1 more source

Subunit Interaction Differences Between the Replication Factor C Complexes in Arabidopsis and Rice

Frontiers in Plant Science, 2018
Replication factor C (RFC) is a multisubunit complex that opens the sliding clamp and loads it onto the DNA chain in an ATP-dependent manner and is thus critical for high-speed DNA synthesis.
Yueyue Chen, Jie Qian, Li You, Xiufeng Zhang, Jinxia Jiao, Yang Liu, Jie Zhao   +6 more
doaj   +1 more source